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Breast cancer is a disease of genomic alterations, of which the panorama of somatic mutations and how these relate to subtypes and therapy response is incompletely understood. Within SCAN‐B (ClinicalTrials.gov: NCT02306096), a prospective study elucidating the transcriptomic profiles for thousands of breast cancers, we developed a RNA‐seq pipeline for detection of SNVs/indels and profiled a real‐w
“Responsive regulation” has been proposed to offset pharmaceutical industry illicit behaviour in areas such as drug marketing based on self- regulation backed up with threats of government sanctions. We explore the efficacy of responsive regulation by tracing recent investigations by the UK pharmaceutical industry self-regulatory authority into the firm Astellas’s illicit promotion of a top-sellin
Background: By creating ecosystems around platforms of Open Source Software (OSS) and Open Data (OD), and adopting open collaborative development practices, platform providers may exploit open innovation benefits. However, adopting such practices in a traditionally closed organization is a maturity process that we hypothesize cannot be undergone without friction. Objective: This study aims to inve
Protein denaturation in concentrated solutions consists of the unfolding of the native protein structure, and subsequent cross-linking into clusters or gel networks. While the kinetic evolution of structure has been studied for some cases, the underlying microscopic dynamics of proteins has so far been neglected. However, protein dynamics is essential to understand the specific nature of assembly
Ions are ubiquitous in nature. They play a key role for many biological processes on the molecular scale, from molecular interactions, to mechanical properties, to folding, to self-organisation and assembly, to reaction equilibria, to signalling, to energy and material transport, to recognition etc. Going beyond monovalent ions to multivalent ions, the effects of the ions are frequently not only s
Malaria is a public health problem which affects developing countries world-wide. Inadequate skilled lab technicians in remote areas of developing countries result in untimely diagnosis of malaria parasites making it hard for effective control of the disease in highly endemic areas. The development of remote systems that can provide fast, accurate and timely diagnosis is thus a necessary innovatio
The dynamics of proteins in solution includes a variety of processes, such as backbone and side-chain fluctuations, interdomain motions, as well as global rotational and translational (i.e. center of mass) diffusion. Since protein dynamics is related to protein function and essential transport processes, a detailed mechanistic understanding and monitoring of protein dynamics in solution is highly
Nowadays, an increased number of international social work (ISW) educational programs have been developed with the goal to equip practitioners to face the social problems in the new modern era. Within our globalized world, social work is in the quest for professionals with a global mind-set and nontraditional abilities and skills. This article pre- sents the findings of an explorative research car
Population ageing is one of the most challenging social, demographic and economic phenomena affecting our societies, and policy makers and researchers have been developing diverse responses to address its consequences. During the last decades, within the EU context a new concept has been developed under the label of Active Ageing (AA), intended as a tool to support efforts aimed at adapting the so
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, coronavirus disease 2019 (COVID-19), affecting more than seventeen million people around the world. Diagnosis and treatment guidelines for clinicians caring for patients are needed. In the early stage, we have issued "A rapid advice guideline for the diagnosis and treatment of 2019 n
Background: With the increased number of cancer survivors, it is necessary to explore the effect of cancer and its treatments on pregnancy outcomes, such as preterm birth, which seriously endangers the health of offspring. We aimed to explore the risk of being born preterm among offspring of cancer survivors. Materials and Methods: This is a retrospective cohort study. All singleton live births be
Solving problems that are perceptually dissimilar but require similar solutions is a key skill in everyday life. In adults, this ability, termed analogical transfer, draws on memories of relevant past experiences that partially overlap with the present task at hand. Thanks to this support from long-term memory, analogical transfer allows remarkable behavioral flexibility beyond immediate situation
Forficula auricularia (the European earwig) is possibly a complex of cryptic species. To test this hypothesis, we performed: (1) a phylogeographic study based on fragments of the mitochondrial COI and the nuclear ITS2 markers on a wide geographic sampling, (2) morphometric analyses of lineages present in Spain and (3) niche overlap analyses. We recovered five reciprocally monophyletic ancient phyl
Decreasing CO2 emissions in the building sector by improving energy efficiency isan essential part of the goal to reduce global CO2 emissions, as the sector accountedfor nearly 40 percent of the energy-related CO2 emissions in 2017.There are six main parameters that affect a building's energy use. These areoutdoor climate, building envelope properties, building services and energysystems, operatio
Höftprotesoperationer har blivit ett säkert och mycket framgångsrikt kirurgiskt ingrepp och lever upp till mycket av de förväntningar som patienterna har. Förbättring av material, protesdesign och kirurgiska tekniker har förlängt protesöverlevnaden påtagligt. Emellertid är icke optimal protesplacering och felaktigt val av komponentstorlekar känt för att öka risken för biomekaniska problem och ökatTotal hip arthroplasty (THA) has become a safe and very successful surgical intervention. A vast majority of patients get their expectations met. Improvement of materials, implant designs, and surgical techniques, have extended prosthetic survival. However, inferior placement and sizing of a hip prosthesis are known to increase the risk of mechanical failure, wear, and early loosening as well as p
