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New half-sandwich complexes of pentamethylcyclopentadienyl-rhodium, iridium, and p-cymene-ruthenium have been synthesized and characterized. All metal complexes contain ligands based on a 4-chloroquinoline framework analogous to the antimalarial drug chloroquine. The first reaction in the preparation of a new ligand is a nucleophilic substitution at the chloro position of 4-chloro-7-fluoroquinolin
