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This white paper presents a comprehensive biobanking framework developed at the European Cancer Moonshot Lund Center that merges rigorous sample handling, advanced automation, and multi-omic analyses to accelerate precision oncology. Tumor and blood-based workflows, supported by automated fractionation systems and standardized protocols, ensure the collection of high-quality biospecimens suitable
Persistent bacterial airway infection is a hallmark feature of cystic fibrosis (CF). Achromobacter spp. are gram-negative rods that can cause persistent airway infection in people with CF (pwCF), but the knowledge of host immune responses to these bacteria is limited. The aim of this study was to investigate if patients develop antibodies against Achromobacter xylosoxidans, the most common Achr
Memories link elements across event boundaries, integrating overlapping content experienced at different times and places. Such memory representations are thought to rely on memory integration mechanisms. The present study used multivariate pattern analysis (MVPA) of electroencephalographic (EEG) data to elucidate the temporal dynamics of integrative encoding memory processes. Memory integration w
Contextual shifts are crucial for episodic memory, setting event boundaries during event segmentation. While lab research provides insights, it often lacks the complexity of real-world experiences. We addressed this gap by examining perceptual and conceptual boundaries using virtual reality (VR). Participants acted as salespeople, interacting with customers in a VR environment. Spatial boundaries
BackgroundPresence of a prosthetic joint entails a life-long risk of haematogenous periprosthetic joint infection (hPJI) during bacteraemia. For bacteraemia with Staphylococcus aureus the hPJI frequency has been described to be up to 40% and for streptococci up to 20%, with large variation among reported frequencies.ObjectivesWe aimed to investigate the hPJI frequency from bacteraemia with virulen
Objectives: Cystic fibrosis hepato-biliary involvement (CFHBI) is a common comorbidity in patients with CF and is associated with increased morbidity and mortality. The effect of the new and highly potent CF transmembrane conductance regulator modulator therapy, elexacaftor-tezacaftor-ivacaftor (ETI), on CFHBI, is still unclear. This study aimed to investigate the impact of ETI on liver stiffness
Experiments using the surface force apparatus have found anomalously long-range interactions between charged surfaces in concentrated salt solutions. Ion clustering has been suggested as a possible origin of this behavior. In this work, we demonstrate that if such stable clusters indeed form, they are able to induce remarkably strong free energy barriers under conditions where a corresponding solu
In villages and cities across the Indonesian island of Java, hundreds of songbird competitions are held every week. In these competitions, members of one species of songbird compete each other, where the aesthetic qualities the song, including its rhythm, melody, timbre, and volume, are evaluated by a team of referees. First prizes are large cash awards and sometimes cars. Birdsong that incorpora
Serum Amyloid A (SAA) proteins are critical mediators of immune activation and metabolic regulation, bridging the acute-phase response with long-term disease dynamics. Once considered mere biomarkers of inflammation, emerging research has revealed their central role in orchestrating immune responses, lipid metabolism, and tissue remodeling. SAA proteins display context-dependent functions: they pr
Blood coagulation is essential for stopping bleeding but also drives thromboembolic disorders. Factor XII (FXII)-triggered coagulation promotes thrombosis while being dispensable for hemostasis, making it a potential anticoagulant target. However, its physiological role remains unclear. Here, we demonstrate that FXII-driven coagulation enhances innate immunity by trapping pathogens and restricting
»Music to me is… my work. I've landed in the best job in the world, where a core task is to discover new music, to learn its internal logic and aesthetics, who created it, and why. I'm a music researcher and have just returned from the island of Java in Indonesia with my research partner and husband Nils, where we've been visiting experimental musicians in Yogyakarta – artists we've now followed f
Swedish art and music schools (SAMS), established in the 1940s, aim to provide affordable extra-curricular instrumental and singing education for all children, regardless of their parents’ economic situation. The tuition is highly subsidized, with families contributing only about 7% of the tuition costs. While traditionally focusing on one-to-one instruction, a recent governmental report (2016) ha
In the present work, we describe the design, synthesis, and evaluation of a galectin-8- binding fluorescent probe designed for a competitive fluorescence polarization (FP) assay for screening new galectin-8N inhibitors. The probe was characterized for its photophysical properties and its binding affinity for galectin-8N was determined by using FP. We evaluated the probe in a competitive FP assay w
Interview with Swedish jazz pianist Jan Lundgren on storytelling in jazz improvisation.
This guide will give you an introduction to the history of the Cuneiform Digital Library Initiative (CDLI) and a basic overview of the CDLI research platform and data collections. It will enable you to conduct simple and advanced searches of the hundreds of thousands of artifacts in the database, filter and download your search results, register a user account with CDLI in order to edit and contri
Background: The existence of a “minority tax,” defined as the burden of extra responsibilities placed on minorities relative to non-minorities of the same position, has been documented across various fields, including and beyond medicine. This study sought to quantify the types and extent of the minority tax faced by minority orthopaedic surgeons, as well as evaluate the degree to which this work
Industrial and urban symbiosis (IUS) is an emerging sustainability strategy in which organizations collaborate to optimize resource flows and minimize waste within urban environments. Rooted in circular economy principles, IUS has gained global attention as cities seek innovative solutions to enhance resource efficiency and resilience. However, local authorities play a critical yet underexplored r
