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BACKGROUND: Distal gastric cancer with gastric outlet obstruction (GOO) poses challenges to multimodal treatment. The optimal management strategy in patients undergoing curative-intent treatment remains unclear. This study aimed to characterize real-world management pathways and outcomes in patients with distal gastric cancer presenting with clinically significant GOO.METHODS: All consecutive pati
BACKGROUND: Proximal humeral fracture (PHF) is the fourth most common nonspinal fracture in adults. The long-term clinical outcomes after nonoperative treatment for different PHF types are unclear. This study aims to evaluate the long-term clinical outcomes of a nonoperatively treated PHF across various fracture types using the Neer and Arbeitsgemeinschaft für Osteosynthesefragen (AO) classificati
Background: The integration of clinical decision support tools in medical practice is challenging and must be carefully undertaken, especially in cancer management. Noninvasive Lymph Node Status (NILS) is a web-based tool designed to estimate the probability of benign axillary lymph nodes in female patients with breast cancer scheduled for primary surgery. The aim was to identify barriers to NILS
Musculoskeletal pain is a common complaint among children and young people, and primary care services are typically the first contact when seeking medical care. The main objective of this study was to investigate the prevalence of musculoskeletal pain in primary care among children and young people in the Skåne Region, Sweden. The annual prevalence of musculoskeletal pain in primary care was inves
Objectives Examining risk factors for erysipelas and cellulitis in adults using national registers and primary healthcare data. Methods A nationwide open cohort study including 7580,645 Swedish men and women (2001–2018) was conducted. The outcomes were erysipelas and cellulitis (skin infections). The predictors were sociodemographic factors (sex, age, education- and family income levels, region of
BACKGROUND: Variants in the KCNQ1 underlie type 1 long QT syndrome. The clinical manifestations are influenced by the specific KCNQ1 pathogenic variant.OBJECTIVE: We aimed to describe the phenotype in patients found to possess the p.Gln530Ter-KCNQ1 pathogenic variant common in Scandinavian patients with long QT syndrome.METHODS: Clinical characteristics of p.Gln530Ter-KCNQ1 variant-positive patien
BACKGROUND: Neuron-specific enolase (NSE) from 48 h after cardiac arrest is the only biomarker of brain injury with recommended cut-offs for use in neuroprognostication. Hemolysis elevates levels of NSE and may result in false outcome predictions.METHODS: A correction-factor for hemolysis in reporting of levels of NSE was established and evaluated in (1) incoming routine samples and (2) biobank sa
Background and aims Guidelines recommend measuring lipoprotein(a) [Lp(a)] at least once in all adults, but testing remains limited in clinical practice. We evaluated pragmatic strategies to maximize the immediate clinical impact of Lp(a) testing on the need of lipid-lowering treatment (LLT) in a primary prevention setting. Methods In 24,994 individuals aged 50–65 years from the population-based Sw
Background: Sex differences in the diagnostic yield of invasive coronary angiography (ICA) in non–ST-elevation acute coronary syndrome (NSTE-ACS) are well established, but contemporary population-level data incorporating high-sensitivity troponin era cohorts and cross-national validation remain limited. Objectives: The objectives of the study were to assess sex differences in diagnostic yield, rev
This chapter examines what is considered a fact in individual communications processed by the Human Rights Committee (HRC), recognized as the UN’s most authoritative human rights monitoring body. Despite its significance, little is known about the HRC’s handling of individual complaints against states that have signed the optional protocol. Through the case studies of Sanila-Aikio v. Finland (2018
Context: AI assistants, like GitHub Copilot and Cursor, are transforming software engineering. While several studies highlight productivity improvements, their impact on maintainability requires further investigation. Objective: This study investigates whether co-development with AI assistants affects software maintainability, specifically how easily other developers can evolve the resulting sourc
Biogenic volatile organic compounds (BVOCs), including isoprene, monoterpenes, and sesquiterpenes, are emitted in large quantities and play a critical role in atmospheric chemistry. They contribute to the formation of highly oxygenated organic molecules (HOM), which are essential for new particle formation (NPF) and secondary organic aerosol (SOA) formation. However, current models often oversimpl
The consideration of local knowledge in assessments and governance of biodiversity and ecosystems is a vital challenge for a just and sustainable future. This requires in-depth consideration of the intricate ways people know, engage with and are affected by natural environments. However, the concept of local knowledge is fluid, and several interpretations are in use, which can complicate construct
The outermost skin layer, the stratum corneum (SC), forms a responsive barrier where molecular transport depends on the structure and dynamics of its extracellular lipid matrix. SC lipids predominantly adopt a long-periodicity lamellar (LPP) phase across a wide hydration range, but how this structural resilience relates to the strong hydration dependence of skin permeability remains unclear. It is
