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The spatio-temporal scale of design for sustainability has come full circle. What started within a technology-oriented global outlook, later evolving into a people-oriented and local view on change, now urges for a holistic, broad extent and multilevel design for sustainability. This paper enquires into the theories of social change that govern different approaches within the field, and positions
Rubella virus encodes a nonstructural polyprotein with RNA polymerase, methyltransferase, and papain-like cysteine protease activities, along with a putative macrodomain of unknown function. Macrodomains bind ADP-ribose adducts, a post-translational modification that plays a key role in host-virus conflicts. Some macrodomains can also remove the mono-ADP-ribose adduct or degrade poly-ADP-ribose ch
This anthology explores the memory work performed by Baltic and Central and East European far-right actors in the online space. Situated at the crossroads between memory studies, far-right studies, and media studies, the volume’s seven chapters show how a wide range of far-right actors, from small movements to major parties, have exploited digital communication technologies in order to establish t
This paper argues that praise is governed by a norm of standing, namely the evaluative commitment condition. Even when the target of praise is praiseworthy and known to be so by the praiser, praise can be inappropriate owing to the praiser's lacking the relevant evaluative commitment. I propose that uncommitted praisers lack the standing to praise in that, owing to their lack of commitment to the
A multi‐material topology optimization scheme is presented. The formulation includes an arbitrary number of phases with different mechanical properties. To ensure that the sum of the volume fractions is unity and in order to avoid negative phase fractions, an obstacle potential function, which introduces infinity penalty for negative densities, is utilized. The problem is formulated for nonlinear
Phantoms simultaneously mimicking anatomical and optical properties of real tissues can play a pivotal role for improving dosimetry algorithms. The aim of the paper is to design and develop a hybrid phantom model that builds up on the strengths of solid and liquid phantoms for mimicking various anatomical structures for prostate cancer photodynamic therapy (PDT) dosimetry validation. The model com
A selective [4 + 2] cycloaddition reaction of thiazolo-2-pyridones with arynes has been demonstrated. The developed protocol allows rapid access to highly functionalized, structurally complex thiazolo-fused bridged isoquinolones in high yields, which are susceptible to further late-stage functionalization.
Background: Antibody-based immunoassays have enabled quantification of very low concentrations of phosphorylated tau (p-tau) protein forms in cerebrospinal fluid (CSF), aiding in the diagnosis of AD. Mass spectrometry enables absolute quantification of multiple p-tau variants within a single run. The goal of this study was to compare the performance of mass spectrometry assessments of p-tau181, p-
Achaete-scute family bHLH transcription factor 1 (ASCL1) is a master transcription factor involved in neuroendocrine differentiation. ASCL1 is expressed in approximately 10% of lung adenocarcinomas (LUAD) and exerts tumor-promoting effects. Here, we explored miRNA profiles in ASCL1-positive LUADs and identified several miRNAs closely associated with ASCL1 expression, including miR-375, miR-95–3p/m
We propose a Lagrangian method for simultaneous, volumetric temperature and velocity measurements. As tracer particles for both quantities, we employ encapsulated thermochromic liquid crystals (TLCs). We discuss the challenges arising from color imaging of small particles and present measurements in an equilateral hexagonal-shaped convection cell of height h = 60 mm and distance between the parall
Achieving sustainable development and achieving Agenda 2030 goals requires drastic socio-technical changes, where one of the main challenges is to shift from the dominant linear and transaction-based business logic to a logic of circularity and resource-maximization. In the circular economy era, there are a growing number of actors offering consumers the opportunity to rent products instead of buy
