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Background Brain metastases are a common complication in cancer, particularly in patients with breast cancer, lung cancer, and melanoma, and are associated with poor prognosis. Understanding the spatial organization of tumor and immune cells is critical for uncovering the mechanisms of metastasis. Spatial transcriptomics technologies now allow gene expression profiling while preserving tissue arch
The brand Carhartt WIP has been working with establishing their brand image through social media that includes several collections with famous skate companies and posts including famous skaters from their team. Their clothing consisting of big silhouettes and good quality has been valued by the skate - community. Therefore this essay studies how Carhartt WIP is contributing to identity and what bo
Background: Gender differences in palliative care is an under-researched area, both internationally and in Sweden. A regional pilot study by our research group indicated that men have greater unmet palliative care needs prior to referral. Building on these findings, the aim of this study was to examine gender differences in the quality of care received at the end of life within specialized palliat
This thesis investigates sensorless methods for detecting collisions and added weight in dual motor-driven industrial doors, to enhance safety without additional hardware. The study is grounded in the safety requirements outlined in EN 12453:2017 and conducted in collaboration with ASSA ABLOY. By monitoring deviations in the torque-producing current (IQ) from the motors, the developed methods iden
This master thesis presents the development of a vision-based feedback control system for automating sample placement in a virtual neutron beam emulated using a laser. The thesis was carried out on behalf of the European Spallation Source (ESS) to investigate the feasibility, possibilities and limitations of using a robotic automation system for sample alignment. Due to the radioactive research en
Glioblastoma (GBM) remains one of the most aggressive and treatment-resistant brain tumors, with limited systemic therapeutic options and high recurrence rates. New treatment modalities in oncology, including antibody-drug conjugates and CAR-T cells, target the tumor cell surfaceome. However, despite extensive genomic and transcriptomic profiling, actionable surface antigens for targeted immunothe
Alzheimer’s disease (AD) is characterized by amyloid-β (Aβ) plaque deposition, tau pathology, and neuroinflammation, with genetic variants in the apolipoprotein E (APOE) gene representing the strongest risk factor for late-onset AD. Microglia, the brain’s resident immune cells, are increasingly recognized as central to disease progression through their roles in neuroinflammation and Aβ clearance.
Since the discovery of graphene in 2004, there has been intense and continuous research into the possibilities of creating other 2 dimensional (2D) materials. Since then, much progress has been made, resulting in many new metals, semiconductors, and insulators that can fill any number of roles from transistors to solar cells. In this thesis, I discuss hexagonal beryllium oxide (h-BeO) as a potenti
This study aims to explore how healthcare counselors in adult psychiatry in Region Skåne work with children as next of kin and the limitations and opportunities they experience in implementing a child’s perspective. The study is based on six semi-structured interviews with healthcare counselors. The material was analyzed thematically with an inductive approach. The results indicate that healthcare
The dissertation De argutis imaginibus was presented in 1725, in Uppsala, Sweden, by supervisor Lars Arrhenius and respondent Johannes J. Dalenius. The text contains various ideas regarding emblem studies, and concerns itself with emblems as well as other argutae imagines – “witful images”. This thesis aims to present an overview of the content of the dissertation, and to frame this with a cultura
We observe that, while predicting returns remain difficult and uncertain, volatility exhibit more persistence and predictability due to well-known patterns such as volatility clustering (Mandelbrot, 1967). We test whether short-horizon volatility forecasts can be used to time leverage in a passive index strategy so as to mitigate the growth penalty from volatility drag in leveraged exchange-traded
Pollinators such as Bombus terrestris play a vital role in ecosystem stability and agricultural productivity. Developing methods to estimate key biological traits such as age and weight is crucial for advancing ecological understanding and conservation efforts. In eusocial insects like B. terrestris, age and weight influence behaviour, task allocation, and survivability, but traditional methods fo
Adeno-associated viruses (AAVs) are among the most promising vectors for safe and effective gene delivery in therapeutic applications. However, engineering functional AAV capsids remains a major challenge due to the vast sequence space, unpredictable biological performance, and limited translational success of many variants. Machine learning offers a powerful strategy to address these limitations
This thesis examines if the European Patent Convention (EPC) supports or impedes the patentability of green chemistry innovations in pharmaceuticals.. The research is motivated by the growing urgency to align intellectual property systems with environmental objectives under EU law. Using the doctrinal analysis, it evaluates how the European Patent Office (EPO) interprets the EPC’s core requirement
AIM: We investigate if merged gridded satellite rainfall products (CHIRPS, MSWEP, or SUPER), used with the HYPE hydrological model, can replace limited rain gauge measurements when modelling streamflow in poorly gauged basins. Three research questions frame this aim: (1) How does the HYPE hydrological model perform in a poorly gauged basin? (2) Which rainfall product performs better (CHIRPS, MSWEP
Polyolefins make up the majority of all plastics produced and can be found in a range of applications. Simultaneously, 60% of all plastics are not being recycled, and consequently are accumulating in the environment where it poses serious threats to both the environment, human health, and economies. Current attempts to address the problem have had limited success. An emerging solution is biodegrad
Infective endocarditis (IE) is a severe disease affecting the inner lining of the heart. Its diverse symptoms complicate diagnosis and the current main diagnostic tool is the Duke criteria which classifies suspected cases as definite, possible or rejected IE. A substantial portion of cases falls into the ambiguous “possible” category and there is a need for a more precise diagnostic system. This t
Mindfulness har under de senaste åren blivit allt mer populärt i Sverige. Från att främst ha använts inom psykologin för att hantera stress och ohälsa, har det idag spridit sig till arbetsplatser och blivit en del av olika institutioner. I den här uppsatsen undersöks mindfulness ur ett sociologiskt perspektiv: hur praktiken påverkar människors värderingar, identiteter och föreställningar om sig sjMindfulness has increasingly become a popularized phenomenon in Sweden. From being integrated at workplaces and used for therapeutic purposes in psychology, the phenomenon has been institutionalized. This study is a sociological inquiry on mindfulness-related practices and how it shapes values, identities, and beliefs. Using the lens of Pierre Bourdieu’s relational sociology and the methodology of
ODIN (Optical and Diffraction Imaging with Neutrons) is a general purpose imaging in- strument under construction at the European Spallation Source (ESS). The instrument will provide the scientific community with a wide array of neutron imaging techniques, including neutron tomography. Coupled with an integrated X-ray source, the instrument will feature multi-modal capabilities. The complementary
This thesis investigates the integration of artificial intelligence (AI ) within the Swedish courts, with a particular focus on its compatibility with the rights to privacy and a fair trial as enshrined in the Charter of Fundamental Right of the European Union (CFR). As we entered the third decade of the 21st century, a technological revolution, led by AI is transforming various sectors, including
