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Over the years, with advances in our understanding of soft tissue tumors, availability of an increasing number of diagnostic ancillary tests, and matured biopsy techniques with or without image guidance, needle biopsy investigation of a soft tissue lesion has largely replaced open excisional biopsy as the primary diagnostic tool to establish malignancy and to assess histologic type and grade. Fine
In 1952, plans to convert Lake Sanabria (Zamora) into a reservoir for hydroelectric production sparked a press campaign that reached the front pages of the Spanish national press. At the intersection of environmental and political history, this article examines the controversy surrounding the protection of the lake and its designation as a «Picturesque Site» («Paraje Pintoresco») in 1953, under th
Based on material collected with sweep nets, malaise traps and through rearing, the knowledge of the Swedish Chalcidoidea fauna is enhanced by new data on taxa occurring here, including new information on the biology for some of the species. Taxa reported as new to Sweden include one family (Neodiparidae), one genus (Neodipara Erdös) and 33 species in six families: Encyrtidae: Homalotylus platynas
This chapter describes the different types of non-continent urinary diversions, discusses indications, and summarizes common general and specific complications as well as the issue of quality of life. Non-continent urinary diversions are frequently used for lower urinary tract reconstruction after radical cystectomy. Ileal conduits are the most common form of incontinent diversion, followed by col
A large panorama of lesions is accessible to fine-needle aspiration cytology (FNAC). This chapter focuses on lesions of the salivary glands, as well as tumors of the tongue and oral and nasal cavities. Some unusual lesions of the neck will also be presented. Aspiration cytology of thyroid, parathyroid, and lymph nodes is dealt with in other chapters. When confronted with a mass lesion in the head
Instantaneous wave free ratio (iFR) may be a viable alternative to FFR. iFR is a novel measurement of the hemodynamic relevance of coronary lesions which doesn’t require the use of hyperemic agents.
Activation of the kallikrein-kinin system promotes vascular leakage, inflammation, and neurodegeneration in ischemic stroke. Inhibition of plasma kallikrein (PK) – a key component of the KKS – in the acute phase of ischemic stroke has been reported to reduce thrombosis, inflammation, and damage to the blood-brain barrier. However, the role of PK during the recovery phase after cerebral ischemia is
Despite decades of promising preclinical validation and clinical translation, ischemic stroke still remains as one of the leading causes of death and disability worldwide. Within its complex pathophysiological signatures, thrombosis and inflammation, that is, thromboinflammation, are highly interconnected processes leading to cerebral vessel occlusion, inflammatory responses, and severe neuronal d
Street experiments are proliferating in cities worldwide and have emerged as an approach to transform urban mobility and public space. Previous research attests to the broad spectrum of street experimentation and its variety of stakeholders, aims, methods, and impacts. In this article, we probe this multi‐faceted nature through a study of the landscape of street experimentation as it evolved in on
(1) Background: Patients’ experiences and satisfaction with their treatment are becoming increasingly important in the context of quality assurance, but the measurement of these parameters is accompanied by several disadvantages such as poor cross-country comparability and methodological problems. The aim of this review is to describe and summarize the process of measuring, publishing, and utilizi
Background: Glatiramer acetate (GA) is a well-established treatment option for patients with clinically isolated syndrome and relapsing–remitting multiple sclerosis (MS) with few side effects. The double transgenic mouse model spontaneous opticospinal encephalomyelitis (OSE), based on recombinant myelin oligodendrocyte glycoprotein35-55 reactive T and B cells, mimicks features of chronic inflammat
Neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein-antibody-associated disease (MOGAD) are antibody mediated CNS disorders mostly affecting the optic nerve and spinal cord with potential severe impact on the visual pathway. Here, we investigated inflammation and degeneration of the visual system in a spontaneous encephalomyelitis animal model. We used double-tra
Low-grade superficial connective tumors are a heterogeneous group of benign/reactive, intermediate—locally aggressive and intermediate—rarely metastasizing lesions arising in skin and subcutaneous/superficial soft tissues. The most common targets for fine needle aspiration (FNA) in this group of lesions are schwannomas, desmoids, and “pseudosarcomatous lesions” such as nodular fasciitis. Experienc
Objective: Progressive multiple sclerosis is characterized by chronic inflammation with microglial activation, oxidative stress, accumulation of iron and continuous neurodegeneration with inadequate effectiveness of medications used so far. We now investigated effects of iron on microglia and used the previously identified neuroprotective antipsychotic clozapine in vitro and in chronic experimenta
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune-inflammatory CNS disease affecting spinal cord and optic nerves, mediated by autoantibodies against aquaporin-4 (AQP4) and myelin-oligodendrocyte-glycoprotein (MOG). Effects of those immunoglobulins (Ig) on retina and optic nerve are incompletely understood. We investigated AQP4-IgG and MOG-IgG sera on retina and optic nerve ex vivo a
