Poly(ethylene glycol) (PEG) polymers and PEG-conjugated lipids are widely used in bioengineering and drug transport applications. A PEG layer in a drug carrier increases hydrophilic repulsion, inhibits membrane fusion and serum opsonin interactions, and prolongs the storage and circulation time. It can also change the carrier shape and have an influence on many properties related to the content re

Epilepsy is one of the most devastating neurological diseases and despite significant efforts there is no cure available. Occurrence of spontaneous seizures in epilepsy is preceded by numerous functional and structural pathophysiological reorganizations in the brain-a process called epileptogenesis. Treatment strategies targeting this process may be efficient for preventing spontaneous recurrent s

This article explores middle managers in the professions from their position in the sandwiched middle. Based upon interviews with senior academics in management roles and their subordinates in UK business schools, we investigate this experienced middle through a metaphor that informs one particular subject position: to be an umbrella carrier. This position entails protecting subordinates from what

The shortest light pulses produced to date are of the order of a few tens of attoseconds, with central frequencies in the extreme UV range and bandwidths exceeding tens of electronvolts. They are often produced as a train of pulses separated by half the driving laser period, leading in the frequency domain to a spectrum of high, odd-order harmonics. As light pulses become shorter and more spectral

The objective is to estimate the number of deaths attributable to cardiovascular diseases and diet-related cancers that could be prevented or delayed in Sweden if adults adhere to the official dietary recommendations. We used an age-group and sex-specific epidemiological macro-simulation model to estimate preventable deaths due to the discrepancies between actual intake and recommended intake of c

The ability to repair or promote regeneration within the adult human brain has been envisioned for decades. Until recently, such efforts mainly involved delivery of growth factors and cell transplants designed to rescue or replace a specific population of neurons, and the results have largely been disappointing. New approaches using stem-cell-derived cell products and direct cell reprogramming hav

Above 6 GHz, radio frequency (RF) electromagnetic field (EMF) exposure from the mobile communication user equipment (UE) should be assessed in terms of incident power density, rather than specific absorption rate as below 6 GHz. Such regulatory RF EMF restrictions will constrain the transmit power of the UE and its peak equivalent isotropically radiated power (EIRP). This paper provides an analysi

Halide perovskites have continued to rise as attractive light absorber materials, mainly driven by their potential wide applications in the fields of solar cells, photodetectors, lasers and others. However, Pb-containing perovskites are poisonous and could cause serious potential problems to our environment. Thus, there is a strong desire to develop lead-free perovskites as environmentally friend

EU criminal justice is a fast developing and challenging area of EU law and policy that requires scholars from different disciplines to join forces. This book is a first attempt to establish such synergies. Coming from different angles, the authors deal with questions in the area of EU substantive criminal law, such as when criminalisation of conduct is an appropriate choice; how the process of (d

This introduction explains the aim, context and purpose of the book as well as the need for an interdisciplinary study of EU criminal justice. It also discusses the content of the book and the limitations to the study. In particular it discusses the need for and problems with a more evidence-based approach to lawmaking in the area of EU criminal law.

This chapter addresses the EU’s policy in the field of procedural criminal law. It sketches how issues similar to those discussed in the field of substantive EU criminal law can arise in the field of procedural law and argues that they should also be studied from within multiple disciplines. It tentatively proposes that a more evidence- based understanding of the exercise of competences in this fi

The fluorinated 4-quinolones are a 'new' group of antibiotics with a broad antibacterial spectrum. They are already widely used in clinical practice. Previous studies have shown that these drugs increase the uptake of [3H]-thymidine into DNA of mitogen-stimulated lymphocytes but inhibit cell growth and immunoglobulin secretion. This study shows that the 4-quinolones strongly (up to 100 times) incr

At clinical concentrations, ciprofloxacin did not inhibit mitochondrial DNA replication, oxidative phosphorylation, protein synthesis, or mitochondrial mass (transmembrane potential). No difference in supercoiled forms of DNA was observed. The tetracyclines and chloramphenicol inhibited protein synthesis at clinically achievable concentrations, while rifampin, fusidic acid, and clindamycin did not

Caloplaca asserigena is known to have a secondary compound different from other species of Teloschistaceae in the Northern Hemisphere. Studies of the secondary chemistry of the Australian Teloschistaceae have revealed the same compound to be present in Marchantiana michelagoensis and Caloplaca marchantiorum. Subsequent molecular studies based on three genes support the affinity of C. asserigena an