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Background SLE is a systemic autoimmune disease with a large number of common risk gene variants, but several rare gene variants can cause monogenic SLE. The relationship between common and rare variants in SLE is unclear. We therefore investigated the occurrence of rare deleterious variants in patients with childhood-onset SLE (cSLE) and adult-onset SLE (aSLE) and compared the frequency of these

Rising populations are placing significant strain on traditional waste management, prompting the need for circular systems in urban projects to recycle valuable nutrients from wastewater. Introducing a biorefinery framework, microalgae cultivation on digestate effluents produces pigments for natural dyes, reducing nutrient release and offering eco-friendly alternatives to synthetic products. Succe

Atrial fibrillation (AF) is the most common heart rhythm abnormality and is a leading cause of heart failure and stroke. This large-scale meta-analysis of genome-wide association studies increased the power to detect single-nucleotide variant associations and found more than 350 AF-associated genetic loci. We identified candidate genes related to muscle contractility, cardiac muscle development an

The aim of this work is to redefine the concept of sensorimotor augmentation, extending it from wearable devices to supernumerary robotic upper limbs that are grounded and can be placed out of the physiological peripersonal space of the user. While the wearability of the supernumerary robotic limb (SRL) is not mandatory, the human-robot connection must be maintained through a wearable interface th

Background: Parathyroidectomy is typically curative for primary hyperparathyroidism (PHPT) and may lead to health-related quality of life (HRQL) improvements. We aim to evaluate general and disease-specific HRQL changes in patients undergoing surgery for PHPT from their perspective. Methods: Patients completed three patient-reported outcome measure (PROM) surveys before and after surgery: (1) Worr

In ultrarelativistic heavy ion collisions at the LHC, each nucleus acts a sources of high-energy real photons that can scatter off the opposing nucleus in ultraperipheral photonuclear ((Formula presented)) collisions. Hard scattering processes initiated by the photons in such collisions provide a novel method for probing nuclear parton distributions in a kinematic region not easily accessible to o

Purpose: To analyse the frequency and type of coexisting systemic disorders in children operated on for cataract in Sweden. Methods: Data were retrieved from the Swedish National Pediatric Cataract Register (PECARE) for children operated between January 1, 2007, and December 31, 2023 (n = 975), including follow-ups at age 1, 2, 5 and 10. Cataracts due to uveitis, trauma or radiation, and lens extr

John Maynard Keynes was nominated for the Nobel Peace Prize in the 1920s for writing “The Economic Consequences of the Peace”. Yet, despite being highly ranked by the advisor of the Nobel Committee and placed on the shortlist, he did not win. This column brings out previously unused archival material from the Nobel Committee in Oslo to explore why. The Committee tended to withhold the Prize when c

Most cutaneous malignant melanomas (CMMs) are thin (≤1.0 mm, stage T1) with an expected 10-year melanoma-specific survival of 93%–97%. The incidence of CMM is higher in groups with high socioeconomic status (SES). We aimed to assess overall survival (OS) and detailed characteristics in individuals with thin CMM as compared to the general population matched on age, sex, and county of residence. Mat

Importance: Understanding the relationship between patients' clinical characteristics and outcomes is fundamental to medicine. When critically ill patients die after withdrawal of life-sustaining therapy (WLST), the inability to observe the potential for recovery with continued aggressive care could bias future clinical decisions and research. Objective: To quantify the frequency with which expert

Purpose: Systemic amyloidosis represents a yet poorly characterized complex and multifaceted rare multisystem disease with high mortality. Clinical presentation, clinical course, and treatment vary within and across subtypes. Established biomarkers are predominantly non-specific. Diagnosis and management of these patients require specifically tailored interdisciplinary structures. Well-characteriz

Pastoral farming formed a key element of Norse subsistence strategies in South Greenland but with climatic changes of the Little Ice Age they may have reached their limit. Most recently, studies into hydrological changes across the Norse period (10th-15th century AD) revealed a severe drying trend that was coincident with the Norse demise during the early to mid-15th century AD. This study examine

This paper presents an initial technology assessment of the suitability of using aluminium as an energy carrier in shipping. The overall conclusion is that aluminium may become a suitable future energy carrier. Several advantages of using aluminium exist, including high theoretical energy densities, high resource availability, opportunity for circularity, and future potential for low lifecycle envThis paper presents an initial technology assessment of the suitability of using aluminium as an energy carrier in shipping. The overall conclusion is that aluminium may become a suitable future energy carrier. Several advantages of using aluminium exist, including high theoretical energy densities, high resource availability, opportunity for circularity, and future potential for low lifecycle env

2593Background: PD-1 blockade has demonstrated positive anti-tumor activity across multiple tumor types. While the anti-tumoral response can be substantial and even curative, response rates remain low in many cancer types. Long-lasting responses are only observed in a minority of patients, and additional immunotherapeutic alternatives remain limited for patients who fail to respond or initially re

2641Background: BI-1808 is an IgG1 mAb that target TNFR2 by blocking interaction of TNFR2 with ligand TNF-α, confers FcγR-dependent depletion of Treg and mediates expansion of intratumoral CD8+ T cells. Upon co-administration of murine surrogate antibodies targeting TNFR2 and anti-PD-1 to immunocompetent tumor-bearing mice with partial sensitivity to checkpoint blockade, complete cures were observ

Background: Selected patients with advanced germ cell tumors have a poor prognosis. These include patients with brain, bone or liver metastases, very elevated tumor markers or primary mediastinal tumor. High-dose chemotherapy (HDCT) with autologous stem cell support is recommended in the Swedish and Norwegian Testicular Cancer Group (SWENOTECA) guidelines in selected poor risk patients with poor r

BACKGROUND In the United States, Black men are at highest risk for being diagnosed with and dying from prostate cancer. Given this disparity, we examined relevant data to establish clinical prostate-specific antigen (PSA) screening guidelines for Black men in the United States. METHODS A comprehensive literature search identified 1848 unique publications for screening. Of those screened, 287 studi