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Importance: Although the most common recent approach in Alzheimer disease drug discovery is to directly target the β-amyloid (Aβ) pathway, the high prevalence of apolipoprotein E ϵ4 (APOE ϵ4) in Alzheimer disease and the ease of identifying ϵ4 carriers make the APOE genotype and its corresponding protein (apoE) an appealing therapeutic target to slow Aβ accumulation. Objective: To determine whethe

Beryllium reflectors are used at spallation neutron sources in order to enhance the low-energy flux of neutrons emanating from the surface of a cold and thermal moderator. The design of such a moderator/reflector system is typically carried out using detailed Monte-Carlo simulations, where the beryllium reflector is assumed to behave as a poly-crystalline material. In reality, however, inhomogenei

Adipose tissue plays a major role in regulating whole-body energy metabolism. While the biochemical processes regulating storage and release of excess energy are well known, the temporal organization of these events is much less defined. In this study, we have characterized the presence of small surface-associated lipid droplets, distinct from the central droplet, in primary human adipocytes. Base

Background: Undernutrition contributes to nearly 50% of all child deaths in the world, yet there is conflicting evidence regarding the association between nutritional status and postoperative complications. The aim was to describe the preoperative nutritional status among pediatric surgery patients in Zimbabwe, and to assess if nutritional status was a risk factor for adverse postoperative outcome

Aim: To explore if electrographic status epilepticus (ESE) after cardiac arrest causes additional secondary brain injury reflected by serum levels of two novel biomarkers of brain injury: neurofilament light chain (NfL) originating from neurons and glial fibrillary acidic protein (GFAP) from glial cells. Methods: Simplified continuous EEG (cEEG) and serum levels of NfL and GFAP, sampled at 24, 48

This study explores the relationship between local government dissemination of COVID-19 information and partisanship. The unit of analysis is all official county government websites in the United States. In particular, we investigate if there is a correlation between the overall partisanship of a county and whether a county government's website 1) mentions COVID-19, and 2) provides safety instruct

Background: Life expectancy is increasing all over the world. To be able to support this positive development, health interventions focusing on promotion and prevention are crucial. Preventive home visits represent one example of a health intervention which addresses both promotion through a supportive dialogue and prevention by giving advice. However, to give support and advice that older persons

Due to dramatic developments in international affairs and the starkly diverging foreign policy visions of the two candidates, Jimmy Carter and Ronald Reagan, foreign policy occupied a usually prominent role in the 1980 U.S. presidential election. A central component of the foreign policy debate was the appropriate role for human rights concerns in American foreign relations. Nevertheless, neither

Objectives: High-quality leadership and chairing skills are central components in team performance during multidisciplinary team (MDT) meetings. We hypothesized that the recently developed A Tumor Leadership Assessment inStrument (ATLAS) could provide relevant information to support more detailed insights into MDT chairing and leadership aspects of relevance for team feedback and targeted improvem

Processing of lignocellulosic biomass is complex due to the heterogeneity of the substrate, but also due to lengthy unit operations, which complicates process control including for enzymatic saccharification. Methods for predicting enzymatic saccharification yield based on the properties of the pretreated biomass would be advantageous to process optimization and control. Biomass-water interaction

In this paper, we examine the exchange of crops and livestock through the application of strontium (87Sr/86Sr) isotope analysis on cereal grains and faunal tooth enamel from the regional center of Uppåkra and three nearby settlements in Scania, southern Sweden, dating to the first millennium AD. Around a third of the fauna have non-local 87Sr/86Sr values, indicating the import of livestock from se

This study was focused on the synthesis and characterization of a fully bio-based unsaturated polyester resin (UPR) with good thermal properties suitable for the commercial production of composite polymers. UPRs based on different ratios of bio-based furan dicarboxylic acid (FDCA), itaconic acid, and diols were synthesized. The unsaturated polymers prepared were evaluated by differential scanning

Background: Haemodynamic studies in children are rare and most studies have included few subjects in the youngest age group. Haemodynamic variables need to be indexed to establish a reference of normality that is valid in all populations. The traditional way to index haemodynamic variables with body surface area (BSA) is complicated in young children due to its non-linear relationship with body we

Understanding 3d human interactions is fundamental for fine grained scene analysis and behavioural modeling. However, most of the existing models focus on analyzing a single person in isolation, and those who process several people focus largely on resolving multi-person data association, rather than inferring interactions. This may lead to incorrect, lifeless 3d estimates, that miss the subtle hu

Mitochondrial fusion and fission are dynamic processes regulated by the cellular microenvironment. Under nutrient starvation conditions, mitochondrial fusion is strengthened for energy conservation. We have previously shown that newborns of Ubl4A-deficient mice were more sensitive to starvation stress with a higher rate of mortality than their wild-type littermates. Ubl4A binds with the actin-rela

The European Spallation Source being constructed in Lund, Sweden will provide the user community with a neutron source of unprecedented brightness. By 2025, a suite of 15 instruments will be served by a high-brightness moderator system placed above the spallation target. The ESS infrastructure, consisting of the proton linac, the target station, and the instrument halls, allows for implementation

Purpose: The study aimed to explore family caregivers’ support needs prior to allo-HSCT, how these change over time and whether they are associated with demographic factors and caregiver outcome. Methods: This longitudinal repeated measure study included 87 family caregivers of allo-HSCT recipients: 63% were partners, 74% women, 65% lived with the recipient, and their mean age was 54 years. They c

In this paper we study the convex envelopes of a new class of functions. Using this approach, we are able to unify two important classes of regularizers from unbiased non-convex formulations and weighted nuclear norm penalties. This opens up for possibilities of combining the best of both worlds, and to leverage each method’s contribution to cases where simply enforcing one of the regularizers are

Epidemics and pandemics have shaped human history and will continue to do so. The COVID-19 crisis has shown that there is need to understand how Europe can ensure better management of and preparedness for them. This joint advice builds on lessons learned from the current and from previous pandemics. It analyses their complexity, drawing on insights from research and scholarship and taking European