Novel biomarkers are key to addressing the ongoing pandemic of type 2 diabetes mellitus. While new technologies have improved the potential of identifying such biomarkers, at the same time there is an increasing need for informed prioritization to ensure efficient downstream verification. We have built BALDR, an automated pipeline for biomarker comparison and prioritization in the context of diabe

BACKGROUND: Numerous laboratory tests are used in the diagnosis and management of patients with diabetes mellitus. The quality of the scientific evidence supporting the use of these assays varies substantially. An expert committee compiled evidence-based recommendations for laboratory analysis in patients with diabetes. The overall quality of the evidence and the strength of the recommendations we

In May 2023, the U.S. FDA advisors endorsed Pfizer’s pregnancy-administered vaccine (branded ABRYSVO) to protect infants from respiratory syncytial virus (RSV) infection. Vaccination can reduce the burden of RSV-related respiratory disease, with previous studies showing its substantial medical and financial burden in Jordan. However, pregnant women may exhibit hesitancy to get vaccinated due to co

Rationale: We recently demonstrated that patients with coronary artery disease (CAD) and obstructive sleep apnea (OSA) carrying the tumor necrosis factor-alpha (TNF-α) A allele had increased circulating TNF-α levels compared with the ones carrying the TNF-α G allele. In the current study, we addressed the effect of TNF-α (-308G/A) gene polymorphism on circulating TNF-α levels following continuous

Importance: Endovascular treatment is not recommended for aortic pathologies in patients with connective tissue diseases (CTDs) other than in redo operations and as bridging procedures in emergencies. However, recent developments in endovascular technology may challenge this dogma. Objective: To assess the midterm outcomes of endovascular aortic repair in patients with CTD. Design, Setting, and Pa

Existing epidemiological evidence regarding the potential role of (poly)phenol intake in prostate cancer (PCa) risk is scarce and, in the case of flavonoids, it has been suggested that their intake may increase PCa risk. We investigated the associations between the intake of the total and individual classes and subclasses of (poly)phenols and the risk of PCa, including clinically relevant subtypes

Background Statistical analyses of clinical data are a cornerstone in understanding pathomechanisms of disorders. In rare disorders, cross-sectional datasets of sufficient size are usually not available. Taking AA amyloidosis as an example of a life-threatening rare disorder resulting from of uncontrolled chronic inflammation, we propose techniques from time series analysis to predict organ respon

Polycotylid and elasmosaurid plesiosaurs inhabited the Kristianstad Basin during Late Cretaceous (uppermost lower Campanian Belemnellocamax mammillatuszone) around 80 million years ago. The setting represents one of the most famous Mesozoic fossil sites in Scandinavia. The Kristianstad Basin fossils are generally fragmentary and isolated due to high-energy environments in a protected shallow innerPolycotylid and elasmosaurid plesiosaurs inhabited the Kristianstad Basin during Late Cretaceous (uppermost lower Campanian Belemnellocamax mammillatuszone) around 80 million years ago. The setting represents one of the most famous Mesozoic fossil sites in Scandinavia. The Kristianstad Basin fossils are generally fragmentary and isolated due to high-energy environments in a protected shallow inner

Critical StagesUnstable Grounds: Reconfigurations of Performance and PoliticsSpecial Issue, June 2021Gigi Argyropoulou and Stefanie SachsenmaierThis issue explores operations of performance during unstable conditions marked by socio-political, environmental, economic and further challenges. It is particularly interested in histories, reconfigurations and mutations of performance practice as it see

Introduction: Contact allergy to nickel (Ni) is a delayed-type hypersensitivity reaction mediated by Ni-reactive T cells producing the hallmark cytokines of several T-helper cell (Th) populations including IFN-γ(Th1), IL-4, IL-5 and IL-13 (Th2), and IL-17A (Th17). IL-22-expressing CD4+ cells, which could be either Th17 co-expressing IL-22 or Th22, expressing IL-22 in the absence of IL-17A, have al

BACKGROUND: Sotalol and dronedarone are both used for maintenance of sinus rhythm for patients with atrial fibrillation. However, while sotalol requires initial monitoring for QT prolongation and proarrhythmia, dronedarone does not. These treatments can be used in comparable patients, but their safety and effectiveness have not been compared head to head. Therefore, we retrospectively evaluated th

Word formation processes frequently lead to systematic interactions between morphology and prosody (e.g., stress or speech melody). In this manner, the prosody on a word stem often changes when endings are added – either through inflection, derivation, or compounding. Native speakers exploit this relation between prosody and morphology during speech perception. On the one hand, they can use the pr

While there is growing awareness that knowledge of regional minority languages must be protected, assessing the vitality of such varieties is challenging due to the lack of assessment materials. Our contribution documents the creation and validation of LexVEN, a bimodal yes/no vocabulary task, with the purpose of assessing the proficiency of users of Venetan with receptive and/or productive skills

In many civil engineering problems, soil is stabilized by a combination of binders and water. The success of stabilization is evaluated using seismic tests with measured P-wave velocities. Optimization of process, laboratory testing and data modelling are essential to reduce the costs of the industrial projects. This paper reports the optimized workflow of soil stabilization through evaluated effe

We discovered nocturnal colour vision in the Asian giant honeybee Apis dorsata - a facultatively nocturnal species - at mesopic light intensities, down to half-moon light levels (approx. 10 -2 cd m -2). The visual threshold of nocturnality aligns with their reported nocturnal activity down to the same light levels. Nocturnal colour vision in A. dorsata is interesting because, despite being primari