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High-grade serous ovarian carcinoma (HGSOC) is the most common subtype of ovarian cancer, often discovered in advanced stages and linked to poor survival. Due to high mortality rates, there is a need for novel treatment strategies. A promising new strategy is induction of ferroptosis, which has recently been shown to synergistically induce cell death in HGSOCs in combination with MTDH-SND1 protein

This thesis presents the development and implementation of a self-contained on-chip test framework designed to validate analog-to-digital (ADC) and digital-to-analog (DAC) converters integrated within an Application-Specific Integrated Circuit (ASIC). Utilizing the embedded ARM Cortex-M7 processor within the ASIC, the test framework eliminates reliance on external instruments by internally perform

Human behavior plays a central role in an environmentally sustainable world. Organisations also have a significant environmental impact, with many allocating resources to the development of more sustainable products and technology. However, pro-environmental behavior in the workplace is often overlooked, despite the substantial opportunity organisations have to influence it. This study encourages

High-grade serous ovarian cancer (HGSOC) is the most lethal subtype of ovarian cancer and remains a major clinical challenge due to frequent late diagnosis and limited treatment options. This study investigates the therapeutic potential of targeting the oncogenic interaction between metadherin (MTDH) and staphylococcal nuclease domain-containing 1 (SND1) which are proteins known to promote tumor p

Skåne universitetssjukhus i Lund är idag belagt på Getingevägen men ska efter beslut från Region Skåne och Lunds kommun flyttas till Smörlyckan i Lund. Byggstart är planerad från 2030 och färdigställande 2045. Eftersom Smörlyckan ligger längre från stadskärnan än nuvarande sjukhus, behöver ett hållbart och effektivt kollektivtrafiksystem utvecklas för att säkerställa ett bra transportsystem till SThe Skåne University Hospital in Lund is currently located along Getingevägen but, following decisions by Region Skåne and the City of Lund, will be relocated to Smörlyckan. Construction is planned to start in 2030 with completion by 2045. Since Smörlyckan is situated farther from the city center than the current hospital, a sustainable and efficient public transport system needs to be developed t

This thesis explores the function of compulsory licensing established by the World Trade Organisation’s TRIPS Agreement, which serves as a legal means to enhance access to essential medications in low-income countries. The study examines the conflict between intellectual property rights and the right to health, highlighting the flexibilities within TRIPS and their interpretation as emphasised in t

This study investigates the dynamic response of a glass pane under impact loading utilizing modal analysis and Newmark’s method. The benefits and drawbacks of modal analysis as well as Newmark’s method in this context are also investigated. The study aims to simulate the testing of glass panes according to the testing method described in SS-EN 12600 where an impact device is swung in a pendulum mo

This thesis investigates the economic impacts of the 2018-2019 US-China trade war on Sweden. Given that Sweden is a small, open economy deeply embedded in global supply chains, the study explores how external trade tensions influenced domestic consumer and producer welfare. Using monthly time series data from 2016 to 2022, the analysis focuses on key trade-related price indices (Export Price Index

Water for Injection (WFI) is a critical utility in pharmaceutical manufacturing, traditionally produced through an energy-intensive distillation process. This thesis investigates the feasibility of a more sustainable alternative, ambient WFI production using membrane-based purification technologies combined with ozonation in the storage and distribution loop. Conducted in collaboration with AstraZ

Japan drabbas ofta av svåra naturkatastrofer, där jordbävningar och tsunamier orsakar omfattande förödelse. Efter sådana händelser kan arkitektoniska strategier bidra både till att återuppbygga fysisk infrastruktur och stödja människors psykosociala återhämtning. Arkitektonisk resiliens definieras som byggnaders förmåga att hjälpa samhället att återgå till balans efter kraftiga störningar. DessutoJapan is frequently struck by severe natural disasters, whereas earthquakes and tsunamis inflict widespread devastation. In their aftermath, architectural strategies can help rebuild physical infrastructure while supporting survivors psychosocial recovery. Architectural resilience is defined as a building´s capacity to help society regain equilibrium after major disruptions. Moreover, the physical

