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Immunotherapy has shown limited success in acute myeloid leukemia (AML), indicating an incomplete understanding of the underlying immunoregulatory mechanisms. Here we identify an immune evasion mechanism present in 60% of AML cases, wherein primitive AML cells aberrantly express the lymphoid surface protein SLAMF6 (signaling lymphocyte activation molecule family member 6). Knockout of SLAMF6 in AM
PurposeThe purpose of this study is to empirically explore how contractual learning in public procurement is affected by organizational design.Design/methodology/approachTwo inductive case studies are based on semi-structured interviews and document analysis.FindingsThe author finds that the consolidation of economic, technical and legal tasks in specific units can strengthen contractual learning
Denna avhandling utvecklar och utvärderar språkbaserade bedömningar som använder artificiell intelligens (AI) för att omvandla öppet språk till kvantitativa indikatorer och beskrivningar av psykiska hälsorelaterade konstruktioner. Medan slutna skalor länge har dominerat psykologiska bedömningar, är de begränsade av fasta svarsformat och kanske inte helt fångar komplexiteten i individers upplevelseThis thesis develops and evaluates language-based assessments that use artificial intelligence (AI) to transform open-ended language into quantitative indicators and descriptions of mental health related constructs. While closed-ended scales have long dominated psychological assessment, they are limited by fixed response formats and may not fully capture the complexity of individuals’ experiences.
Large language models can transform individuals’ mental health descriptions into scores that correlate with rating scales approaching theoretical upper limits. However, such analyses have combined word- and text responses with little known about their differences. We develop response formats ranging from closed-ended to open-ended: (a) select words from lists, write (b) descriptive words, (c) phra
Background: Exposure to per- and polyfluoroalkyl substances (PFAS) has been associated with lower bone mineral content (BMC) and density (BMD) in children, but prospective studies remain limited. We aimed to investigate associations between prenatal and childhood PFAS exposure and BMC/BMD at age 9 years, following up on our previous findings from age 7 years. Methods: We used data from the Odense
This chapter calls for policy tools to address gentrification and displacement through one of the most recently discussed and complex lenses of gentrification: green and climate gentrification. Those processes are directly related to residential physical and sociocultural displacement and insecure housing conditions - with demonstrated health impacts - among socially or racially underprivileged re
This chapter delves into the evaluation of national innovation policies through a case study of the Brazilian National Innovation Policy (NIP). Assessing these policies poses several challenges, including the difficulty of defining and measuring policy outcomes, the scarcity of reliable data, and the intricacies of interactions among various stakeholders involved in the policy. Additionally, polit
This study explores how Chilean university students perceive entrepreneurship, exploring whether they see it as an opportunity to address societal challenges or primarily as an enterprise creation. The research focuses on how these perceptions vary by gender in front of sociodemographic, academic, and institutional influential factors. Using a quantitative approach, we collected data from a sample
BackgroundIbrutinib, a Bruton tyrosine kinase inhibitor, prolongs progression-free survival when added to immunochemotherapy as first line treatment. The ENRICH trial compared the chemotherapy-free combination of ibrutinib and the anti-CD20 antibody rituximab (ibrutinib–rituximab) with standard immunochemotherapy (R-CHOP [rituximab–cyclophosphamide, doxorubicin, vincristine, and prednisolone] or b
Due to their high reactivity, organolithium and organomagnesium addition to ketones is usually performed under inert atmosphere at low temperature. Recent work has shown that, by dissolving the substrate in deep eutectic solvents (DES), these processes can be carried out on the benchtop, in air at room temperature. Surprisingly, the organometallic reagent, added to the DES from an organic sol
This paper provides a comprehensive overview of quantile-parameterized distributions (QPDs) as a tool for capturing expert predictions and parametric judgments. We survey a range of methods for constructing distributions that are parameterized by a set of quantile-probability pairs and describe an approach to generalizing them to enhance their tail flexibility. Furthermore, we explore the extensio
This doctoral thesis presents a comprehensive investigation into action-detected two-dimensional electronic spectroscopy (A-2DES), from the technical development of a state-of-the-art apparatus to its application in elucidating ultrafast dynamics in advanced materials and biological systems. The work is founded on the design and implementation of an A-2DES setup centered on a single acousto-optic
The aim of this paper is to examine how various types of investors react, and how ownership structures of firms involved in unethical tax practices change once these unethical behaviours are made public. It combines news data with market data to identify investor reactions to tax scandals. Using a staggered diff-in-diff approach, we find that different ownership classes such as hedge funds, banks,
This essay addresses the urgent need for transformative action in environmental governance by exploring the role and essential functionality of environmental auditing. While critical scholarship has questioned the overemphasis on reporting in both research and practice, this essay promotes the obligation on critical accountants and auditing researchers to actively debate and develop the concept of
BACKGROUND: The incidence of postural orthostatic tachycardia syndrome (POTS) in long COVID has been a growing concern since the first cases were reported in 2021. The aim of this study was to assess the prevalence and clinical impact of POTS in a series of well-characterized patients with long COVID.METHODS: We prospectively analyzed 467 nonhospitalized, highly symptomatic (sick leave ≥50%) patie
