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The first single-stranded DNA virus targeting Pectobacterium belongs to the family Microviridae and demonstrates a broad host range to Pectobacterium brasiliense soft rot pathogens

UNLABELLED: Pectobacterium brasiliense ( Pbr) is known to be one of the most virulent Pectobacterium species and is generally widely distributed across the globe, especially known for causing soft rot in potato-tubers and black leg in potato-plants. Currently no treatment mechanism exists, and many studies have focused on alternative treatment approaches such as biocontrol agents. Several studie

InfraVis-The Swedish Research Infrastructure for Visualization Support

Essentially all academic research of today relies on analysis of data from a wide range of sources. Several underpinning, and rapidly developing, technologies are supporting the analysis of this data. Visualization serves as an interface to this ecosystem of tools and methods and integrates them into environments supporting scientific workflows, effectively sharing cognitive load between computers

Structural Constraints, Practical Possibilities: Reflections from a Graduate School in Development Research

This essay reflects on the Development Research School, a research school launched in 2022 by Lund University, Uppsala University, the University of Gothenburg, and the University of Ghana. Using this case, the essay explores two central themes: how research schools can add value to PhD education, and the particular challenges of running such a school in the field of development research. Based on

Biogeophysical impact of land‐use scenarios on Holocene surface temperatures

Reconstructions and simulations disagree on whether the Holocene exhibited a long-term cooling or warming signal. Anthropogenic land-use could be an important forcing regionally, but available population-based estimates differ widely. We examine transient Holocene climate model simulations forced with three population-based disturbed-land reconstructions and compare this with a fourth scenario der

Evaluation of the B-lactam antibiotic concentration in the early phase of treatment of patients with suspected sepsis at the emergency department

PURPOSE: Early administration of beta-lactam antibiotics is a crucial part in the treatment of sepsis and septic shock. Beta-lactams demonstrate time-dependent killing and therefore it is important to optimize the time above the minimal inhibitory concentration (MIC). An extra dose is recommended in threatening/suspected/confirmed septic shock. This study aimed to examine whether patients with sus

Sepsis-induced coagulopathy and outcomes - What about bleeding? : A propensity score-matched study in critically ill patients with septic shock

BACKGROUND: Sepsis-induced coagulopathy (SIC) is a scoring system developed for early detection of coagulopathy in sepsis and selection of patients for interventional studies. Our aim was to define the prevalence of SIC in a critically ill population and investigate if SIC at intensive care unit (ICU) admission is associated with morbidity and mortality.METHODS: Patients admitted with septic shock

Boreal forest recovery in a changing climate : Case studies following clear-cutting and wildfire in Sweden

Boreal forests play a crucial role in the global carbon cycle and currently act as an important carbon sink. At the same time, these forests are increasingly affected by intensive forest management and a changing disturbance regime driven by climate change. Clear-cutting has been the dominant harvesting method in managed boreal forests, while wildfire, although rare over the last century in Sweden

Evaluation of gene expression-based predictors of lymph node metastasis in bladder cancer

Background: The presence of cancer in pelvic lymph nodes removed during radical surgery for muscle-invasive bladder cancer (MIBC) is a key determinant of patient outcome. It would be beneficial to predict node status preoperatively to tailor the use of neoadjuvant chemotherapy and extent of lymph node dissection. Of 12 published node status predictors based on tumor RNA expression signatures, non

Psychostimulant Effects on Motor and Cognitive Function in Adults Attention Deficit Hyperactivity Disorder (ADHD)

OBJECTIVES: This study aims to compare the performance on motor and cognitive functions of adult patients with attention deficit hyperactivity disorder (ADHD) with or without psychostimulant medication, and controls. A secondary objective is to investigate differences on test performance across varying levels of disorder severity.METHODS: We included patients with unmedicated ADHD (n=52), patients

Childhood Neighborhoods and Life-Time Fertility in Twentieth-Century Sweden. A k-Nearest Neighbor Approach

In addition to the family context, persons in the neighborhood and community are important for individual life course, socioeconomic and demographic outcomes such as education, career and family transitions. This paper aims to study how neighborhood conditions in childhood influence fertility outcomes in adulthood. Theories focusing on motivation, aspirations and attitudes or peer influence generaIn addition to the family context, persons in the neighborhood and community are important for individual life course, socioeconomic and demographic outcomes such as education, career and family transitions. This paper aims to study how neighborhood conditions in childhood influence fertility outcomes in adulthood. Theories focusing on motivation, aspirations and attitudes or peer influence genera