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Clinical use of polygenic scores in type 2 diabetes: challenges and possibilities

Resulting from a combination of genetic and environmental factors, type 2 diabetes is highly heterogeneous in manifestation and disease progression, with the only common feature being chronic hyperglycaemia. In spite of vigorous efforts to elucidate the pathogenetic origins and natural course of the disease, there is still a lack of biomarkers and tools for prevention, disease stratification and t

High Hopes and Hard Lessons : How Problems Are Represented in Swedish Teacher Education Reform

In this paper, I draw on my background as an educational scientist with roots in sociology and gender studies to explore how public debate, political reforms, and policy documents shape Swedish teacher education with the aim of reforming not only the school system but also Swedish society. Historically, teacher education in Sweden has been influenced by visionary ideals, particularly with the intr

High-fidelity 3D live-cell nanoscopy through data-driven enhanced super-resolution radial fluctuation

Live-cell super-resolution microscopy enables the imaging of biological structure dynamics below the diffraction limit. Here we present enhanced super-resolution radial fluctuations (eSRRF), substantially improving image fidelity and resolution compared to the original SRRF method. eSRRF incorporates automated parameter optimization based on the data itself, giving insight into the trade-off betwe

The Association Between Women's Perception of Birth During the Pandemic, Companion of Choice and Support From Health Professionals : A Cross-Sectional Study in 20 Countries in the WHO European Region

BACKGROUND: Mitigation measures implemented in response to the COVID-19 pandemic led to significant changes in maternity care across Europe, including restrictions on companions during labor and birth. This cross-sectional study explores the association between the presence of a companion of choice and a positive perception of the birth experience. Additionally, it explores the association between

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The current linear economic system is based on the extraction of natural resources, the transformation of raw materials and the disposal of waste, leading to the environmental and economic depletion of resources and society. The circular economy proposes the circularity of materials, evaluating post-consumption waste and proposing a waste hierarchy called preparation for reuse (PfR), as set out in

Technological competencies and firm performance : analyzing the importance of internal and external competencies

In this paper, we analyze the relationship between technological competencies (TC) and firm performance. Theoretically, the importance of TC is well established and widely accepted. Therefore, it is surprising that a number of empirical studies have been unable to confirm a substantial positive relationship between TC and firm performance. We identify two major reasons for this: [i] affected by th

Memory and Identity in the Emotive Map of Alain Resnais’ Hiroshima Mon Amour (1959)

The focus of this article is Alain Resnais’ representation of collective and individual memory and identity in Hiroshima Mon Amour (1959). The film is based on Marguerite Duras’ script from 1958 and remains faithful to this original text. With partial reference to Giuliana Bruno’s views on imaginary cities and urban cartography, the screened urban space will here be read as an emotive map in which

Bacterial transcriptional repressor NrdR – a flexible multifactorial nucleotide sensor

NrdR is a bacterial transcriptional repressor consisting of a zinc (Zn)-ribbon domain followed by an ATP-cone domain. Understanding its mechanism of action could aid the design of novel antibacterials. NrdR binds specifically to two “NrdR boxes” upstream of ribonucleotide reductase operons, of which Escherichia coli has three: nrdHIEF, nrdDG and nrdAB, in the last of which we identified a new

Effect of starch structuring and processing on the bioaccessibility of polyphenols in starchy foodstuffs : A review

Starch is the main polysaccharide in the human diet and is the major calory supplier. The digestibility of starch can be controlled by processing conditions, which produce the rearrangement of the polymer's multi-scale structure and interactions with other components in the food matrix. The interest in consuming functional foods with polyphenols is linked to the pursuit of overall well-being. Stil

"Humanity is on thin ice and that ice is melting fast" - Climate-Induced Displacement: Legal Complexities and the Search for Solutions

Klimatförändringarna tvingar miljontals människor världen över att lämna sina hem, men det juridiska skyddet för dem som flyr miljörelaterade kriser är fortfarande otydligt och fragmenterat. 1951 års flyktingkonvention erbjuder viktiga skydd för personer som flyr förföljelse, men omfattar inte individer som fördrivs av klimatförändringar, vilket skapar betydande luckor i den internationella rättenClimate change is displacing millions globally, yet legal protections for those fleeing environmental crises remain unclear and fragmented. The 1951 Refugee Convention offers critical safeguards for those fleeing persecution but excludes individuals displaced by climate change, leaving significant gaps in international law. This raises pressing questions: How can international law address the chal

Förslaget om säkerhetsstraff - En kritisk analys mot bakgrund av påföljdsbestämningens grundläggande syften och principer

I juli 2024 lämnade Utredningen om påföljder, återfall och verkställighet sitt betänkande, SOU 2024:48, vari ett förslag är att införa en preventivt inriktad tidsobestämd frihetsberövande påföljd, så kallat säkerhetsstraff. Syftet med förslaget är att i särskilt allvarliga situationer, när påföljden inte kan bestämmas till fängelse på livstid eller rättspsykiatrisk vård, ändå kunna frihetsberöva eIn July 2024, the Inquiry on Sanctions, Recidivism, and Enforcement submit-ted its report, SOU 2024:48, which includes a proposal to introduce a preventively oriented, indefinite deprivation of liberty as a sanction, referred to as a security sentence. The purpose of the proposal is to enable the indefinite detention of an offender in particularly serious situations, where the sanction cannot be d

Wireless Presence Detection

Närvarodetektion som säkerhetssystem Maskinsäkerhet säkerställs ofta med klumpig och hindrande utrustning, vilket kan vara opraktiskt i många sammanhang. Genom att istället trädlöst identifiera och särskilja olika operatörer kan utrustningen avgöra om det är säkert eller ej att starta olika processer på ett smidigare sätt. För att kunna implementera den trådlösa närvarudetektionen som krävs förWireless communication encompasses a wide range of applications, demonstrating its versatility in various domains. For example, it can be utilized to enable access control through the use of tags, act as a deterrent against theft in retail settings, or support global and interstellar communication. What all of the different use cases have in common is that they work by employing radio frequency tr

Decision Support System in Hydrological Modeling - A case study in China

Generally speaking, Computer based numerical hydrological models have been playing a very central role during the last decades in dealing with water resources related problems. Various kinds of conceptual, physical and stochastical models have been developed. Perhaps the most important contribution of those models is the ability of simplifying and schematizing a complex problem in the nature and s

Disinfection and Fresh-Keeping of Rainwater in Small Scale Cisterns

Various disinfectants are examined in a study for disinfection and fresh-keeping of collected rainwater in cisterns in arid areas of China. Among the tested disinfectants (chlorine, ozone, chlorine dioxide, potassium permanganate, chloramines and hydrogen peroxide etc.), chlorine dioxide has proved to be the most feasible and effective oxidant for drinking water storage and disinfection of rainwat