To steer the economy towards a low-carbon future and mitigate climate change, the European Union Emissions Trading System (EU ETS) has been established at the European level. It operates through a cap-and-trade mechanism and currently regulates around 40% of the EU’s CO2 emissions. However, due to regional differences in the industry mix and the spatial concentration of regulated industrial instal

How do the limits of high-level visual processing affect human performance in naturalistic, dynamic settings of (multimodal) interaction where observers can draw on experience to strategically adapt attention to familiar forms of complexity? In this backdrop, we investigate change detection in a driving context to study attentional allocation aimed at overcoming environmental complexity and tempor

Herein, the first example of a homoleptic AgIII complex stabilized by a monodentate N-donor ligand is presented. Na2[S2O8] oxidizes the linear AgI complex, Na[Ag(succ)2] (1Na), to form a square planar argentate(III) ion, [Ag(succ)4]–, which crystallizes with a polymeric chain-structure, M[Ag(succ)4] (2M), when treated with alkali metal sulfate M2SO4 (M = K, Rb, Cs). A mixed-valent Robin-Day class

The first authoritative overview of tourism studies published post-COVID-19 The Wiley Blackwell Companion to Tourism remains a definitive reference in this interdisciplinary field. Edited and authored by leading scholars from around the world, this state-of-the-art volume provides a comprehensive critical overview of tourism studies across the social sciences. In-depth yet accessible chapters comb

We develop a cognitive evaluation schema for analysing the diversity and nuances of visuospatial complexity and multimodal interactions encountered in naturalistic everyday driving conditions. The proposed schema is based on a finegrained empirical analysis of real-world everyday driving situations involving stakeholders such as drivers, pedestrians, cyclists. Our method involves a semantic analys

Obesity is a risk factor for cardio-metabolic and neurological disease. The contribution of gut microbiota to derangements of the gut-brain axis in the context of obesity has been acknowledged, particularly through physiology modulation by short-chain fatty acids (SCFAs). Thus, probiotic interventions and administration of SCFAs have been employed with the purpose of alleviating symptoms in both m

Blood-based biomarkers (BBM) for Alzheimer's disease (AD) are being increasingly used in clinical practice to support an AD diagnosis. In contrast to traditional diagnostic modalities, such as amyloid positron emission tomography and cerebrospinal fluid biomarkers, BBMs offer a more accessible and lower cost alternative for AD biomarker testing. Their unique scalability addresses the anticipated s

The evidence-based analysis of people's navigation and wayfinding behaviour in large-scale built-up environments (e.g., hospitals, airports) encompasses the measurement and qualitative analysis of a range of aspects including people's visual perception in new and familiar surroundings, their decision-making procedures and intentions, the affordances of the environment itself, etc. In our research

Parametric design systems serve as powerful assistive tools in the design process by providing a flexible approach for the generation of a vast number of design alternatives. However, contemporary parametric design systems focus primarily on low-level engineering and structural forms, without an explicit means to also take into account high-level, cognitively motivated people-centred design goals.

Evidence-based design (EBD) for architecture involves the study of post-occupancy behaviour of building users with the aim to provide an empirical basis for improving building performance [Hamilton and Watkins 2009]. Within EBD, the high-level, qualitative analysis of the embodied visuo-locomotive experience of representative groups of building users (e.g., children, senior citizens, individuals f

Copper complexes supported by benzimidazole-based tetradentate neutral ligands featuring thio- and selenoether donors, resemble the coordination environment of the active site in copper dependent monooxygenases Dopamine-β-monooxygenase (DβM) and peptidylglycine-α-hydroxylating monooxygenase (PHM). The cuprous complexes react with O2 at low temperature generating a reactive copper-oxygen species as

Changing rainfall patterns make farmers increasingly vulnerable to crop failure, income loss and food insecurity. Agroecology is proposed to reduce climate vulnerabilities of farmers, as such practices and social movement aim to create more resilient farm and food systems. It is however fairly unknown if, and to what extent, agroecological farmers are better able to cope with climate induced expos

The physical layer foundations of cell-free massive MIMO (CF-mMIMO) have been well-established. As a next step, researchers are investigating practical and energy-efficient network implementations. This paper focuses on multiple sets of access points (APs) where user equipments (UEs) are served in each set, termed a federation, without inter-federation interference. The combination of federations

Aims: Superficial CD34-positive fibroblastic tumour (SCD34FT) is an uncommon but distinctive low-grade neoplasm of the skin and subcutis that shows frequent CADM3 expression by immunohistochemistry (IHC). In this study, prompted by an index case resembling ‘atypical fibrous histiocytoma (FH)’ that was positive for CADM3 IHC, we systematically examined a cohort of tumours previously diagnosed as ‘a

INTRODUCTION: Unraveling how Alzheimer's disease (AD) genetic risk is related to neuropathological heterogeneity, and whether this occurs through specific biological pathways, is a key step toward precision medicine. METHODS: We computed pathway-specific genetic risk scores (GRSs) in non-demented individuals and investigated how AD risk variants predict cerebrospinal fluid (CSF) and imaging biomar

A novel flamelet-generated manifold (FGM) model is introduced, encompassing ignition and flame propagation in ammonia/n-heptane dual-fuel combustion under reactivity-controlled compression ignition (RCCI) engine conditions. To generate the FGM mapping function (FGM tabulation) accounting for multiple combustion modes in RCCI combustion, a novel one-dimensional RCCI configuration (1D-RC) is propose

Introduction: Digital options for osteoarthritis (OA) treatment are increasingly available with high patient satisfaction and acceptability. Little is, however, known about physical therapists’ (PT) perception of this treatment modality. Objective: To investigate PT’s experience of delivering digital treatment for hip and knee OA using a smart-phone application. Method: Nine PTs (mean age 36 years

B lymphopoiesis is orchestrated by lineage-specific transcription factors. In B cell progenitors, lineage commitment is mediated by Pax5, which is commonly mutated in B cell acute lymphoblastic leukemia. Despite its essential role in immunity, the mechanisms regulating Pax5 function remain largely unknown. Here, we found that the NAD+-dependent enzyme SIRT7 coordinates B cell development through d