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Background: Chronic kidney disease (CKD) affects 6–10% of adults and often remains undiagnosed until advanced stages, leading to inadequate management. This study compared diagnosed, proxy-diagnosed, and undiagnosed CKD patients regarding prevalence, clinical assessment, nephroprotective treatment, healthcare utilization, and mortality. Methods: This retrospective observational study analyzed Regi
Bygg- och fastighetsbranschen är en av EU:s största konsumenter av naturresurser och producenter av avfall vilket gör en skyndsam omställning till ett mer cirkulärt byggande högst nödvändig. För att lyckas krävs en grundläggande förändring av produkt- och materialflöden i branschen, med fokus på att förebygga avfall, minska uttaget av naturresurser och förlänga produkters livslängd.Återbruk av bygThe construction industry remains one of the largest contributors to resource consumption and waste generation in the EU, making the transition to circular construction both urgent and essential. However, the transition towards a circular construction and real estate industry requires a fundamental shift in material flows, prioritising waste prevention, reducing extraction of natural resources, an
Self-harm, including nonsuicidal self-injury and suicide attempts, is common among youth, associated with elevated psychopathology, suicide risk, and increased demand for clinical services. Despite advances in understanding and treatment, few interventions have demonstrated efficacy in randomized controlled trials (RCTs), which are considered the gold standard for evaluating treatment effects by r
Purpose: This study aimed to evaluate the ability of a thigh-worn accelerometer to detect walking during daily life in individuals with Lumbar Spinal Stenosis (LSS). Two hypotheses were made regarding how walking measurements from the accelerometer, a walking test, and an ankle-worn StepWatch would relate in order for the accelerometer to be valid. The hypotheses were: (a) there is no difference b
Venetoclax-obinutuzumab (Ven-Obi) is a standard first-line therapy for chronic lymphocytic leukemia (CLL). The impact of age, fitness, and dose reductions remains unclear. We analyzed patients treated with Ven-Obi in the CLL13 and CLL14 trials, excluding patients with TP53 aberrations. Fitness was assessed using the cumulative illness rating scale (CIRS, >6) and creatinine clearance (≤70 mL
Background: The Influenza – Monitoring Vaccine Effectiveness in Europe (I-MOVE/I-MOVE+) and Vaccine Effectiveness, Burden and Impact Studies (VEBIS) hospital networks have conducted seasonal multicentre, test-negative, case–control studies in Europe to measure influenza vaccine effectiveness (IVE) since 2015/16. We measured the effect of chronic conditions on VE of influenza A subtypes among older
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by a progressive loss of motor neurons. Neuroinflammation is apparent in affected tissues, including increased T cell infiltration and activation of microglia, particularly in the spinal cord1,2. Autoimmune responses are thought to have a key role in ALS pathology, and it is hypothesized that T cells contribute to the
Plasmacytoid dendritic cells (pDCs) are major producers of type I/III interferons. As interferons are crucial for antiviral defense, pDCs are assumed to play an essential role in this process; however, robust evidence supporting this dogma is scarce. Genetic or pharmacological manipulations that eliminate pDCs or disrupt their interferon production often affect other cells, confounding interpretat
Solid-state electrolytes, such as lithium lanthanum zirconium oxide (LLZO), show promise as technologies for next-generation high-energy-density batteries, but commercial development has been hindered by a lack of scalable processing methods. Current fabrication methods are costly or require long annealing steps to create dense films. We report an atmospheric pressure blown-arc nitrogen plasma jet
Solar-driven hydrogen production stores renewable energy chemically but suffers from efficiency limitations due to the slow hole transport-dominated recombination, which caused by high valence band degeneracy and hole effective mass. Targeted hole trap regulation is essential to minimize these losses and enhance photocatalytic H2 evolution performance for practical applications. This study address
We explore the challenges facing the current academic training of economists in small European countries such as Sweden. The monolithic focus on publishing in the top-five journals, which prioritizes methodological rigor over problem-driven research, is often a threat to social relevance and policy applicability. This limits pluralism, excludes many talented economists, and fails to prepare gradua
This paper presents a novel approach to economic dispatch (ED) optimization in power systems through the application of Proximal Policy Optimization (PPO), an advanced reinforcement learning algorithm. The economic dispatch problem, a fundamental challenge in power system operations, involves optimizing the generation output of multiple units to minimize operational costs while satisfying load dem
We introduce lower-bound certificates for classical planning tasks, which can be used to prove the unsolvability of a task or the optimality of a plan in a way that can be verified by an independent third party. We describe a general framework for generating lower-bound certificates based on pseudo-Boolean constraints, which is agnostic to the planning algorithm used. As a case study, we show how
Employing the term “green nationalism” in the broad sense of nationalist ideologies that concern themselves with the natural environment, we trace a genealogy of green nationalist thought in Japan back to the start of the long 19th century. The changing contours of this discourse are mapped through five representative writers: Moto'ori Norinaga (1730–1801), Shigetaka Shiga (1863–1927). Testurō Wat
The aggregation of tau into amyloid fibrils is associated with Alzheimer’s disease (AD) and related tauopathies. Since different tauopathies are characterized by the formation of distinct tau fibril morphologies, it is important to combine the search of tau aggregation inhibitors with the development of in vitro tau aggregation assays that recapitulate aggregation as it may occur in the brain. Her
High-resolution transmission spectroscopy has become a powerful tool for detecting atomic and ionic species in the atmospheres of ultra-hot Jupiters. In this study, we demonstrate for the first time that the Australian-built Veloce spectrograph on the 3.9-m Anglo-Australian Telescope can resolve atmospheric signatures from transiting exoplanets. We observed a single transit of the ultra-hot Jupite
The presence of lipids after pea protein isolation was related to changes in protein structure and functionality. The aim of this study is to investigate the effects of the presence of lipids, specifically polar endogenous lipids (phospholipids), on pea globulins' (including legumin and vicilin) structure and functionality. Pea globulins were extracted by isoelectric precipitation from defatted an
Therapeutic proteins are essential in modern medicine but are often susceptible to chemical degradation during production, transportation, and storage, which can compromise functionality and even lead to immunogenicity in patients. This study investigates how the structure of the affibody GA-Z affects its chemical stability and how glycerol stabilizes the protein against deamidation and isomerizat
Svenska myndigheter ska enligt vår svenska grundlag vara fristående från regeringen. Är detta fristående tillräckligt för de krav på oberoende som EU-rätten ställer? Den frågan undersöks i detta avsnitt av Sieps Podcast.
