Treatment of melanoma with a BRAF inhibitor (BRAFi) frequently initiates development of BRAFi resistance, leading to increased tumor progression and metastasis. Previously, we showed that combined inhibition of elevated WNT5A and IL-6 signaling reduced the invasion and migration of BRAFi-resistant (BRAFi-R) melanoma cells. However, the use of a combined approach per se and the need for high inhibi

Ulnar nerve compression at the elbow (UNE) frequently affects people of working age. Surgically treated patients may not immediately return to work (RTW) postoperatively. In 2008, the Swedish Social Insurance Agency reformed the national insurance policy. We aimed to examine RTW postoperatively for UNE, variations among surgical methods, and potential risk factors for prolonged RTW (sick leave > 6

This article illuminates (inter)actions and group dynamics of adult volunteers in programs for bereaved children and parents. A focus group interview with seven volunteers in Swedish was conducted. A latent, thematic analysis was conducted, inspired by Braun and Clarke, and Goffman. Two themes were constructed: Personal despair as a motivation for establishing and consolidating voluntary involveme

The early Greek translation of the Qur’an has received little notice, not least due to the many claims that it was a faulty and inadequate attempt of rendering the Qur’an into Greek. This article argues that the faults are very few and minor, and that the early translation (from before 870 CE) should instead be read as a serious example of early Qur’anic interpretation as well as a documentation o

China is urbanizing at an unprecedented rate, but also accelerating the use of water resources and overloading of urban drainage systems. To analyze the impact of urbanization on the drainage-system health in Jinxi, a typical small case area in China, this study proposed an innovative methodological framework for evaluation and prediction based on statistical and modeling methods, which provides a

Background: Studies on risk factors for severe COVID-19 in people of working age have generally not included non-working persons or established population attributable fractions (PAFs) for occupational and other factors. Objectives: We describe the effect of job-related, sociodemographic, and other exposures on the incidence, relative risks and PAFs of severe COVID-19 in individuals aged 18–64. Me

Asynclitism, the most feared malposition of the fetal head during labor, still represents to date an unresolved field of interest, remaining one of the most common causes of prolonged or obstructed labor, dystocia, assisted delivery, and cesarean section. Traditionally asynclitism is diagnosed by vaginal examination, which is, however, burdened by a high grade of bias. On the contrary, the recent

The rescue operations’ environment can impair firefighters’ performance and increase the risk of injuries, e.g., burns and hyperthermia. The bulk and carried weight of heavy protection contributes to lower physical performance, higher metabolic load and internal body heat production. For recommending optimal protection for the tasks and incident scenarios, knowledge of clothing thermal properties

This study utilizes ethnographic methods to inquire how ideas of masculinities are perceived by English-language media professionals and media audiences in Egypt. Using semi-structured interviews and a survey, the aim is to find common narratives on how masculinity is perceived on personal levels and what terms are used to describe men and masculinities, which in turn can be used as the basis for

Cement augmentation of pedicle screws is one of the most promising approaches to enhance the anchoring of screws in the osteoporotic spine. To date, there is no ideal cement for pedicle screw augmentation. The purpose of this study was to investigate whether an injectable, bioactive, and degradable calcium sulfate/hydroxyapatite (CaS/HA) cement could increase the maximum pull-out force of pedicle

Large Eddy Simulation (LES) has rapidly developed into a powerful computational methodology for fluid dynamic studies, between Reynolds-Averaged Navier–Stokes (RANS) and Direct Numerical Simulation (DNS) in both accuracy and cost. High-speed combustion applications, such as ramjets, scramjets, dual-mode ramjets, and rotating detonation engines, are promising propulsion systems, but also challengin

The discovery of the Higgs boson by the ATLAS and CMS collaborations in 2012 concluded the longest search for a particle in the history of particle physics and was based on the largest and most complex physics experiments ever conducted, involving thousands of scientists and engineers from around the world. It provided crucial evidence for a theory developed in the 1960s that describes the existen

The aviation sector is facing a massive change in terms of replacing the currently used fossil jet fuels (Jet A, JP5, etc.) with non-fossil jet fuels from sustainable feedstocks. This involves several challenges and, among them, we have the fundamental issue of current jet engines being developed for the existing fossil jet fuels. To facilitate such a transformation, we need to investigate the sen

Several alkaline earth or rare earth binary monosilicides and -germanides possess complex bonding properties, such as polycation formation exceeding the scope of classical electron counting rules. In this study, we present characterization by powder and single-crystal diffraction and thermal analysis of CeGe, one of the few monogermanides crystallizing in the FeB-type structure. Comparative comput

Background: Estimation of the oxygen extraction fraction (OEF) by quantitative susceptibility mapping (QSM) magnetic resonance imaging (MRI) is promising but requires systematic evaluation. Extraction of OEF-related information from the tissue residue function in dynamic susceptibility contrast MRI (DSC-MRI) has also been proposed. In this study, whole-brain OEF repeatability was investigated, as

The formulation of niosomes is influenced by a number of variables, and these variables may eventually affect the formulation's outcome. One of the elements that can influence the physico-chemical properties of niosomes is the method used in preparation of the formulation. In this study, we established if various methods of preparation have any impact on the prepared vesicles when loaded with 5-fl

A Josephson diode is a nonreciprocal circuit element that supports a larger dissipationless supercurrent in one direction than in the other. In this Letter, we propose a class of Josephson diodes based on supercurrent interferometers composed of Andreev bound state Josephson junctions or interacting quantum dot Josephson junctions, which are not diodes themselves but possess nonsinusoidal current-