Introduction: PARP15 belongs to the PARP family, which carries out ADP-ribosylation, a post- translational modification involved in DNA repair. Finding selective inhibitors can help discover more of the role PARP15 plays in our body. Background: Inhibitors of other PARP family members, such as PARP1, have been studied because of their role in cancer processes. However, PARP15 remains poorly charac

I samband med att ett intrångsmål prövas är det inte ovanligt att svaranden invänder att den immaterialrätt som intrånget avser är ogiltig. Ett ogiltighetsförsvar kan vara ett effektivt sätt för den påstådda intrångsgöraren att retroaktivt beröva käranden den rättighet som ligger till grund för intrångstalan och, om talan ogillas, undvika ansvar. När det gäller immaterialrättsliga tvister som prIn the context of an infringement action, it is not uncommon for the defendant to object that the intellectual property right in question is invalid. An invalidity defence may be an effective strategy for the alleged infringer to retroactively deprive the right on which the plaintiff's infringement action is based and, if the court dismisses the action, thereby avoid liability. In the context

Fri rörlighet för varor och konsumentskydd utgör två centrala intressen inom EU. Emellertid är det inte ovanligt att det uppstår en konflikt mellan de två intressena. Ett exempel på en sådan konflikt är regleringen av produktmärkning på mottagarlandets språk. Regleringen av produktmärkning på mottagarlandets språk syftar främst till att skydda konsumenter genom att se till att information om en The free movement of goods and consumer protection are two key interests within the EU. However, it is not unusual that a conflict occurs between the two interests. An example of such a conflict is the regulation of product labelling in the language of the recipient country. The regulation of product labelling in the language of the recipient country primarily aims to protect consumers by ensuri

Hanteringen av barn som begår brott är ett allt mer omdiskuterat ämne, särskilt mot bakgrund av den markanta ökningen av grova våldsbrott som begås av barn under 18 år. Samtidigt som svensk gällande rätt traditionellt präglats av principen att barn inte ska fängslas, har allt fler unga frihetsberövats. Detta aktualiserar både rättsliga och etiska frågor om hur samhället bör agera när barn begår alThe treatment of children who commit crimes is an increasingly debated topic, particularly in light of a marked increase in serious violent crimes com- mitted by children under 18. While Swedish law has traditionally been char- acterized by the principle that children should not be imprisoned, the reality is that more and more young people are being deprived of their liberty. This raises both lega

The European Union is the world's second-largest contributor to global deforestation after China, primarily due to its high consumption of agricultural commodities produced outside its borders. More than one-third of the world’s remaining intact forests are on Indigenous Peoples’ lands, where development projects or logging threaten their livelihoods, cultural heritage, and traditional ways of

Sverige har länge haft en hög andel förnybar energi och är ett av de medlemsländer i den Europeiska unionen (EU) som kommit längst i sin energiomställning. För att nå EU:s klimat- och energimål samt hantera ett förändrat geopolitiskt läge har det reviderade Förnybarhetsdirektivet, (RED III) antagits. Direktivet kräver att medlemsstaterna utser så kallade accelerationsområden där tillståndsförfaranSweden has for a long period of time obtained and maintained a high share of renewable energy and is one of the member states in the European union (EU) that has made the most progress in its energy transition. To meet the EU´s climate and energy targets and address a shifting geopolitical landscape, the EU has adopted the revised Renewable Energy Directive, (RED III). The directive requires membe

AI-system integreras alltmer inom en mängd olika sektorer. AI-system kan medföra effektivisering, men kan också innebära risker för medborgerliga fri- och rättigheter. EU:s AI-förordning försöker lösa detta genom en riskbaserad metod som inför rättsliga skyldigheter för leverantörer och tillhandahållare av AI-system med hög risk. Uppsatsen analyserar AI-förordningens bestämmelser för leverantörer AI systems are increasingly integrated across numerous sectors. While AI systems can bring efficiency gains, AI systems can also entail risks to fundamental rights of citizens. The EU AI Act tries to solve this through a risk-based approach which introduces legal obligations for providers and deployers of high-risk AI systems. This thesis explores the provisions for AI providers and deployers whic

