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With the emergence of autonomous vehicles comes the requirement of adequate and rigorous testing, particularly in critical scenarios that are both challenging and potentially hazardous. Generating synthetic simulation-based critical scenarios for testing autonomous vehicles has therefore received considerable interest, yet it is unclear how such scenarios relate to the actual crash or near-crash s
Background: Knee pain is often an early sign of knee osteoarthritis (KOA). Physical activities (PA) constitute the recommended regime to those affected. However, knee-loading PA at work is linked to an increased risk for KOA. The primary aim of this study was to investigate associations between knee pain and accelerometer-measured knee-loading PA, at work and leisure respectively. The secondary ai
Oxidative stress and alterations in redox signalling have been implicated in the pathophysiology of myocardial infarction (MI). NADPH oxidase (Nox) is an important source of reactive oxygen species (ROS) in the infarcted myocardium. Alarmin S100A8/A9 amplifies acute myocardial inflammation in MI and has been shown to be a promising therapeutic target to improve cardiac function post-MI. We aimed t
Background: Per- and polyflouralkyl substances (PFAS) are a group of persistent chemicals used extensively in industries and consumer products due to their water-repellent properties. Studies have linked PFAS exposure to adverse health effects, and human exposure to PFAS, especially during pregnancy, is of great concern. In this study, we report how serum PFAS concentrations during pregnancy corre
In recent years, WUI fire evacuation models have started to be developed. Several now exist, although they are primarily research tools unable to be applied in practice or commercially available tools with limited functionality. For this step – moving from research to practice – such models need to build their credibility through data for their development, testing and application. The WUI-NITY to
Open-pit coal mine reconstructed ecosystems are ecologically fragile. Retained early stage topsoil is usually not enough to maintain plant growth. For this purpose, we used root exudates to fertilize the reconstructed soil and improve the functioning of the soil microorganism ecology. The roots’ exudates increased the concentration of organic matter and total nitrogen by 16–39%. Within a certain c
The Journal Digital Corpus (JDC) is a corpus comprising transcriptions of Swedish historical newsreels, primarily sourced from the SF Veckorevy newsreels produced between the early 1910s and the 1960s. JDC includes transcribed speech from 2,553 newsreels (over two million words) and intertitles from 4,333 videos. Utilizing custom-built Python libraries, SweScribe and stum, the corpus facilitates u
Background: Studies on national policies for biologics are warranted. Objectives: To map and compare national healthcare set-ups for prescription, start, switch, tapering, and discontinuation of biologic/targeted synthetic disease-modifying antirheumatic drugs (DMARDs) in patients with psoriatic arthritis and axial spondyloarthritis across Europe, and assess the healthcare set-ups in relation to c
Hypothesis: The structure and functionality of pea albumin can be described in detail as a combination of its main fractions, PA1 and PA2. Experimental: PA1 and PA2 were purified from a Pea Albumin extract (PA) using size exclusion chromatography, and characterized by two-dimensional gel electrophoresis. Their secondary structure was analyzed using Fourier-Transform Infrared Spectroscopy (FTIR). T
Metachromatic leukodystrophy (MLD) is a rare autosomal recessive lysosomal storage disorder caused by disease-causing variants in the gene coding for arylsulfatase A, leading to deficient enzyme activity and subsequent accumulation of sulfatides. MLD is characterized by demyelination and neurodegeneration of the central and peripheral nervous system, manifesting as progressive motor and cognitive
Uncertainty in the mechanical properties and modal characteristics of Cross-Laminated Timber (CLT) significantly impacts its predictive design and analysis. While previous studies have focused on identifying sensitive mechanical properties of CLT using model updating, the uncertainty quantification of these properties and their influence on natural frequencies and modes remain underexplored. This
Uveal melanoma (UM) is a rare but frequently metastasizing cancer. Genome-wide association studies have identified three common genome-wide significant germline risk loci. Here, we perform a genome-wide association study on 401 new cases and conduct a meta-analysis with three independent previously published cohorts for a total sample size of 2,426 cases. We confirm the three previously identified
