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Spark ablation: The future of nanoparticle generation?
Five propositions on how to combine threat and opportunity management in practice to further develop the project
Risk management in project contexts is increasingly more infocus amongst researchers and practitioners, including the debate on ifand how opportunities can be integrated into the work with threats, or ifseparation is better. In this conceptual paper, integratingseveral strands of literature including risk management, projectmanagement, and organization theory in terms of sensemaking andparadox per
Organizational tensions when managing interorganizational projects : Applying a paradox perspective on large construction projects in Sweden
Over the years, technological developments and societal changes have forced companies to modify their organizing practices. Companies operating in the construction sector are no exception, but due to their project-based structure, it is more difficult to coordinate change initiatives. Indeed, the construction sector is often described as conservative and unwilling to adopt change. However, there i
The adaptive immune response against Streptococcus pneumoniae and epidemiology in Sweden and Angola
Temporariness of Refugee Protection: For What and in Whose Interest? Cessation of Status as Related to Revocation of Residence Permits
Temporariness of refugee protection has started to emerge as a new standard in the policies of European countries. Given this development, the article focuses on one specific issue related to this temporariness: how refugee status intertwines with the conditions for the granting, revocation and prolongation of national residence permits. What are the interconnections between refugee status, includ
Measuring, comparing and interpreting phenotypic selection on floral scent
Natural selection on floral scent composition is a key element of the hypothesis that pollinators and other floral visitors drive scent evolution. The measure of such selection is complicated by the high-dimensional nature of floral scent data and uncertainty about the cognitive processes involved in scent-mediated communication. We use dimension reduction through reduced-rank regression to jointl
Degrowth
This chapter is devoted to introducing degrowth to anyone interested in environmental politics and making connections between the two areas. It articulates critiques of growth, alternatives associated with degrowth and the politics of pursuing them. It is argued that economic growth, with GDP being its key indicator, comes with environmental degradation and is rooted in injustices. Degrowth schola
The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α
Type 1 diabetes (T1D) is an autoimmune disease that results in the destruction of insulin producing pancreatic β-cells. One of the genes associated with T1D is TYK2, which encodes a Janus kinase with critical roles in type-Ι interferon (IFN-Ι) mediated intracellular signalling. To study the role of TYK2 in β-cell development and response to IFNα, we generated TYK2 knockout human iPSCs and directed
Framework for Assessing the Feasibility of Carbon Dioxide Removal Options Within the National Context of Germany
Removal of carbon dioxide from the atmosphere will be required over the next decades to achieve the Paris Agreement goal of limiting global warming to well below 2°C aiming at not exceeding 1.5°C. Technological and ecosystem-based options are considered for generating negative emissions through carbon dioxide removal (CDR) and several nations have already included these in their Long-Term Low Gree
Molecular dynamics simulations of the adsorption of an intrinsically disordered protein: Force field and water model evaluation in comparison with experiments
This study investigates possible structural changes of an intrinsically disordered protein (IDP) when it adsorbs to a solid surface. Experiments on IDPs primarily result in ensemble averages due to their high dynamics. Therefore, molecular dynamics (MD) simulations are crucial for obtaining more detailed information on the atomistic and molecular levels. An evaluation of seven different force f
From dilute to concentrated solutions of intrinsically disordered proteins: Sample preparation and data collection
It is well-known that an increasing proportion of proteins, protein regions, and partners of globular proteins are being recognized as having an intrinsic disorder, and therefore, not adopting a single three-dimensional structure in solution. For these proteins, small-angle X-ray scattering (SAXS) has become a premier method for examination, since it can provide information about the ensemble of t
Molecular dynamics simulations and solid-state nuclear magnetic resonance spectroscopy measurements of C–H bond order parameters and effective correlation times in a POPC-GM3 bilayer
Glycolipids such as gangliosides affect the properties of lipid membranes and in extension the interactions between membranes and other biomolecules like proteins. To better understand how the properties of individual lipid molecules can contribute to shape the functional aspects of a membrane, the spatial restriction and dynamics of C–H bond segments can be measured using nuclear magnetic re
Autoantibodies against red blood cell antigens are common in a Malaria endemic area
Plasmodium falciparum malaria can cause severe anemia. Even after treatment, hematocrit can decrease. The role of autoantibodies against erythrocytes is not clearly elucidated and how common they are, or what they are directed against, is still largely unknown. We have investigated antibodies against erythrocytes in healthy adult men living in a highly malaria endemic area in Uganda. We found anti
A new missense variant in exon 7 of the ABO gene, c.662G>A, in a family with B w phenotype.
1 BACKGROUNDWeak expression of ABO antigens is encountered in the clinical laboratory occasionally, and subgroups of A are more commonly observed in Europeans than subgroups of B. To date, weakly expressing B variant phenotypes have been associated with 38 different alleles according to ISBT (https://www.isbtweb.org/resource/001aboalleles.html). This number is an underrepresentation since there ha
International Society of Blood Transfusion Working Party on Red Cell Immunogenetics and Blood Group Terminology Report of Basel and three virtual business meetings : Update on blood group systems
BACKGROUND AND OBJECTIVES: Under the ISBT, the Working Party (WP) for Red Cell Immunogenetics and Blood Group Terminology is charged with ratifying blood group systems, antigens and alleles. This report presents the outcomes from four WP business meetings, one located in Basel in 2019 and three held as virtual meetings during the COVID-19 pandemic in 2020 and 2021.MATERIALS AND METHODS: As in prev
Migration, transient bodies, and re-construction of the self : embodying refinement of bodies in the borderland of community and society
Migration includes re-starting and re-building a life course. It begins with re-imagination of the journey and the kind of life that is going to take shape in the receiving society. One steps in a migratory journey with knowledge of the past experiences of dealing with risks through, among others, developing an understanding about one’s body. With migration, bodies get displaced, emplaced, replace
Gait and balance among people with de novo vs. mild to moderate Parkinson’s disease
We have investigated how a de novo cohort of people with Parkinson’s disease (PD) differs in terms of balance and gait function as well as frequency of near falls and falls in comparison to a cohort with mild to moderate PD that has been medicated for several years. Preliminary results (Table 1) showed that people with de novo PD have balance and gait impairments and that some have also experience
Non-career firefighters in rural areas - Exploring aspects contributing to retention
Det övergripande syftet med denna licentiatavhandling är att öka kunskapen kring vad som påverkar att jobba som en brandman vars huvudsakliga sysselsättning är utanför räddningstjänsten (exempelvis frivilliga brandmän eller deltidsbrandmän) för att förstå hur utmaningar och engagemang påverkar beslutet att fortsätta vara verksam. Bibehållandet av dessa brandmän är en välkänd utmaning i många ländeThe overarching aim of this licentiate thesis is to increase knowledge about the implications of working as a non-career firefighter in order to understand how challenges and commitment affect retention. Retention of non-career firefighters (for example volunteer or part-time firefighters) is a well-known, multifaceted challenge in several countries. These non-career firefighters account for the m