Den 8 november 2024 infördes självständigt förverkande i 36 kap. 5 § brottsbalken (1962:700) (BrB) som en del av en större reform av förverkandelagstiftningen. Förverkandeformen har huvudsakligen motiverats med att det behövs effektiva verktyg för att bekämpa den organiserade brottsligheten och neutralisera brottsvinster. Samtidigt rör det sig om ett tvångsingrepp med potentiellt långtgående konseOn 8 November 2024, non-conviction-based confiscation was introduced into Chapter 36, Section 5 of The Swedish Criminal Code (1962:700) as a part of a broader reform of the confiscation legislation. This measure has primarily been justified with regards to the need for more effective tools to combat organised crime and neutralise criminal proceeds. At the same time, it is a coercive measure with p

Denna uppsats analyserar hur nationella domstolar inom EU bör hantera digi-tal bevisning som inhämtats i andra medlemsstater, med särskilt fokus på den kontroversiella EncroChat-operationen. Genom rättsdogmatisk och kompara-tiv metod granskas rättsutvecklingen i fem EU-länder – Sverige, Frankrike, Tyskland, Nederländerna och Belgien – för att belysa spänningen mellan det ömsesidiga erkännandets krThis thesis examines how national courts within the European Union should assess digital evidence obtained in other Member States, with a particular fo-cus on the controversial EncroChat operation. Using legal dogmatic and com-parative methods, the study explores developments in five EU jurisdictions – Sweden, France, Germany, the Netherlands, and Belgium – to highlight the tension between the pri

Urban voids are not merely physical gaps on the city map. These are spaces that remain beyond programming, control, and conventional use. Often the result of economic downturns, industrial decline, or intentional neglect, such areas are frequently perceived as uncomfortable, unsafe, or unusable. Yet it is precisely their ambiguity that carries significant potential - the capacity to flexibly adap

This master’s thesis investigates the potential of applying transformation principles from the fashion industry to architectural design, specifically, how fundamental textile techniques such as seams, cuts, and slits can convert flat, two-dimensional surfaces into complex three-dimensional forms. Through a series of material experiments with these traditional methods, slits and cuts were identifie

Introduction. There is no water-tight division between different categories of human rights. In particular, it is important to note that although the project of transforming the 1948 Universal Declaration of Human Rights into treaty form culminated in separate Covenants including, on the one hand, civil and political Rights and, on the other hand, economic, social and cultural Rights, it did not r

Understanding the hydromechanical behavior of porous media such as sandstones is critical to various geoengineering applications such as geologic carbon storage, geothermal projects, oil and gas production and environmental remediation in aquifers. In these contexts, accurate quantification of the constitutive hydromechanical behavior of sandstones is necessary to predict reservoir responses. In t

En kort, Wittgensteininfluerad betraktelse i åminnelse av Karl Dahlstrand.

Background and aim. In rural areas, economic and demographic shifts often leave buildings vacant due to functional and locational obsolescence. However, these buildings hold significant value in terms of embodied energy, natural resources, economic capital, and cultural heritage. The real estate sector urgently needs innovative space use strategies and business models to tackle rising vacancy rate

Platform trials have become widely adopted across multiple disease areas over recent years, however, guidelines for operationalising these trials have not kept pace. We outline a series of documents that summarise the statistical components, and implicit processes, of the Staphylococcus aureus Network Adaptive Platform (SNAP) trial to provide an informal template for other researchers and reviewer

Purpose: Defunctioning stoma (DS) has been suggested to mitigate the consequences of anastomotic leak (AL) after low anterior resection. Stoma reversal (SR) is commonly delayed for nonmedical reasons in many healthcare systems. This study investigated the impact of the elapsed time from AR to SR on postoperative 90-day complications. The secondary aim was to explore the independent factors associa

The membranous ER spans the entire cell, creating a network for the biosynthesis of proteins and lipids, cell-wide communication, and nuclear delivery of molecules, including therapeutic agents. Here, we identify a novel ER response triggered by the tumoricidal complex alpha1-oleate, defined by a loss of peripheral ER structure, extensive ER vesiculation. Alpha1-oleate was present in the ER-derive

Background and aim.The pandemic accelerated green and digital transition may benefit smaller towns. New opportunities include multi-locational living and working, emerging industries, and novel services to attract creative industries. All these developments entail more freedom for people to choose their place of living. Meanwhile, the real estate sector is in dire need of novel space use concepts

Using detailed hand-collected data on firm ownership and board cultural diversity from Sweden, we find that foreign ownership is positively associated with board cultural diversity. This relationship is not an artifact of foreign owners joining the board, and it is not driven by firms with substantial foreign focus. The presence of foreign owners on nomination committees seems to be the channel th