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Robustness of the voluntary breath-hold approach for the treatment of early stage lung cancer with spot scanned proton therapy

Background: Intra- and interfractional variations in anatomy can cause unplanned substantial alterations of the dose distribution of the target in proton therapy. Motion management methods might be used in order to minimize anatomical variations. In the proton therapy of lung cancer, a potential motion management technique is the use of the voluntary breath-hold approach. The aim of this study was

Evaluation of the breath-hold approach in proton therapy of lung tumors

Proton therapy has the potential to improve the local control rates and reduce the risk of toxicity forlung cancer patients. However, the delivery of proton therapy is prone to uncertainties caused byanatomical changes and motion during the treatment and between the treatment fractions whichmay compromise its effectiveness. The dosimetric uncertainty of lung cancer proton therapy can beminimized t

Identifying Non-Steroidal Anti-Inflammatory Drug (NSAID) Users Among People with Osteoarthritis Through Administrative and Clinician-Reported Data - A Validation Study of 116,162 Patients

PURPOSE: (i) To report the prevalence of participants to a first-line intervention for OA in Sweden using over-the-counter (OTC) and/or prescribed NSAIDs; (ii) To estimate the accuracy of dispensed prescriptions of NSAIDs recorded in a Swedish health-care register to capture the use of NSAID considering clinician-report as reference standard.METHODS: Register-based study. We used data from OA indi

Stance-Conveying Hashtag Functions in Organic Food Tweets : #youneedtoknow

This corpus-based study examines how writers of tweets about organic food use hashtags to direct readers towards the preferred tweet interpretation while expressing their stance to organic food. Our aim is to identify the functions stance-conveying hashtags serve in these tweets. To this end, we draw on Du Bois’ (2007) approach to stance and Francis’ (1994) analysis of metalinguistic labels. We an

Public health nurses experience of mental health encounters in the context of primary health care: a constructivist grounded theory study

BackgroundIn primary health care people with mental health needs are often overlooked or masked with physical complaints. It has been suggested that public health nurses lack sufficient knowledge when encountering people with mental health problems. Low levels of mental health literacy among professionals are associated with negative patient outcome. There is a need to understand public health nur

Effect of CO2 dilution on structures of premixed syngas/air flames in a gas turbine model combustor

The impact of CO dilution on combustion of syngas (a mixture of H2, CO, and CH4) was investigated in a lab-scale gas turbine model combustor at atmospheric pressure conditions. Two mild dilution levels of CO2, corresponding to 15% and 34% of CO2 mole fraction in the syngas/CO2 mixtures, were experimentally investigated to evaluate the effects of CO2 dilution on the flame structures and the emissio

The role of pain and walking difficulties in shaping willingness to undergo joint surgery for osteoarthritis : Data from the Swedish BOA register

OBJECTIVES: To investigate whether the association between pain intensity and willingness to undergo surgery is explained by walking difficulties, in patients with knee or hip osteoarthritis (OA).METHODS: This is an observational study using data from the Better management of patients with Osteoarthritis (BOA) register, which collects data from a publicly financed self-management programme for peo

Student union membership and political identification: network effects

The vast majority of students at universities in Sweden are members of student unions. Universities strongly encourage students to enter unions as they give access to discounts, social events, clubs, and internships. Student unions are tasked with representing students towards the university. In addition, union membership in Sweden is rarely believed to have a political connotation. While often be

Cognitive effects of Lewy body pathology in clinically unimpaired individuals

α-Synuclein aggregates constitute the pathology of Lewy body (LB) disease. Little is known about the effects of LB pathology in preclinical (presymptomatic) individuals, either as isolated pathology or coexisting with Alzheimer's disease (AD) pathology (β-amyloid (Aβ) and tau). We examined the effects of LB pathology using a cerebrospinal fluid α-synuclein-seed amplification assay in 1,182 cogniti

Behaviour, thoughts, and feelings : Informal second language learning through the lens of task engagement

This chapter provides an introduction to task engagement as a framework for better understanding how individuals participate in and learn from second language activities in their leisure time. Although the concept is relatively new to second language acquisition research, engagement has been extensively studied in educational science, as a way of operationalising different aspects of students’ par