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Background and aim: The MY PD-CARE digital tool is intended to empower people with Parkinson’s disease (PD) and care partners to actively identify and track changes in key symptoms of advancing PD and to facilitate discussions with healthcare professionals (HCPs). MY PD-CARE was adapted from MANAGE-PD, a validated, web-based tool that helps HCPs identify patients with inadequate symptom control. T

In the Swedish contemporary media landscape, marked by limited financial resources, many local newspapers are searching for sustainable business models. This reality brings an unprecedented challenge: finding a balance between the market-driven demands of economic efficiency and audience expectations of trustworthy local news. A way of doing this is by writing captivating headlines that appeal to

Background: Accurate diagnosis and staging are essential for optimal treatment planning of prostate cancer. By combining functional and anatomical imaging, PSMA-PET/mpMRI offers a potential to improve lesion detection and enhance staging accuracy. This study aimed to evaluate the diagnostic performance of lesion detection and local staging of prostate cancer using combined PSMA-PET/mpMRI compared

Once surface active colloids, such as microgels, adsorb to an interface, they modify the viscoelastic properties of the interface. In contrast to what happens in bulk, the elastic properties have a non-monotonic dependence on the generalized area fraction. In this study, we describe this phenomena by performing molecular dynamic simulations of effective pair potentials in two dimensions. Our poten

BACKGROUND: Sexual violence against older adults in humanitarian settings is poorly documented, leading to gaps in prevention and delivery of support services. This study aimed to document differences in assault characteristics between younger and older adults, by sex and displacement and disability status and region. METHODS: This retrospective, descriptive observational, multi-country study incl

Background:Aseptic loosening remains a main complication following total knee arthroplasty (TKA), requiring revision surgery. Radiostereometric analysis (RSA) can assess the risk of aseptic loosening. This study evaluated the migration and segmental motion of cemented and uncemented femoral and asymmetrical tibial Persona components (Zimmer Biomet) with model-based RSA.Methods:We conducted a rando

Migratory birds have evolved a multitude of physiological and behavioural adaptations to reach their population-specific wintering areas during their first migration. The endogenous program encodes distance, direction and fuelling, and involves species-specific adaptations leading naïve migratory birds along highly diverse routes. While daylength has been extensively studied in relation to the ons

Background: Chronic subdural hematoma (CSDH) is a rapidly growing neurosurgical condition, driven primarily by an aging population and the increasing use of antithrombotic medications. Approximately 25% of CSDH patients are on anticoagulants due to atrial fibrillation (AF). The postoperative management of these patients presents a significant clinical challenge, as clinicians must balance the risk

Schistosoma japonicum (S. japonicum) infection and soluble egg antigens (SEA) can induce various immune responses, including the generation of IL-10-producing regulatory B cells (Bregs). This study investigated the dynamic changes and induction mechanisms of Bregs during S. japonicum infection. We demonstrated that CD19+IL-10+Bregs and CD19+Tim-1+ Bregs secreting IL-10 gradually increased from 6 t

Aqueous solutions are crucial in chemistry, biology, environmental science, and technology. The chemistry of solutes is influenced by the surrounding solvation shell of water molecules, which have different chemical properties than bulk water due to their different electronic and geometric structure. It is experimentally challenging to selectively investigate this property-determining electronic a

Background: The transient receptor potential melastatin 3 (TRPM3) ion channel has been implicated in sensory modulation and pain transmission and may contribute to migraine pathophysiology through calcitonin gene-related peptide (CGRP) release in the trigeminovascular system. This study aimed to investigate TRPM3 activation and its role in CGRP release, vasodilatory responses, and migraine-relevan

Sociala investeringar lanserades som ett sätt att göra välfärden mer förebyggande, rationell och långsiktigt hållbar. Genom mätbarhet, utvärdering och ekonomiska kalkyler skulle satsningar på människor legitimeras som god politik och god ekonomi. I denna artikel analyseras hur idén om sociala investeringar fick fäste i svenska kommuner – och hur samma logik som bar reformen framåt också bidrog til

Abstract: Secure base scripts are implicit schemas that guide perceptions, responses, and interactions by encapsulating expectations of support from attachment figures during distress. The current study investigated the impact of early institutional rearing and the causal effects of high-quality foster care following early deprivation on secure base scripts in adolescents who had experienced sever