Research shows that a significant portion of the environmental impact from products is determined already in the design phase. Implementation of principles of Circular Economy (CE) in design practice has the potential to reduce waste and to encourage reuse of resources. Since designers are responsible for the design process, it is therefore relevant to investigate whether designers are properly eq

The peer-reviewed version can be found here: https://doi.org/10.1016/j.jenvp.2024.102278Given the increasing severity of the climate crisis and, with it, rising climate anxiety, it is imperative to understand what climate anxiety is, how it functions, and how people can cope with it constructively. Nevertheless, research has often mixed different conceptualizations and operationalizations of clima

Diversification of cropping systems creates multiple benefits for the sustainable development of agroecosystems. Notably, introducing intercrops and cover crops in crop rotations allows ecient use of resources and promotes the synergy between ecosystem processes and functions (e.g. enhancing soil quality, preventing risk of build-up of pests and diseases). We used eld experiments to assess how g

Corporate Social Responsibility is used as an organizational strategy and with this power it has been established that it brings endless advantages, especially in market acceptance and growth of business image. In the country and in the department of Cochabamba, it is undergoing considerable development, growth and evolution, reaching the idea of it being used as a business strategy, to be include

The present study reports the state of the art on the application of factors about prototyping engineering approach, using case studies of machinery manufactured by research centers of the Universidad Mayor de San Simon (UMSS) in Cochabamba-Bo-livia, to determine guidelines that allow structuring broad, analytical and intuitive prototyping strategies. The research centers linked to the case studie

Mixtures between choline and geranic acid (CAGE) have previously been shown to insert into lipid bilayers. This may be useful for the transdermal delivery of larger pharmaceuticals, however, little is known about the mechanism of activity. By comparing the interactions between CAGE and lipid bilayers with those of a less-active, yet closely-related analogue, choline octanoic acid (CAOT), a chemica

The creation of prototypes for the design of new products is a fundamental activity in the metal-mechanic sector that contributes to Bolivia's socioeconomic development. The existence of a multitude of factors that positively or negatively affect the prototype, are encompassed in two approaches: i) prototyping engineering and ii) prototyping management. Research for the design of prototypes suitab

Objective: To test if decreased parental protective behaviors, monitoring behaviors, and parental catastrophizing mediate relief of gastrointestinal symptoms in children 8–12 years with functional abdominal pain disorders (FAPDs). The study uses secondary data analyses of a randomized controlled trial in which exposure-based online cognitive behavioral therapy (ICBT) was found superior to treatmen

Kienböck's disease may result from a wrist-joint tamponade due to a mechanism similar to a compartment syndrome. An early drainage of the joint can probably prevent the necrosis of the lunate bone.

Background: Periodontitis and oral pathogenic bacteria can contribute to the development of rheumatoid arthritis (RA). A connection between serum antibodies to Porphyromonas gingivalis (P. gingivalis) and RA has been established, but data on saliva antibodies to P. gingivalis in RA are lacking. We evaluated antibodies to P. gingivalis in serum and saliva in two Swedish RA studies as well as their

Protein drugs, such as monoclonal antibodies, have proved successful in treating cancer and immune system diseases. The structural complexity of these molecules requires careful handling to ensure integrity and stability of the drug. In this study, a failure mode and effects analysis was performed based on a Gemba Walk method in a Swedish University Hospital. The Gemba Walk is focused on pharmacis

Nature-based solutions is a new trend in the area of urban and suburban planning. Thanks to its complex nature, Nature-based solutions provide multiple services on different levels of cities functionality. On the other hand nature-based solutions complexity requires extended knowledge in multiple engineering and societal areas, so the implementation is not straightforward. In recent years, countle

Non-typeable Haemophilus influenzae (NTHi) is a Gram-negative human pathogen that causes a wide range of airway diseases. NTHi has a plethora of mechanisms to colonize while evading the host immune system for the establishment of infection. We previously showed that the outer membrane protein P5 contributes to bacterial serum resistance by the recruitment of complement regulators. Here, we report

For the past two decades, immunotherapy revolutionized cancer treatment. However, responses vary significantly among eligible patients and some cancer types are not yet open to immunotherapy. Several mechanisms contribute to immunotherapy resistance, including loss of antigen presentation machinery and immunosuppression. Conventional dendritic cells type 1 (cDC1) are a rare population of professio