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Characterizing the onset and progression of Alzheimer’s disease pathologies relative to one another is important for biological staging and clinical trial design. Recent advances in blood plasma assays of Alzheimer’s disease amyloid and tau pathology have enabled detection of Alzheimer’s disease pathophysiology during life, but it remains unclear when plasma biomarker abnormalities are detectable
This study investigates how rescue service response times and staffing solutions relate to both citizen satisfaction with rescue services and the adoption of individual fire safety measures in Sweden. Data were drawn from Statistics Sweden's satisfaction index, rescue service response times from KOLADA, and survey data from the Swedish Civil Contingencies Agency on ownership of functional smoke de
In many research fields of the social sciences, attempts have been and are being made to integrate Darwinian evolutionary theory into their own work. The motivation and benefits of integration can vary from field to field and range from considering biological foundations for social phenomena to the application of methods and study designs from outside the field. Furthermore, Darwinian evolutionary
Endoscopically, the villi of the small bowel in intestinal lymphangiectasia typically appear white and may be swollen. Less commonly, tiny white spots are visible in the mucosa. The whitish discoloration of the villi is caused by chylomicrons, which accumulate in and obstruct the dilated lymphatic capillaries. These changes can also be demonstrated histologically. Lymphangiectasia is characterized
Network analysis has been recently adopted by the field of psychology to explore networks of symptoms in psychopathology, and wider interactive networks of biological, behavioral, and psychological factors influencing mental health. The network theory of psychopathology conceptualizes symptoms of mental disorder as causally connected, rather than being caused by disease or an underlying latent var
Background:Serious illness conversations are an iterative, interprofessional, team-based process that includes recommendations about medical care. Yet, it is not clear how clinicians in different role groups work together in this process.Objectives:We sought to examine how interprofessional clinicians in the medical intensive care unit (MICU) who were trained in the serious illness care program (S
Editorial for the special issue of "Small Structures"
Disorder is an intrinsic feature of all solids, from crystals of atoms to superlattices of colloidal nanoparticles. Unlike atomic crystals, in nanocrystal superlattices, a single misplaced particle can affect the positions of neighbors over long distances, leading to cumulative disorder. This elusive form of collective particle displacement leaves clear signatures in diffraction, but little i
BACKGROUND: We hypothesized that the main barriers to integrating exercise in routine care of patients with chronic kidney disease (CKD) were structural within European healthcare systems rather than due to resistance among healthcare professionals or patients.MATERIALS AND METHODS: This descriptive cross-sectional study used anonymized questionnaires to investigate nurses' and physicians' attitud
This study investigated the retention of spatial knowledge in buildings following route-learning training in a virtual reality environment. A total of 121 participants were tested up to three months later on putting waypoints of the route in the correct order and recalling directions at waypoints. Memory accuracy declined over time, consistentwith classic memory theory. Route knowledge was retaine
Background/Aim: Circumferential resection margin (CRM) has been shown to be a strong predictor of risk of local recurrence (LR) and distant metastases (DM) in patients with rectal cancer treated with total mesorectal excision (TME). However, not all patients with a CRM of zero develop LR or DM. This study aimed to identify factors associated with disease-free survival (DFS) despite non-radical exc
Purpose: High-risk colon cancer may benefit from preoperative chemotherapy (preCHT), but evidence on its short-term safety and outcome is limited. Population-based evidence before its incorporation into national guidelines is lacking. Methods: Patients with final weighted stage II–III colon cancer undergoing elective resection between 2007 and 2017 were identified in the Swedish Colorectal Cancer
AIM: This retrospective observational cohort study aimed to investigate the prevalence of suspected lateral lymph node metastases (LLNM), as diagnosed by magnetic resonance imaging (MRI), and its impact on local recurrence (LR) and overall survival (OS). Patients who underwent dissection of suspected lymph nodes were evaluated in subgroup analysis.METHOD: Patients diagnosed with rectal cancer in S
Objective To characterize the redistribution patterns of zinc and calcium ions during human sperm capacitation and to investigate their roles in sperm maturation and fertilization. Design In vitro experimental study using synchrotron-based x-ray fluorescence microscopy and complementary immunohistochemistry to assess elemental changes during different capacitation stages at nanometric spatial reso
This is a paper about gymnastics and a primordial form of geological knowledge. It pursues an interpretation of gymnastics, broadly defined, as a philosophy that interrogates what the Earth is. The goal is to reconstruct the epistemic implications of gymnastic practice in order to understand the evolution of animal motility as a prototypical form of geological knowledge. Since gravity is a global
BackgroundHeart failure (HF) and arterial hypertension (AH) are strongly associated with obesity, with a linear relationship to increasing body mass index (BMI). However, some individuals with obesity do not exhibit signs of HF or AH.PurposeThis study aimed to compare, for the first time in a large population-based cohort, individuals with obesity who have normal left ventricular function and remo
Acquired diverticula of the small bowel are mainly located in the duodenum, followed by the jejunum. They are typically asymptomatic, but may occasionally cause massive bleeding, diverticulitis, and even perforation. Meckel’s diverticula are a remnant of the omphalomesenteric duct located in the ileum. They can cause overt bleeding, typically in children, but also in adults. Sensitivity of Meckel’
Benign tumours of the small intestine consist of various rare entities such as tumour-like inflammatory or hyperplastic lesions, hamartomas (organoid malformations), ectopic tissues, and true neoplasms of epithelial or mesenchymal origin. These benign tumours often stay asymptomatic for years, with small lesions frequently remaining undiscovered. They may be manifested clinically by bleeding, iron
This dissertation is about social change ‘and’, ‘with’, as well as ‘through’ food. It examines the rise and expansion of novel approaches to veganism and plant-based lifestyles in the Sino-cultural sphere by foregrounding the assemblage of actors (human and nonhuman) at the forefront of this phenomenon. While East Asia, and more specifically Sinophone societies like China and Taiwan, have long-est
Many theories based on Darwinian evolutionary theory are of particular relevance to family research. The theory of kin selection is not limited to social behavior of animals, but also explains why humans in all cultures and epochs organize their reproductive and productive activities in family networks and family households. Even though the willingness to cooperate in the human family ultimately g
