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As a prototype of genomics-guided precision medicine, individualized thiopurine dosing based on pharmacogenetics is a highly effective way to mitigate hematopoietic toxicity of this class of drugs. Recently, NUDT15 deficiency was identified as a genetic cause of thiopurine toxicity, and NUDT15-informed preemptive dose reduction was quickly adopted in clinical settings. To exhaustively identify pha

Metazoans must develop from zygotes to feeding organisms. In doing so, developing offspring consume up to 60% of the energy provided by their parent. The cost of development depends on two rates: metabolic rate, which determines the rate that energy is used; and developmental rate, which determines the length of the developmental period. Both development and metabolism are highly temperature-depen

Conventional wisdom pretends that currency devaluations contributed to the Great Depression of the 1930s. This paper examines the impact of nominal exchange rates on foreign trade of 14 industrialized countries 1929-1939. If the idea of competitive devaluation holds, one should expect an increase in exports, along with a decline in imports, to trading partners against which the exchange rate depre

Physical activity is associated with lower risks of developing dementia, Parkinson’s disease (PD) and depression. Furthermore, being physically active prior to brain ischemia appears to help the recovery process. However, previous studies do not differentiate between the two most common forms of dementia, Alzheimer’s disease (AD) and vascular dementia (VaD), when it comes to the association betwee

The influence of the sintering temperature on the mechanical properties of cBN-based ceramic composites with binders in form of vanadium compounds is investigated by methods of physical material science. Two compositions are selected for the study cBN–VC–Al and cBN–VN–Al with 60% vol. of cBN. Samples are obtained by high pressure high temperature sintering (HPHT) in toroid type apparatus with cent

Antalet subventionerade jobb har växt samtidigt som andelen utrikes födda bidragsanställda ökat och andelen funktionsnedsatta minskat. Anställningsbidragen är särskilt frekventa i handels-, restaurang-, städ- och bemanningsbranscherna. I föreliggande studie har samtliga nya anställningsbidrag 2016 i de fyra branscherna i Helsingborg undersökts. En tydlig etnisk segmentering påvisas genom att en beThe number of persons in Sweden with subsidized jobs has grown. At the same time, the share of foreign-born with subsidized jobs has increased, while the share of disabled has declined. The subsidized jobs are most common in the retail, restaurant, cleaning and staffing sectors. The present study investigates all new subsidized jobs in 2016 in these sectors in Helsingborg. The study found clear si

In particle accelerator facilities, single-phase niobium is used in superconducting accelerator components. Machining induced surface quality of such components is strongly connected to the functionality of accelerators. In this study, tool wear development and its influence on the surface quality of Nb workpiece have been investigated in longitudinal turning. Uncoated cemented carbide cutting tooIn particle accelerator facilities, single-phase niobium is used in superconducting accelerator components. Machining induced surface quality of such components is strongly connected to the functionality of accelerators. In this study, tool wear development and its influence on the surface quality of Nb workpiece have been investigated in longitudinal turning. Uncoated cemented carbide cutting too

This paper focuses on the interaction of manual and automatic control in a demanding task where the process is unstable and has actuator limitation. The problem is inspired by control of high performance aircrafts but which is similar to controlling the arm of a Furuta pendulum while maintaining the stability of the pendulum. The task is to control the position of the pendulum arm manually while m

Ochre, waste iron sludge from the treatment of iron rich groundwater for potable use, makes up a significant waste problem. Furthermore, wastewater treatment plants with enhanced biological phosphorus removal and the digestion of sludge are in lack of iron for the prevention of hydrogen sulfide production and the release of phosphorous during anaerobic digestion. Thus, the addition of ochre to ana

This study was aimed at comparing cyclists’ perceptions of comfort when in traffic and when online. Questions about comfort were structured according to three hierarchical levels, namely strategic (city level), tactical (frequent route level) and operational (survey spot level). The purpose is to understand how the cyclists’ perceptions of comfort at different levels vary between questionnaire adm

The critical stress intensity factor for hydrided zirconium-alloys is calculated using a Dugdale type model for a finite crack. The hydride platelets are assumed to surround the ends of the crack. They are located in the process region of the crack tip. The model is used to calculate the temperature dependence of the critical stress intensity factor and the results are compared with measurements p

Crack paths in an elastic layer on top of a substrate are considered. Crack growth is initiated from an edge crack in the layer. The plane of the initially straight crack forms an angle to the free surface. The load consists of a pair of forces applied at the crack mouth and parallel to the interface. Crack paths are calculated using a boundary element method. Crack growth is assumed to proceed al

To ensure that listeners pay attention and do not habituate, emotionally intense vocalizations may be under evolutionary pressure to exploit processing biases in the auditory system by maximising their bottom-up salience. This “salience code” hypothesis was tested using 128 human nonverbal vocalizations representing eight emotions: amusement, anger, disgust, effort, fear, pain, pleasure, and sadne

Background. Secondary hyperparathyroidism (sHPT) is characterized by over function of the parathyroid glands and disturbances in mineral metabolism as a result of renal failure. It is common among patients with end-stage renal disease (ESRD) and it often persists after successful renal transplantation. sHPT is associated with osteoporosis and cardiovascular morbidity and mortality. There are two mBackground. Secondary hyperparathyroidism (sHPT) is characterized by over function of the parathyroid glands and disturbances in mineral metabolism as a result of renal failure. It is common among patients with end-stage renal disease (ESRD) and it often persists after successful renal transplantation. sHPT is associated with osteoporosis and cardiovascular morbidity and mortality. There are two m