Filetype
National hydrogen strategies are emerging as a critical pillar of climate change policy. For homes connected to the gas grid, hydrogen may offer an alternative decarbonisation pathway to electrification. Hydrogen production pathways in countries such as the UK will involve both the gas network and the electricity grid, with related policy choices and investment decisions impacting the potential co
In an era characterised by political instability, economic uncertainty and mounting environmental pressures, hydrogen fuel is being positioned as a critical piece of the global energy security and clean energy agenda. The policy push is noteworthy in the United Kingdom, where the government is targeting industrial decarbonisation via hydrogen, while exploring a potential role for hydrogen-fuelled
As part of its efforts to secure a ‘net-zero society’, the UK government will take a strategic decision on the role of hydrogen in decarbonising homes within the next years. While scholars have recently advanced the social science research agenda on hydrogen technology acceptance, studies are yet to engage with the prospective dynamics of adopting ‘hydrogen homes’. In response, this study examines
As the global energy transition progresses, a range of drivers and barriers will continue to shape consumer attitudes and behavioural intentions towards emerging low-carbon technologies. The innovation-decision process for technologies composing the residential sector such as hydrogen-fuelled heating and cooking appliances is inherently governed by the complex interplay between perceptual, cogniti
Hydrogen energy technologies are envisioned to play a critical supporting role in global decarbonisation. While low-carbon hydrogen is primarily targeted for reducing industrial emissions, alongside decarbonising parts of the transport sector, environmental benefits could also be achieved in the residential context. Presently, gas-dependent countries such as Japan and the United Kingdom are assess
The UK Hydrogen Strategy (August 2021) and subsequent Heat and Buildings Strategy (October 2021) affirm that a strategic decision is set to be taken by 2026 on the prospect of residential decarbonisation via ‘hydrogen homes’. As this decision date draws nearer, quantitative insights on consumer perceptions of hydrogen-fuelled heating and cooking appliances remain limited. The existing knowledge de
Background: Energy hardship can be broadly understood as a situation in which individuals or households are unable to afford basic energy services necessary for sustaining their wellbeing. Despite conceptual challenges and overlaps with similar narratives (e.g., fuel poverty), the literature on energy hardship continues to expand. It represents a critical intersection with sustainable energy syste
Aims T cells are present in atrial tissue from atrial fibrillation (AF) patients. However, prospective studies of T cells and AF development are few. The current aim was to investigate if T-cell subsets are associated with the risk of developing AF. Methods and results T-cell subsets, measured by flow cytometry of cryopreserved mononuclear leucocytes isolated from blood at baseline, were analysed
Immune checkpoint inhibitors (ICIs), targeting checkpoint receptors such as programmed cell death protein 1 (PD-1), are associated with increased risk of cardiovascular events, but the underlying mechanisms remain poorly understood. Here we show that PD-1 + T cells from murine atherosclerotic aortas mainly display a progenitor exhausted phenotype (PD-1 intSlamf6 +Tim3 -), produce IFNγ in vivo, exh
Despite recent progress within the field of immuno-oncology, immune suppression in the tumor microenvironment, defective antigen presentation, and low levels of tumor-specific T cells are key limitations of current cancer immunotherapies. CD40-targeting immunotherapies hold promises for addressing these limitations across solid tumors. Here, we describe ATOR-4066, a bispecific antibody that target
Response determinants to immunotherapy in metastatic pancreatic ductal adenocarcinoma (mPDAC) remain unclear, limiting treatment advancements. We report a single-arm phase 1b/2 study (OPTIMIZE-1) evaluating the safety and efficacy of the cluster of differentiation 40 (CD40) agonist mitazalimab combined with modified FOLFIRINOX (mFOLFIRINOX), in chemotherapy-naive patients with mPDAC. Patients rece
This chapter provides an overview of how claims for state redress have been articulated by memory activists and handled by representatives of the Nordic states from the 1990s to the 2020s. The main types of historical injustices under scrutiny in these processes of “politics of regret” are enslavement and overseas colonialism, abuse in care settings, and forced assimilation of the Sámi and nationa
This article examines how Swedish social democratic women used the enactment of universal suffrage in 1919/1921 as an argument to gain support for separate organising. The article also analyses the extent to which the Swedish National Federation of Social Democratic Women, founded in 1920, used direct (personal) and indirect (media) channels for voter communication. Both scarce economic resources
A search for the exclusive hadronic decays Formula Presented, Formula Presented, and Formula Presented is performed using up to Formula Presented of proton-proton collisions recorded with the ATLAS detector at a center-of-mass energy of Formula Presented. If observed, these rare processes would provide a unique test bench for the quantum chromodynamics factorization formalism used to calculate cro
Objectives: High quality nutrition and medical nutrition therapy in long-term care (LTC) settings are essential to overcome malnutrition and ensure a better quality of life. Heterogenous and often insufficient regulations contribute to a disparity in nutritional practices across Europe. The aim of the study was to gather information on nutrition-related regulations and practices, as well as establ
According to recent lore, it is difficult to explain the evidence for a stochastic gravitational wave background obtained by pulsar timing arrays with supercooled first-order phase transitions (FOPTs). We demonstrate that supercooled FOPTs in dark U(1)′ models with a conformal dark sector easily explain the nHz signal at NANOGrav.
Objective: Previously proposed “synchronous EEG patterns” predict poor outcome within 24 h after cardiac arrest (CA). We investigate the prognostic performance of these early EEG predictors in addition to the late EEG predictors (>24 h) recommended in the European post-resuscitation guidelines. Methods: Observational substudy of the TTM2-trial including consecutive comatose resuscitated patients.
Boreal peatlands strongly affect the global climate system by providing an important store for carbon (C) cycle and a natural source of methane. Over the past century, however, vast areas of natural peatlands have been drained to gain productive land, turning them into large potential C sources. Currently, there is a scientific debate on how to best manage historically drained boreal peatlands to