I takt med att generativa AI-verktyg som ChatGPT blir allt vanligare inom högre utbildning, väcks nya frågor om deras faktiska roll i att stödja studenters självständiga lärande. Tidigare forskning har i stor utsträckning lyft fram teknologins potential, men har i lägre grad fokuserat på dess begränsningar ur studenternas perspektiv. Denna studie undersöker vilka behov i det självständiga lärandet

Efforts to regulate transnational corporations in the context of human rights are not new. They traced back to the early 1970s, when the United Nations first initiated attempts to study the impact of transnational corporations on the international development process and proposed a United Nations Code of Conduct on Transnational Corporations, an initiative that ultimately stalled. A renewed attemp

Denna studie undersökte attityder till barnfrihet i en svensk kontext, med särskilt fokus på hur barnfria kvinnor upplevde reaktioner från sin omgivning. En mixed-methods-design tillämpades. En kvantitativ enkätstudie (n = 131) mätte attityder med hjälp av en modifierad version av Attitudes Toward Voluntary Childlessness Scale. Resultaten visade att kvinnor uttryckte signifikant mer positiva attitThis study examined attitudes toward voluntary childlessness in Sweden, with a specific focus on how childfree women experience social reactions. A mixed methods approach was employed. A quantitative survey (n = 131) measured attitudes using a modified version of the Attitudes Toward Voluntary Childlessness Scale. Results showed that women held significantly more positive attitudes towards volunta

Coronapandemin ledde till en kraftig och varaktig ökning av distansarbete. Trots fördelar har det också förstärkt utmaningen med den ensamhet som ofta följer med att arbeta hemifrån. Tidigare forskning har främst fokuserat på organisatoriska strategier för att motverka detta, men kunskapen om hur distansarbetare själva hanterar känslor av ensamhet är fortfarande begränsad. Den här studien använderThe COVID-19 pandemic created a significant and ongoing rise in remote work, which, despite its benefits, has amplified the challenge of loneliness for many remote employees. While previous research has largely examined organizational strategies to combat this issue, a gap remains in understanding the independent coping mechanisms employed by remote workers themselves. This study employed a netnog

This thesis explores the potential of generative AI to recreate biological spatial systems, using termite mound structures as inspiration. Termite mounds, known for their unique internal networks and passive climate regulation, feature complex spatial logics that challenge traditional modeling techniques. This project investigates whether diffusion-based generative models can be trained to mimic s

In the face of a potential oncoming environmental collapse, in a time of increasing climate anxiety and activist disillusionment towards previous environmental efforts, I look at how a radical environmental activist group becomes and stays radical. By combining deviant and dramaturgical perspectives on social movements with Goffman’s classic work "The Presentation of Self in Everyday Life&quo

Mörk materia, den osynliga och hypotetiska formen av materia som förutsägs av våra bästa teorier, har än så länge undkommit våra mest direkta detektionsförsök vilket har motiverat fysiker till att komma på nya och desto mer invecklade sätt att ta reda på dess sanna natur. Ett sådant sätt som verkar ha fångat samtligas intresse på senare år är möjligheten att detektera gravitationsvågor som skapatsWe perform a comprehensive cosmological analysis of stable scalar glueballs arising in pure SU(N) Yang-Mills theories focusing on N=3,4,5 which serve as natural candidates for models of self-interacting dark matter. The key characteristic of these theories is that they exhibit strong first-order confinement-deconfinement phase transitions which would give rise to a stochastic gravitational wave ba

Against the backdrop of the accelerated advancement of a new round of technological revolution and industrial transformation, the global economy is moving towards a development model driven by innovation as its core. Enterprises, as important carriers of technological progress and institutional innovation, are facing increasingly fierce market competition and transformational pressures. In this pr