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Common polymorphisms in the solute carrier SLC30A10 are associated with blood manganese and neurological function.

Manganese (Mn) is an essential nutrient in humans, but excessive exposure to Mn may cause neurotoxicity. Despite homeostatic regulation, Mn concentrations in blood vary considerably among individuals. We evaluated if common single-nucleotide polymorphisms (SNPs) in SLC30A10, which likely encodes a Mn transporter, influence blood Mn concentrations and neurological function. We measured blood Mn con

Hypoxia-mediated induction of the polyamine system provides opportunities for tumor growth inhibition by combined targeting of vascular endothelial growth factor and ornithine decarboxylase.

Hypoxia is a hallmark of solid tumors, which may offer opportunities for targeted therapies of cancer; however, the mechanisms that link hypoxia to malignant transformation and tumor progression are not fully understood. Here, we show that up-regulation of the polyamine system promotes cancer cell survival during hypoxic stress. Hypoxia was found to induce polyamine transport and the key enzyme of

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Modelling of mechanical properties of wood and wood based materials

Modelling is a wide concept. This paper describes various meanings of modelling in relation to mechanical properties of wood and wood-based materials. Three examples of modelling by means of the finite element method, presented in recent years in PhD theses, are used as reference points. They relate to modelling of the micro-structure of wood and its mechanical properties, modelling of drying-indu

Numerical evaluation of different landfill daily cover in semiarid areas – Jordan

Efficient and suitable daily landfill cover is considered the most important aspect for minimising the negative impact of landfills on the local environment and population, especially in arid and semiarid countries. In this study, numerical model, HYDRUS-2D/3D, was used to investigate the impact of landfill cover type, cover thickness and antecedent water content on the quantity and the rate of co

Bone mineral density in the hand as a predictor for mortality in patients with rheumatoid arthritis.

Objectives. BMD in the hand, as evaluated by digital X-ray radiogrammetry (DXR), has been suggested to be a predictor for joint damage in RA. A predictor for long-term prognosis might also predict increased mortality in RA. The aim of the present study was to evaluate BMD in the hand as a predictor for all-cause mortality. Methods. In 1978, 152 consecutive patients (78% women, mean disease duratio