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Selective Serotonin Reuptake Inhibitors (SSRIs) may reach effect concentrations in aquatic environments and disrupt serotonergic signalling in non-target invertebrates, yet mechanistic understanding remains limited. This study aimed to 1) explore the measurability of a key event associated with serotonin reuptake inhibition within a putative Adverse Outcome Pathway for SSRIs, 2) evaluate the feasi
Background Frailty is an important predictor of outcomes in patients with coronary artery disease (CAD) and following transcatheter aortic valve replacement (TAVR). The NOTION-3 (Third Nordic Aortic Valve Intervention) trial demonstrated that performing percutaneous coronary intervention (PCI) in addition to TAVR reduced the risk for major adverse cardiac events (MACE). Whether this benefit applie
The PRICKLE2 gene encodes a protein implicated in the non-canonical Wnt signalling pathway and in the regulation of planar cell polarity, although its precise biological functions remain incompletely understood. To date, only few PRICKLE2 mutations have been reported, and these have been associated with diverse clinical phenotypes, including autism spectrum disorders, epilepsy, and neurodevelopmen
AbstractBackgroundThe increasing prevalence of obesity has led to a rise in bariatric surgery as an effective intervention for weight loss and associated co-morbidities. However, concerns persist regarding increased alcohol consumption after surgery.ObjectivesTo objectively assess long-term changes in alcohol use after bariatric surgery, we used the highly specific alcohol biomarker phosphatidylet
Despite generous welfare and family policies, Sweden has a sizeable positive socioeconomic gradient in fertility; those with higher incomes have more children than those with lower incomes. While this positive socioeconomic gradient in fertility is not a new phenomenon in Sweden, a similar shift towards a positive fertility gradient is more recently seen in other high-income countries as well. Amo
Recent advances in artificial intelligence (AI) have renewed debates about the future of leadership, in particular the nature of the relationship between human leaders and intelligent machines. The literature tends to portrays human-machine relations in complementary terms: the machine does the data analysis and the number crunching while the leader makes the decisions, guided by their unique visi
In this article, we investigate how wealth evolved across social classes following land-encroachment policies implemented in Sonora in the late nineteenth century. Using a database of will inventories from Sonora, we find that the upper class saw large wealth gains following a policy shift, enabling encroachment, but not for other social groups. This indicates that access to previously indigenous
Introduction: This study investigates clinical reported challenges and ethical-professional considerations related to the use of the International Trauma Interview (ITI) and International Trauma Exposure Measure (ITEM) with trauma-affected refugees in Denmark. These instruments were implemented in 2023 across several Danish refugee rehabilitation clinics to screen for trauma and assess ICD-11 PTSD
We initiate a systematic study of TFZPP, the class of total NP search problems solvable by polynomial time randomized algorithms. TFZPP contains a variety of important search problems such as Bertrand-Chebyshev (finding a prime between N and 2N), refuter problems for many circuit lower bounds, and Lossy-Code. The Lossy-Code problem has found prominence due to its fundamental connections to derando
We study the problem of testing whether a function f:ℝⁿ → ℝ is linear (i.e., both additive and homogeneous) in the distribution-free property testing model, where the distance between functions is measured with respect to an unknown probability distribution over ℝⁿ. We show that, given query access to f, sampling access to the unknown distribution as well as the standard Gaussian, and ε > 0, we ca
We introduce and develop a new semi-algebraic proof system, called Stabbing Planes that is in the style of DPLL-based modern SAT solvers. As with DPLL, there is only one rule: the current polytope can be subdivided by branching on an inequality and its "integer negation." That is, we can (nondeterministically choose) a hyperplane a x >= b with integer coefficients, which partitions the polytope in
