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Bimetallic nanoparticles exhibit unique physicochemical characteristics that often translateinto functional properties surpassing those of their monometallic counterparts. The abilityto precisely tailor these characteristics enables fine-tuning of their properties for targetedapplications. This doctoral thesis investigates the engineering of bimetallic nanoparticlesvia spark ablation, a continuous
Climate change is strongly linked to the quantity of carbon dioxide (CO2) released by burning fossil fuels, which contain carbon. To address the problem, ammonia (NH3) has recently gained significant attention as a potential alternative fuel due to its carbon-free nature, ease of storage, and good energy density. However, ammonia combustion in practical devices presents challenges, particularly it
Rapporten undersøger, hvordan streaming påvirker danske forfatteres økonomi og vilkår med fokus på forskelle mellem genrer, udgivelsesstrategier og markedspositioner. Streaming medfører overordnet, at man går fra sælge en vare (en bog) i boghandlen, til at sælge adgang til et katalog af bogtitler på en streamingplatform. Forlag og forfattere får betaling for værket baseret på brug, det vil sige, h
Diffusion magnetic resonance imaging (dMRI) is a powerful non-invasive technique for probing tissuemicrostructure. While highly sensitive, conventional dMRI methods suffer from low specificity, due in part toexperimental designs that conflate multiple contrast mechanisms. This thesis aims to address these limitations bydeveloping advanced time-dependent dMRI techniques to disentangle competing sou
The supramolecular structures resulting from the complexation between the neutral-cationic block copolymer poly(ethylene oxide)- block-poly(2-(trimethylammonium)ethyl methacrylate iodide) (PEO 114- b-PTMAEMAI 95) and the bile salt sodium deoxycholate (NaDC) were investigated by dynamic light scattering, small-angle X-ray scattering, cryogenic transmission electron microscopy and proton NMR techniq
Risk factors for developing bloodstream infections (BSIs) caused by Aerococcus bacteria remain insufficiently examined. In this nationwide case–control study in Sweden, 19 of 23 clinical microbiological laboratories identified patients who had aerococcal BSIs during 2012–2016. We compared each of those index patients with 4 controls matched for age, sex, and county of residence. Overall, 588 episo
In this paper, we propose an adaptive finite difference scheme in order to numerically solve total variation type problems for image processing tasks. The automatic generation of the grid relies on indicators derived from a local estimation of the primal-dual gap error. This process leads in general to a non-uniform grid for which we introduce an adjusted finite difference method. Further we quant
Quasi-markets in the provision of public services are increasingly common but also highly contested. We formulate a conceptual framework based on economic theory to describe how quasi-markets differ from traditional markets in five aspects: 1) revenues, costs, and profits; 2) the matching of supply and demand; 3) competition; 4) structural change; and 5) rent-seeking. Using the assumption of profi
Under slutet av 1900-talet var den svenska reformtakten hög vilket gjorde ekonomin konkurrenskraftig och att Sverige klarade finanskrisen 2008–2010 bättre än jämförbara länder. Nu har reformtakten avtagit och den ekonomiska friheten är fallande på flera områden. I en ny rapport från Entreprenörskapsforum konstateras att 2010-talet blev ett i allt väsentligt förlorat decennium med minskad ekonomisk
Understanding the structure of supramolecular complexes provides insight into their functional capabilities and how they can be modulated in the context of disease. Super-resolution microscopy (SRM) excels in performing this task by resolving ultrastructural details at the nanoscale with molecular specificity. However, technical limitations, such as underlabelling, preclude its ability to provide
The maker movement has reached the optics labs, empowering researchers to create and modify microscope designs and imaging accessories. 3D printing has a disruptive impact on the field, improving accessibility to fabrication technologies in additive manufacturing. This approach is particularly useful for rapid, low-cost prototyping, allowing unprecedented levels of productivity and accessibility.
In the vicinity of metallic nanostructures, absorption and emission rates of optical emitters can be modulated by several orders of magnitude1,2. Control of such near-field light-matter interaction is essential for applications in biosensing3, light harvesting4 and quantum communication5,6 and requires precise mapping of optical near-field interactions, for which single-emitter probes are promisin
Interrogating platelets and their densely packed, highly abundant receptor landscape is key to understand platelet clotting, a process that can save lives when stopping blood loss after an injury, but also kill when causing heart attack, stroke, or pulmonary embolism. The underlying key receptor distributions and interactions, in particular the relevance of integrin clustering, are not fully under
Single-molecule localization microscopy (SMLM) aims for maximized precision and a high signal-to-noise ratio1. Both features can be provided by placing the emitter in front of a metal-dielectric nanocoating that acts as a tuned mirror2-4. Here, we demonstrate that a higher photon yield at a lower background on biocompatible metal-dielectric nanocoatings substantially improves SMLM performance and
We propose symmetrical cationic trimethine cyanine dyes with β-substituents in the polymethine chain based on modified benzothiazole and benzoxazole heterocycles as probes for the detection and visualization of live and fixed cells by fluorescence microscopy. The spectral-luminescent properties of trimethine cyanines have been characterized for free dyes and in the presence of nucleic acids (NA) a
The unicellular eukaryote Saccharomyces cerevisiae is an invaluable resource for the study of basic eukaryotic cellular and molecular processes. However, its small size compared to other eukaryotic organisms the study of subcellular structures is challenging. Expansion microscopy (ExM) holds great potential to study the intracellular architecture of yeast, especially when paired with pan-labelling
DNMT3A/3L heterotetramers contain two active centers binding CpG sites at 12 bp distance, however their interaction with DNA not containing this feature is unclear. Using randomized substrates, we observed preferential co-methylation of CpG sites with 6, 9 and 12 bp spacing by DNMT3A and DNMT3A/3L. Co-methylation was favored by AT bases between the 12 bp spaced CpG sites consistent with their incr
