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This paper discusses some problems in associating definitions and judgments of criminal unaccountability, e.g. criminal insanity, to psychiatric constructs, i.e., diagnoses, symptoms and related constructs of functional impairment. The aim is to highlight this relationship as to why it is inevitably challenging at a conceptual level. The backdrop of the paper is that the dependence between legal a

Pathological ossification is seen affecting different organs across the body. This includes the Achilles tendon, where the healing process after rupture can be impaired by heterotopic ossifications (HO). The formation pathways for HO in tendons are still debated, and one reason for this is our limited knowledge of their structure and composition in 3D. This study utilizes a multimodal 3D character

Rationale: Long-term exposure to air pollution contributes to chronic respiratory diseases, including asthma and chronic obstructive pulmonary disease (COPD). While the effect of fine particulate matter (PM2.5) and nitrogen dioxide (NO2) are supported by evidence, the contribution of black carbon (bc), a combustion-related pollutant, remains unclear. Objectives: To investigate associations of long

Ionizing radiation impairs male fertility, but the ultrastructural lesions linking radiation to sperm dysfunction remain unclear. The sperm annulus, a ring structure essential for flagellar in-tegrity, is a potential but unresolved target. Here, we integrate synchrotron X-ray ptychography, cryogenic soft X-ray tomog-raphy, electron microscopy, and confocal imaging for cross-scale visualization of

Data centers serve as crucial infrastructure for the development of the digital economy, and maintaining their thermal environment is essential for ensuring that computing equipment can execute workload properly. Thermal environment management and workload scheduling are mutually influential; however, current research often treats them separately, overlooking their bidirectional coupling relations

Objective: To describe the clinical and ultrasound characteristics of ovarian mature cystic teratoma containing malignancy. Methods: This was an international, retrospective, observational study. We invited 19 (oncological or non-oncological) gynecological centers to provide clinical and ultrasound information on cases of histologically confirmed ovarian mature cystic teratoma containing malignanc

Background: Hippocampal sclerosis of aging (HS-A), a common cause of dementia, can currently only be diagnosed at autopsy. We aimed to identify and evaluate MRI metrics to distinguish HS-A from Alzheimer’s Disease neuropathologic change (ADNC) and cases with limited/no pathology. Methods: HS-A (N = 5), ADNC (N = 10), and limited/no pathology (N = 12) cases were compared on postmortem MRI signature

Introduction: Laparoscopic-assisted renal cryoablation (LRC) is a treatment option for small renal masses (SRMs), offering a nephron-sparing alternative to partial nephrectomy. This study evaluated long-term oncologic outcomes and perioperative complications after LRC in a single-center cohort. Methods: We conducted a retrospective single-center review of 52 patients who underwent LRC for SRMs ≤4

Context: Levothyroxine (LT4) is the primary treatment of hypothyroidism. Despite adequate LT4 substitution some patients experience symptoms and the use of adjunct liothyronine (LT3) has increased. Several trials show no clear advantage of LT4 + LT3, and observational studies report conflicting results. Objective: We aimed to assess the relationship between initiation of LT3 treatment and psychiat

With global warming, precipitation variability is increasing, affecting water availability and consequently ecosystem functioning and carbon uptake. Semi-arid ecosystems are very sensitive to changes in water availability since both gross primary productivity (GPP) and ecosystem respiration (Reco) are strongly linked to it, contributing most to the interannual variability and trend of the global l

The stellar-mass–halo-mass (SMHM) relation is central to our understanding of galaxy formation and the nature of dark matter. However, its normalization, slope, and scatter are highly uncertain at dwarf galaxy scales. In this paper, we present DarkLight, a new semi-empirical dwarf galaxy formation model designed to robustly predict the SMHM relation for the smallest galaxies. DarkLight harnesses a

Introduction: Timely diagnosis and treatment are essential for improving outcomes and quality of life in patients with transthyretin (ATTR) amyloidosis. Early multisystem manifestations are often unrecognized, leading to diagnostic delays and misdiagnosis. Large-scale, multicountry, observational studies are needed to better characterize the real-world trajectory of these patients. Methods: OverTT

Research on the underwater archaeological site of Bulverket has been ongoing forover 100 years. Bulverket was a large square wooden platform, built in the middle ofa large shallow lake on northern Gotland in the early 1130s. On top of the platformwere numerous houses constructed with a wide variety of contemporary buildingtechniques, including wickerwork, stave construction, corner-post constructi

Essay on Lund university as a cultural institution

MicroRNAs (miRNAs) have emerged as central regulators of pancreatic islet biology, influencing β-cell development, proliferation, and function. In type 2 diabetes (T2D), both adaptive and maladaptive miRNA responses shape β-cell compensation and progressive secretory dysfunction. Here, we review current insights into the regulation of insulin secretion, with a focus on exocytosis and the autocrine