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This thesis investigates the use of performance bounds in radar signal processing, with particular emphasis on the Cramér-Rao bound (CRB) and its misspecified and Bayesian variants, the MCRB and the BCRB. These bounds characterize fundamental limits on estimation accuracy and can therefore be used to assess the performance attainable under a given signal model. However, they can also be used prosp
Using nationwide register data, individuals aged 15–60 years registered as suspects of firearm homicide, attempted firearm homicide, or conspiracy/preparation to commit such offenses (firearm homicide+) between 2000 and 2020 were matched to population controls. Conditional logistic regression examined the association between immigrant background and registered suspicion of firearm homicide+, adjus
PURPOSE: Patients with the traditional definition of multimorbidity, with 2 or more chronic diseases, are a very large and heterogeneous group who differ considerably depending on which set of disorders they suffer from. This paper describes the baselines characteristics of the GerMoT cohort and investigates if the GerMoT inclusion criteria could be used to identify a subgroup of multimorbid patie
INTRODUCTION: Although there are more women than men working in the healthcare system in Europe, reports of gender-related inequities within the healthcare workforce are still emerging. Our study aimed to gather insights from women, representing different healthcare professions, who work in the field of geriatric medicine and gerontology, to better understand their perspectives and experiences.MET
Medan opinionsmätningarna duggade tätt låg en annan fråga och skvalpade under ytan i valrörelsen: om framtiden för AI-bolagen och hur datacenter ska byggas och förses med el i det svenska landskapet. Här finns en skiljelinje som kan ha påverkat valutgången och kommer göra det framöver.
En av valrörelsens stora snackisar var om Liberalerna skulle klara spärren. Mycket tyder på att L åtnjöt en lika strid ström av taktiska röster från Moderatsympatisörer som Kristdemokraterna gjorde vid valet 2010.
Teamwork in complex organizational contexts is frequently characterized by a lack of clarity regarding which relationships are relevant at any given moment, that is, by in-situ membership ambiguity, often enacted as subgrouping. Leadership is particularly relevant in such moments, as an organizing force capable of enacting the full team as the in-situ relevant membership. Contemporary leadership tTeamwork in complex organizational contexts is frequently characterized by a lack of clarity regarding which relationships are relevant at any given moment, that is, by in-situ membership ambiguity, often enacted as subgrouping. Leadership is particularly relevant in such moments, as an organizing force capable of enacting the full team as the in-situ relevant membership. Contemporary leadership t
Gene therapy with AAV vectors carrying genes for neuropeptide Y and its receptor Y2 has been shown to inhibit seizures in multiple animal models of epilepsy. It is however unknown how the AAV serotype or the sequence order of these two transgenes in the expression cassette affects the actual parenchymal gene expression levels and the seizure-suppressant efficacy. To address these questions, we com
Epilepsy is a central nervous system disorder causing uncontrollable seizures. One-third of patients do not respond to current medications, necessitating new treatments. This study targeted epileptogenesis, the process leading to chronic epilepsy, using human mesenchymal stem cells (MSCs) in a rodent model. MSC transplantation can positively affect neurodegenerative diseases by modifying inflammat
I dag används ofta dukmembran tillverkade av termoplast i vägtunnlar eller andra undermarksanläggningar för att avleda läckande vatten från berget. Trafikverket har flera funktionskrav för dukmembran, varav ett berör brandskydd. Generellt gäller att en högre brandklass ofta innebär försämrade egenskaper inom andra områden, såsom styrka och tålighet. Därför används i många projekt dukmembran med br
Bacteria deploy virulence factors to subvert host immunity; yet the molecular details of these interactions often remain limited. Here, we reveal the structure and host interactome of the Streptococcus pyogenes nuclease A (SpnA). We characterize the structure and dynamics of SpnA using hydrogen-deuterium exchange mass spectrometry and single-particle electron cryo microscopy, yielding the first st
Educational change is not simply a matter of reform. The political project of changing education may itself turn education into a site of struggle over what education should be, what kinds of human beings – and, by extension, what kind of society – it is expected to produce, and what futures it should make possible. This thesis explores the Iranian state’s policy project of changing education afte
City densification offers several sustainability benefits. However, in areas near railways, concrete buildings can be preferred over timber buildings, despite timber being a more environmentally friendly option. This preference is primarily due to concerns about vibrations affecting timber buildings, which has limited their adoption. This paper investigates dynamic substructuring for analyzing tim
BACKGROUND: Weight bias and stigma have transformed body weight from a purely biological attribute into a complex social phenomenon. Social and health scientists continue to critically examine how weight stigmatising discourses and biased perceptions shape attitudes, beliefs and everyday experiences. Studies show that socially mediated subjectivities profoundly affect women's health-related behavi
Females who have larger bodies or obesity may be at an increased risk for experiencing infertility. Problematically, both weight or body size and infertility are stigmatized, harming quality of care. We conducted a scoping review to understand the lived experiences of patients who may be subjected to intersecting stigmas of weight and infertility in healthcare. Searches included six databases (Med
Climate change represents a major threat to global biodiversity and associated ecosystem functions, including pollination. In both natural and agricultural environments, semi-natural grasslands represent crucial foraging and nesting habitats for wild pollinators such as bumblebees, for which temporal population trends in these habitats remain understudied. Here, we use data from a large-scale syst
Background – Trastuzumab deruxtecan (T-DXd) is effective in HER2-expressing metastatic breast cancer (mBC), yet inter-patient benefit varies. The current reference biomarker—HER2 immunohistochemistry (IHC) on tumor biopsies—is insufficient as a sole predictor of response. HER2-targeted PET/CT offers non-invasive, whole-body, real-time assessment of target expression. We hypothesize that HER2-targe
The use of ground-source heat pump systems for heating and cooling of buildings is becoming increasingly widespread throughout the world. The most common application of ground-source heating and cooling systems uses vertical boreholes. The primary function of a ground heat exchanger is to efficiently transfer heat between the ground and an above-ground heating and/or cooling load. The heat transfe
Twenty-five years ago, the book The Ecology of Adaptive Radiation by Dolph Schluter presented a testable framework that integrated ecology, genetics, and natural history to explain the mechanisms driving adaptive radiation, the rapid diversification of a single lineage into multiple species occupying distinct ecological niches. One important contribution was to re-orientate the study of adaptive r
