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Background: In breast cancer, several gene expression assays have been developed to provide a more personalised treatment. This study focuses on the prediction of two molecular proliferation signatures: an 11-gene proliferation score and the MKI67 proliferation marker gene. The aim was to assess whether these could be predicted from digital whole slide images (WSIs) using deep learning models. Met

Infants at elevated likelihood for or later diagnosed with autism typically have smaller vocabularies than their peers, as shown by the Mullen Scales of Early Learning (MSEL) and the MacArthur-Bates Communicative Developmental Inventory (CDI). However, the extent to which MSEL and CDI scores align remains unclear, especially across clinical and non-clinical populations. This study examined whether

Bioresorbable photonic implants are emerging as potential material choice for interstitial theranostic and monitoring applications. They gradually dissolve within the physiological environment in a clinically relevant period, eliminating the need for extraction surgeries. In the present study, we tested the suitability of in-house fabricated bioresorbable optical fibres based on calcium phosphate

With the current state of knowledge regarding disorders of facial bone development, including anodontia, the development of a suitable animal model for preclinical studies is essential. The agenesis of dental buds occurs in about 25% of the human population. Prospects for treatment include the use of growth factors, stem cells, and bioengineering. This study aimed to investigate the influence of a

Background: The objective of this paper was to estimate the impact of country-wide hospital pay-for-performance on readmissions for a set of common conditions in Lebanon. Methods: This retrospective cohort study included all hospitalizations under the coverage of the Ministry of Public Health in Lebanon between 2011 and 2019. We calculated 30-day all-cause readmissions following general, pneumonia

In this paper we propose minimal solvers for relative pose estimation for two views of the projected silhouettes of two 3D cylinders. Using such line features instead of the standard point feature correspondences means more stable information (i.e. more stable to lighting condition, seasons, changes in environment etc.). Such features also lead to more compact and semantically interpretable repres

Time delay estimation or Time-Difference-Of-Arrival estimates is a critical component for multiple localization applications such as multilateration, direction of arrival, and self-calibration. The task is to estimate the time difference between a signal arriving at two different sensors. For the audio sensor modality, most current systems are based on classical methods such as the Generalized Cro

This paper suggests an approach to solving the time-of-arrival self-calibration problem for imbalanced problems, where there is a low number of receivers but many senders. The idea is to solve several subproblems created by only using data relating to four receivers. The solutions are then clustered according to a proposed metric in order to remove failed reconstructions. They are then combined in

IMPORTANCE During the past decade, spinal surgical procedures have been increasingly performed on an ambulatory basis, a change in clinical practice supported only by observational evidence thus far. There have been no randomized clinical trials (RCTs) comparing ambulatory care with inpatient care after any spinal surgery. OBJECTIVE To assess whether ambulatory care is noninferior to overnight hos

Appropriate time discretization is crucial for real-time applications of numerical optimal control, such as nonlinear model predictive control. However, if the discretization error strongly depends on the applied control input, meeting accuracy and sampling time requirements simultaneously can be challenging using classical discretization methods. In particular, neither fixed-grid nor adaptive-gri

Rieger syndrome is an autosomal dominant human disorder affecting eye, tooth and umbilical development, andwhose primary morbidity is the 50% occurrence of glaucoma in affected individuals. The identification of etiologicmutations in the PITX2 gene and its encoded protein, solurshin, inspired the development of a transgenic animal thatmight serve as a model for this disorder. In addition, the more

Att ställa om från fossila bränslen inom sjöfartssektorn kommer att bli ännu svårare än att vända en oljetanker. Det övergripande syftet med denna avhandling, som är förankrad i sustainability transitions-litteraturen, är att öka den nuvarande förståelsen för hur multiskalära uppifrån-och-ner- samt nerifrån-och-upp-processer påverkar sociotekniska förändringar som bidrar till minskade koldioxidutsShifting away from fossil fuels in the maritime shipping sector promises to be even more difficult than turning an oil tanker. Anchored in the sustainability transitions literature, the overall aim of this thesis is to advance the current understanding of how multi-scalar top-down and bottom-up processes influence socio-technical change towards decarbonisation of the global maritime shipping secto

Trichomoniasis is a sexually transmitted infection (STI) caused by the microphilic parasitic protist Trichomonas vaginalis. The common sign and symptoms of the infection are vaginitis, cervicitis, dysuria, urethritis, vaginal discharge with foul smell, pelvic inflammatory disease (PID), dyspareunia, preterm delivery, and low birth weight. It plays a vital role in the transmission and acquisition o

Since the normalization of Sino-Korean diplomatic relations in 1992, many South Koreans have moved to China for business, education, and other purposes. There they have encountered Korean-Chinese; ethnic Koreans who have lived in China for decades. This has lead to 'intra-ethnic conflict' which has divided Korean communities.

This book offers a first look at transnational education corporations, new firms that operate international schools. The quiet rise of transnational education corporations – or TECs – has implications for education systems around the globe, as corporate interests gain a greater stake in the way schools operate. The story of their ascendance links government policies in one corner of the world with

Recent years have seen the emergence of critical studies pro-duced by third- generation Displaced Persons (hereafter DPs),questioning ethno-nationalist historical narrations, hegemonicin the community. Yet, in the Ukrainian diaspora in Canada, suchstudies have been absent. Kassandra Luciuk’s current study iswritten by someone raised in the political elite of the Ukrainianethno-nationalist communit

Th e performance of a mean field th eory (MFT) neu ralnetwork technique for finding approximate solutions to optimi zationproblems is invest igat ed for the case of th e minimum cut graph bisection problem, which is NP- complete. We address the issues of solut ionquality, programming complexity, convergence tim es and scala bility.Both standard random gr aphs an d mor e st ruct ured geomet ric gra