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The last few decades have witnessed a fundamental change in the administrative law structures of many states. Through the phenomena labelled globalisation, internationalisation and Europeanisation, the national public bodies have seen partially new legal frameworks for administrative activities, judicial review of decisions and accountability regimes. This is very clear in regard to administrative

Pure hydrocarbons with shape and conjugation properties that can be switched by external stimuli is an intriguing prospect in the design of new responsive materials and single-molecule electronics. Here, we develop an oligomeric [8]annulene-based material that combines a remarkably efficient topological switching upon redox changes with structural simplicity, stability, and straightforward synthes

We have measured the 3d→2p transition x rays of kaonic 3He and 4He atoms using superconducting transition-edge-sensor microcalorimeters with an energy resolution better than 6 eV (FWHM). We determined the energies to be 6224.5±0.4(stat)±0.2(syst) eV and 6463.7±0.3(stat)±0.1(syst) eV, and widths to be 2.5±1.0(stat)±0.4(syst) eV and 1.0±0.6(stat)±0.3(stat) eV, for kaonic 3He and 4He, respectively.

We conduct the first 3D hydrodynamic simulations of oxygen-neon white dwarf-neutron star/black hole mergers (ONe WD-NS/BH mergers). Such mergers constitute a significant fraction, and may even dominate, the inspiral rates of all WD-NS binaries. We post-process our simulations to obtain the nuclear evolution of these systems and couple the results to a supernova spectral synthesis code to obtain th

We model the effects of collisions and close encounters on the stellar populations observed in the Milky Way nuclearstellar cluster (NSC). Our analysis is based on N -body simulations in which the NSC forms by accretion of massivestellar clusters around a supermassive black hole. We attach stellar populations to our N -body particles and follow theevolution of their stars, and the rate of collisio

We investigate the possibility that the Sun could have been born in M67 by carrying out N-body simulations of M67-like clusters in a time-varying Galactic environment, and following the Galactic orbits of stars that escape from them. We find that model clusters that occupy similar orbits to M67 today can be divided up into three groups, which we call hot, depleted, and scattered clusters. Hot clus

We present positivity bounds, derived from the principles of analyticity, unitarity and crossing symmetry, that constrain the low-energy constants of chiral perturbation theory. Bounds are produced for 2, 3 or more flavours in meson-meson scattering with equal meson masses, up to and including next-to-next-to-leading order (NNLO), using the second and higher derivatives of the amplitude. We enhanc

Inspired by the flow description of su(N) colour calculations, we recently showed how to simplify the spinor-helicity formalism (at the algebra level two copies of complexified su(2)) by treating each Weyl spinor as part of a flow line with definite chirality and momentum. This formalism, dubbed the chirality-flow formalism, eliminates all non-trivial algebra from tree-level spinor-helicity calcul

Encapsulating reacting biological or chemical samples in microfluidic droplets has the great advantage over single-phase flows of providing separate reaction compartments. These compartments can be filled in a combinatoric way and prevent the sample from adsorbing to the channel walls. In recent years, small-angle X-ray scattering (SAXS) in combination with microfluidics has evolved as a nanoscale

Understanding how environmental variation influences even cryptic traits is important to clarify the roles of selection and developmental constraints in past evolutionary divergence and to predict future adaptation under environmental change. Female yellow dung flies (Scathophaga stercoraria) typically have three sperm storage compartments (3S), but occasionally four (4S). More spermathecae are th

In Alzheimer's disease, post-mortem studies have shown that the first cortical site where neurofibrillary tangles appear is the transentorhinal region, a subregion within the medial temporal lobe that largely overlaps with Brodmann area 35, and the entorhinal cortex. Here we used tau-PET imaging to investigate the sequence of tau pathology progression within the human medial temporal lobe and acro

Tau protein neurofibrillary tangles are closely linked to neuronal/synaptic loss and cognitive decline in Alzheimer's disease and related dementias. Our knowledge of the pattern of neurofibrillary tangle progression in the human brain, critical to the development of imaging biomarkers and interpretation of in vivo imaging studies in Alzheimer's disease, is based on conventional two-dimensional his

Background: Knowledge on tuberculosis (TB) infection epidemiology in women of reproductive age living in TB-endemic areas is limited. We used a composite definition of TB infection in a cohort of pregnant women recruited in an Ethiopian city as a model for TB exposure patterns, and to identify factors associated with TB infection. Methods: Women seeking antenatal care at public health facilities u

Background. Renal biopsies are essential in nephrology but they are invasive and complications can occur. The aim of this study was to explore clinical parameters that can be used as predictors for biopsy complications. Methods. Clinical parameters such as demographics, biopsy indications, serology, comorbidities and clinical chemistry were retrieved from a regional biopsy registry between 2006 an

Billions of specimens can be found in natural history museum collections around the world, holding potential molecular secrets to be unveiled. Among them are intriguing specimens of rare families of moths that, while represented in morphology-based works, are only beginning to be included in genomic studies: Pseudobistonidae, Sematuridae, and Epicopeiidae. These three families are part of the supe

BackgroundThe etiology of male breast cancer (MBC) is poorly understood. In particular, the extent to which the genetic basis of MBC differs from female breast cancer (FBC) is unknown. A previous genome-wide association study of MBC identified 2 predisposition loci for the disease, both of which were also associated with risk of FBC.MethodsWe performed genome-wide single nucleotide polymorphism ge

Intron splicing is an essential event in post-transcriptional RNA processing in plant mitochondria, which requires the participation of diverse nuclear-encoded splicing factors. However, it is presently unclear how these proteins cooperatively take part in the splicing of specific introns. In this study, we characterized a nuclear-encoded mitochondrial P-type pentatricopeptide repeat (PPR) protein