Pyrimidines are important nucleic acid precursors which are constantly synthesized, degraded, and rebuilt in the cell. Four degradation pathways, two of which are found in eukaryotes, have been described. One of them, the URC pathway, has been initially discovered in our laboratory in the yeast Lachancea kluyveri. Here, we present the global changes in gene expression in L. kluyveri in response to

Exercise is recommended as first-line treatment of degenerative knee disease. Our hypothesis is that neuromuscular exercise is feasible and at least as effective as tradionally used strength or aerobic training, but aims to more closely target the sensorimotor deficiencies and functional instability associated with the degenerative knee disease than traditionally used training methods.SUMMARY FOR

Metabolomics is a growing research field where new protocols are rapidly developed and new applications discovered. Common applications include biomarker discovery and elucidation of drug metabolism. However, the development of such protocols rarely includes a systematic optimization followed by validation with real samples. Here a GC/MS-based protocol using methoximation followed by silylation wi

The importance of family history of venous thromboembolism (VTE) in cancer patients is unclear. We conducted a nationwide study to determine whether family history of VTE is a risk factor for hospitalized VTE in cancer patients.

Background Coordination of breathing and swallowing is essential for airway protection and dyscoordination may cause morbidity and mortality. Methods Using a recently developed technique for high accuracy respiratory measurements of airflow during swallowing, we investigated the effects of body position (upright vs left lateral), bolus type (spontaneously swallowed saliva vs water), and respirator

L-DOPA is the gold-standard treatment for Parkinson's disease (PD), but induces troublesome dyskinesia after prolonged treatment. This is associated with the 'false neurotransmitter' conversion of L-DOPA to dopamine by serotonin neurons projecting from the raphe to the dorsal striatum. Reducing their activity by targeting pre-synaptic 5-HT1A receptors should thus be an attractive therapeutic strat

The historical role of European farming in southern and central Africa has received a great deal of attention among scholars over the years. Going through this vast literature, a striking consensus emerges: the success or failure of European farming in southern Africa was to a large extent dependent upon the colonisers’ access to and control over cheap labour, which they in turn could only access

To detect minute roughness, we utilized the phase change that occurs in a radio frequency echo from the rough surface of an object during its lateral motion. The new method was optimized and validated using saw-tooth-shaped silicone phantoms sized from 13 to 33 mu m; results were compared to those obtained using a confocal laser scanning microscope.

Controlling the stability of anisotropic particles is key to the development of advanced materials. Here, we report an investigation, by means of mesoscale molecular dynamics simulations, of the stability and structural change of calcium-rich dispersions containing negatively charged nanoplatelets, neutralized by calcium counterions, in the presence of either comb copolymers composed of anionic ba

Objective: Development of biomarkers for early detection of Alzheimer's disease (AD) is a major clinical research goal. On the basis of the hypothesis that cardiovascular risk factors contribute to the pathogenesis of AD, we investigated whether the cardiovascular risk markers midregional proadrenomedullin (MR-proADM) and midregional proatrial natriuretic peptide (MR-proANP) predict a major clinic

Aqueous dispersions of Ca montmorillonite contain small clusters of clay platelets, often named "tactoids". In these tactoids, the platelets are arranged parallel to each other with a constant spacing of 1 nm. We have used small-angle X-ray scattering (SAXS) to determine the average number of platelets per tactoid, < N >. We found that this number depends on the platelet size, with larger platelet

All ethnic groups have norms and values according to which one is expected to behave. Immigrants in particular have personal networks that simultaneously consist of co-ethnics and friends of a different ethnic background. As a consequence, they may be accustomed to the behavior, norms, and values of their own ethnic group, and also be expected to behave according to those of another ethnic group.

Stereoisomers of 4-methyl-3-heptanol (MH) are pheromone components of several Scolytus bark beetles. The elm bark beetle Scolytus laevis (Coleoptera: Scolytidae) has in previous studies been caught in traps baited with commercial MH containing all four stereoisomers, but the lure has been considered a weak attractant. In this study, we addressed the question whether stereospecific responses by S.

A differential absorption lidar (DIAL) system based on a Nd:YAG laser pumped narrow-band dye laser is developed and employed to monitor the atmospheric background concentration of atomic mercury in Guangzhou, South China. Atmospheric oxygen is also studied by using neighboring wavelengths to the mercury absorption line (253.7 nm), and is used to verify the operation of the DIAL system. A 24-hour c

Glycosaminoglycans contain a beta-D-xylopyranose residue at its reducing end, which links the polysaccharide to the protein in proteoglycans. 2-Naphthyl beta-D-xylopyranosides have shown inhibition of tumor growth and we herein investigate conformation and dynamics of compounds structurally and stereochemically modified at the C3 position as well as the influence of solvent. The 3-deoxygenated com

The general factor of personality (GFP) is understood as a hierarchically superordinate factor, which suggests that it and the subordinate personality traits are mutually dependent on one another. If a personality inventory captures the subordinate traits the GFP should appear too. Likewise, manipulating the GFP should affect the subordinate traits and vice versa. The current study was an attempt

Purpose – The purpose of this paper is to contribute to the on-going cultural turn in retail marketing by offering an overview of the interdisciplinary field of socio-cultural retailing and discussing how this body of work can contribute conceptually, methodologically and substantively to the field of retail marketing.Design/methodology/approach – This paper is based on a literature review of soci

Here, we describe a novel monoolein-based cubosome formulation engineered for possible theranostic applications in oncology. The Docetaxel-loaded nanoparticles were stabilized in water by a mixture of commercial Pluronic (poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer) F108 (PF108) and rhodamine- and folate-conjugated PF108 so that the nanoparticles possess targ