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Introduction: Despite factor (F)VIII prophylaxis, a perceived increased risk of bleeding for some people with severe haemophilia A (PwSHA) exists, limiting physical activity (PA) and restricting quality of life (QoL). Aim: HemiNorth 2 (EudraCT# 2020-003256-32) is an interventional study evaluating the impact of switching from FVIII prophylaxis to emicizumab in PwSHA without FVIII inhibitors who ha
Recent technological developments in warehousing have introduced new risks. This paper presents an integrative review that combines insights from highly automated warehouse systems (HAWS) and risk management, providing a comprehensive understanding of technology-related warehouse disruptions and vulnerabilities. We identify five major disruptions that can affect HAWS: cyberattacks, technology sabo
Biases in animal behaviour research are inevitable consequences of our societal and cultural standpoint. To remove our biases, the first stage is to identify them. We call on individual researchers to adopt a more active approach to addressing bias within their research. We propose that biases exist within a matrix defined by the general acceptance of a bias's existence and the understanding of th
This study examines the current e-learning implementation in Tanzanian universities, highlighting the challenges and opportunities associated with its utilisation. Data was collected from 610 respondents, including e-learning support staff, lecturers, and students from five selected universities through questionnaires and interviews. The findings reveal that universities in Tanzania still face imp
Background: The cold-shock domain protein YB-1 is overexpressed in pleural mesothelioma (PM) and was shown to contribute to increased cell migration and platinum resistance. Methods: Phosphorylation of YB-1 at position serine 102 was analysed by immunohistochemistry, immunofluorescence and immunoblotting in PM tissue specimens and cell lines. Intracellular localisation experiments involved immunob
Background: The increased risk of colorectal cancer (CRC) associated with family history of both colorectal in situ or invasive carcinomas (Stage 0 to IV) and colorectal polyps is attributed solely to family history of CRC, resulting in an underestimation of the actual risk. We aimed to assess the association between overall and early-onset CRC (EOCRC) risk and family history of both colorectal ca
Background: The Earth Hologenome Initiative (EHI) is a global endeavor dedicated to revisit fundamental ecological and evolutionary questions from the systemic host–microbiota perspective, through the standardized generation and analysis of joint animal genomic and associated microbial metagenomic data. Results: The first data release of the EHI contains 968 shotgun DNA sequencing read files conta
Purpose: Cardiorespiratory fitness (CRF) and muscle strength are associated with cancer risk/mortality in adults. However, there is yet no evidence for pediatric tumors. This study investigated the association of CRF and muscle strength with several tumor-related phenotypes in an aggressive childhood malignancy, high-risk neuroblastoma (HR-NB). Methods: Twelve mice bearing orthotopic HR-NB were st
Massive multiple input, multiple output (MIMO) systems are crucial for enhancing spectral efficiency and link reliability in next-generation wireless communications. However, high Peak-to-Average Power Ratio (PAPR) remains a significant challenge, leading to power inefficiencies and signal distortion. This paper presents a low complexity method for PAPR reduction using hard clipping tailored for f
Background: Infections trigger complex immune responses, with conserved as well as disease-specific characteristics. Methods: Proteomic screening technology and gene expression analysis were used here to define the immune response in infants, with their first episode of febrile urinary tract infection. Urine and peripheral blood samples were obtained at enrollment and at follow-up, after 6 months.
The study of physical systems at the microscopic scale often reveals emergent behaviors driven by thermal fluctuations and interactions. The characterization of such systems permits a deeper understanding of how these driving forces give rise to collective phenomena and functional responses. This thesis investigates two classes of microscopic systems: momentum-conserving active matter, or so-calle
The aim of this workshopreport is to move beyond existing academicdiscussions on environmental politics in North and EastSyria3, and to respond directly to the region’s urgentenvironmental needs and challenges, and to explorepossible pathways for ecological recovery and justice.We seek to critically examine the political, social, andecological dimensions of environmental governancein post-conflict
The dystrophin-glycoprotein complex (DGC) is composed of peripheral and integral membrane proteins at the muscle cell membrane that link the extracellular matrix with the intracellular cytoskeleton. While it is well established that genetic mutations that disrupt the structural integrity of the DGC result in numerous muscular dystrophies, the 3D structure of the complex has remained elusive. Two r
As the total cost of renewable electricity falls lower than the price of fossil fuel, not only can electricity be used to replace fossil fuels using batteries in vehicles but it can also be used to produce fuels. This makes it possible to replace fuels in sectors not easily directly electrified. It also provides new ways of balancing the electricity system. When renewable electricity is cheap a lo
This chapter critically examines a number of ethical dilemmas at stake for professionals working with refugee children and families in Denmark within the field of early childhood education. While national guidelines promote diversity by framing cultural differences as valuable resources, integration policies often result in efforts aimed at assimilation. The chapter explores how everyday ethical j
This article examines, firstly, how legal and safe pathways, in particular resettlement and humanitarian corridors, are regulated in French legislation and how they are implemented in practice, and secondly, the implications of this regulation and implementation for the promise of legal pathways to offer regular entry for asylum purposes. Using a legal and policy approach, our research shows that
Reactions of LXYL17 or LXYL18 (LXYL17 = α,α′-bis[((1-methyl-2-benzimidazolyl)methyl)-N-(6-methyl-2-pyridylmethyl)-amino]-m-xylene; LXYL18 = α,α′-bis[((1-methyl-2-benzimi-dazolyl)-methyl)-N-(2-pyridylethyl)-amino]-m-xylene) with [Cu(MeCN)4](ClO4) in CH2Cl2 at 298 K, subsequent exposure to dioxygen, and work-up from MeCN–MeOH, led to [CuII2(LXYL17)(μ-OMe)2](ClO4)2•0·5H2O (1) and [CuII2(L XYL18)(μ-OM
Introduction: The hepatic cytochrome P450 system includes the polymorphic CYP2D6 gene. CYP2D6 ultra rapid metabolizers (UMs) were 10-fold more common in suicide victims than in the general population in a previous study. The aim of this study was to investigate if the occurrence of the CYP2D6 UM genotype differs between subjects with and without previous suicide attempt in patients treated for dep
In order to understand and manipulate biological function at the molecular level, access to high-resolution structures of biological macromolecules is essential, as structure is intimately linked to function. The two main experimental techniques that can achieve atomic, or near-atomic, resolution are crystallography and electron microscopy. Unfortunately, the experimental data alone is typically n
