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Targeting neuroinflammation, a key factor in the progression of chronic neurological disorders such as Alzheimer’s disease and epilepsy, is essential for discovering effective treatments. Recent studies indicate that Pannexin-1 (Panx-1) channels serve as the primary pathways for ATP release from degenerating and innate immune cells in the brain, triggering neuroinflammation. By blocking it with a
As electricity distribution companies face growing volumes of operational data, strategic data management becomes increasingly important. This thesis investigates how E.ON Sverige, a Swedish electricity distribution company, can manage its growing data volumes more efficiently and sustainably, both financially and environmentally. The study explores the regulatory requirements and internal stakeho
In a society facing rising sea levels and the associated challenges, such as flooding, there is a growing need for climate adaptation measures. This thesis aims to examine climate adaptation efforts in the region of Skåne, Sweden, by exploring the role of insurance companies – an important stakeholder in the housing market as insurance is a requirement for most bank loans – in urban planning. Addi
I mötet med sångimprovisation i en rytmikkontext under vår utbildning på Musikhögskolan i Malmö väcktes ett intresse att titta på vilka förutsättningar som kan främja framtida elevers sångimprovisation. Syftet med studien är att undersöka hur sånglärare på gymnasie- och folkhögskolenivå ser på begreppet improvisation, hur de skapar förutsättningar för elever att improvisera samt hur rytmik som för
This paper expands on the literature on labor market power and its impact on wages. With previous studies having focused on labor market concentration, this paper reviews theoretical background for firm heterogeneity and argues firm size inequality (FSI) presents an alternative theoretical framework through which labor market power can be evaluated. The paper then quantitatively estimates the impa
In the context of reducing aviation emissions, understanding flame dynamics and improving combustion efficiency are key factors in the development of low-emission engines. Computational Fluid Dynamics (CFD), and in particular Large Eddy Simulation (LES), are powerful tools to investigate unsteady phenomena such as blow-off of turbulent flames. Understanding flame stabilization and extinction pheno
Test Case Prioritization and Selection (TCPS) methods aim to order or select tests to minimize test execution time without significantly reducing test coverage. In collaboration with a System Analysis Team at Arm, this project demonstrated machine learning-driven prioritization in an industrial Continuous Integration (CI) pipeline, using predictive models to optimize test execution. The team runs
Tail risk metrics such as VaR and, especially ES are and have become of great importance to both investors and financial institutions such as banks in determining their amount of loss absorbing capital given the Basel framework. Estimating these metrics have become trivial, but to do it accurately while also taking market conditions such as periods of market stress into account still presents chal
Detta examensarbete presenterar utvecklingen av en ny generation mekanisk nyckelbrytare (KS) för impulsgivning i passersystem. Projektets fokus låg på att förbättra manipuleringståligheten hos hårdvara som exponeras för krävande miljöer, såsom utomhusinstallationer, samtidigt som stöd för flera vanliga cylindertyper integrerades, inklusive Euro DIN, Kaba och ASSA-cylindrar. Att stärka den fysiskaThis master's thesis presents the development of a new generation mechanical key switch (KS) used for key-impulse activation in access systems. The project's focus has been to enhance tamper resistance in hardware exposed to demanding environments, such as outdoor installations, while introducing support for multiple common lock cylinder formats, including Euro DIN, Kaba, and ASSA cylinder
Modernity is reflected in various sectors, with education being one of the most prominent. New expectations have emerged, and a ‘juridification’ of schooling has increased the pressure on teachers by assigning them new responsibilities that were traditionally managed by other authorities. Despite a legislative shift in the Swedish Educational Act in 2010, there remains a lack of clarity regarding
This thesis investigates the mid-term employment effects of the 2018 U.S. tariff escalation under the first Trump administration. While the tariffs were introduced to protect domestic industries and “bring back jobs,” their actual labor market impacts remain uncertain. While previous research focuses on short-term effects or isolated industries, this thesis takes a broader perspective by examining
Molecular pathologies can be targeted using lipid nanoparticles carrying therapeutic RNA. Extrahepatic delivery remains a major bottleneck, however, small lipid nanoparticles could allow targeting of deeper tissue layers, low vascularized tumors and the lymph nodes, improving the range of druggable cell types and diseases. Lipid nanoparticle size as a tunable parameter influencing therapeutic effi
This thesis examines the interaction between capital markets, commercial banks, and investment banks, by further developing an existing model of financial system architecture. The development consists of adding the distinction between commercial and investment banks to the bank sector. Previous literature has debated whether the development of the bank sector and capital markets is mutually benefi
This thesis examines which fiscal instruments are considered as Covered Taxes under the GloBE Model Rules particularly in the Oil and Gas sector. The countries used for the examination are Brazil and Nigeria as both have a huge oil and gas sector. While Brazil has adopted a Qualified Domestic Top-up Tax, Nigeria has abstained against the Pillar Two framework. The main research question explor
This thesis aims at understanding, through simulation, how the cosmic muon flux will look like in LDMX’s HCal and to use the characteristics of minimally ionizing muons to set up a method for scintillator bar calibration. LDMX’s HCal is a sampling calorimeter with scintillator bars as the active material. Cosmic muons enter the HCal from different angles, and thereby deposit different amounts of e
This paper addresses sustainability clauses in the European Union’s (EU) free trade agreements (FTAs) and examines their role in integrating environmental, social, and economic objectives within international trade. Against the backdrop of global sustainability agendas – namely Agenda 2030 and the European Green Deal – the study investigates how these contractual provisions are designed to support
This study presents a comprehensive analysis of the spatiotemporal dynamics of water quality in Lake Bolmen, southern Sweden, based on high-resolution monitoring data (2022–2024) from five regions. Key parameters—including temperature, dissolved oxygen, pH, turbidity, electrical conductivity, oxidation-reduction potential, and chlorophyll fluorescence—were assessed using data analysis method inclu
Choosing the right discrete-event simulation (DES) software is a challenging and important task. Given the announcement that sales and support of AFRY’s primary DES software, AutoMod, will be discontinued by December 31, 2026, and the lack of a recent review of the current market offerings, it is a essential for AFRY to explore new alternatives. The aim of the thesis is to help AFRY analyze and se
This thesis explores the electrification of the public transport sector in Kathmandu Valley using the Multi-Level Perspective framework and a lens based on Political Economy. It analyses how government bodies, the private sector, civil society, development organisations, and academia influence transition dynamics. Drawing on semi-structured interviews and fieldwork, it identifies drivers such as a
Under de senaste decennierna har vårdsystem i allt högre grad formats av styrmodeller inriktade på effektivitet, ofta påverkade av marknadsbaserade ideal. Denna studie undersöker hur sjuksköterskor upplever konsekvenserna av sådana reformer, särskilt i relation till deras arbetsvillkor och deras upplevda kvalitet på patientvården, samt hur dessa upplevelser skiljer sig mellan offentlig och privat
