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BACKGROUND: Staphylococcus aureus bacteremia is associated with high mortality. Whether cefazolin or an antistaphylococcal penicillin should be preferred for the treatment of methicillin-susceptible S. aureus bacteremia is unclear.METHODS: In an ongoing international Bayesian adaptive platform trial, we conducted an open-label, randomized comparison of cefazolin with an antistaphylococcal penicill
BACKGROUND: Previously considered rare, penicillin-susceptible Staphylococcus aureus (PSSA) bacteraemia has re-emerged worldwide. Although benzylpenicillin might offer advantages in terms of pharmacokinetic and adverse effect profiles, anti-staphylococcal penicillins are recommended for serious infections because of concern over undetected penicillin resistance. We aimed to compare benzylpenicilli
Purpose – This article aims to examine how the agile approach interrelates with project complexity in product development. Design/methodology/approach – The study adopts a case study approach, using multiple dimensions of project complexity as an analytical framework to examine two complementary product development projects that involved the agile approach. Findings – The findings reveal that the
Background: Polygenic risk scores (PRSs) strongly discriminate for prostate cancer risk at the population level. The role of these genetic scores in determining prostate cancer survival is unclear, potentially due to methodological issues. Methods: We included 19,607 men from the Malmö Diet and Cancer Study (MDCS) and the Health Professionals Follow-up Study (HPFS) and analyzed 20-year incidence a
Background: Studies suggest increased phosphate removal when using hemodiafiltration (HDF) compared with hemodialysis (HD), but a complete analytic comparison has not been reported. Methods: We analyzed data from a 6-month prospective, multicenter, cross-sectional study that enrolled patients treated with high-flux HD or HDF and in whom residual kidney phosphate clearances (KrPhos) were measured.
ABSTRACTBackground and Objective: Working from a harm reduction (HR) approach underscores that addiction care professionals (ACPs) serve people with substance use disorder in a non-judgmental environment, encouraging people to seek intervention without abstinence as the ultimate goal. This study aims toexplore and compare the attitudes toward the acceptability of harm reduction among ACPs in SouthABSTRACTBackground and Objective: Working from a harm reduction (HR) approach underscores that addictioncare professionals (ACPs) serve people with substance use disorder in a non-judgmental environment,encouraging people to seek intervention without abstinence as the ultimate goal. This study aims toexplore and compare the attitudes toward the acceptability of harm reduction among ACPs in SouthAf
Carbon monoxide (CO) poisoning is a leading cause of environmental poisoning in the United States and can impair cellular metabolism through both hypoxia and direct mitochondrial toxicity, particularly via inhibition of cytochrome c oxidase (Complex IV, CIV). In this study, we performed a comprehensive assessment of the cerebral metabolic response to CO exposure in a swine model. Twenty-nine swine
Heavy-duty trucks, especially those used in urban areas, are responsible for a disproportionally large share of the external costs of the transportation sector. Policy instruments that target these trucks could thus be efficient measures to reduce negative impact from the traffic sector. This paper presents how heavy-duty trucks operated in Sweden’s two largest cities, Gothenburg and Stockholm, in
Childhood cancer aetiology is poorly understood and is considered to originate in utero and early postnatal life. In this study, we investigated perinatal characteristics as potential risk factors by performing a population-based case-control study, including 1340 cancer cases diagnosed < 19y and born between 1989–2021 in southern Sweden, and 13400 controls matched by sex, year, and municipality o
Rapporten analyserar finansieringen av den offentliga välfärden i Skåne inom ramen för ett decentraliserat system där kommuner och regioner har ett omfattande ansvar för många välfärdstjänster. Finansieringen baseras huvudsakligen på beskattning av förvärvsinkomster, vilket innebär att systemets stabilitet är nära kopplad till utvecklingen av arbetsmarknaden samt skattebasens storlek och fördelnin
Protein-losing enteropathy (PLE) is an uncommon and often underrecognized manifestation of lymphoproliferative disorders and may be difficult to diagnose when conventional gastrointestinal investigations are unrevealing. We present an 82-year-old woman with recurrent hospital admissions initially spanning six months for diarrhea, weight loss, peripheral edema, and persistent hypoalbuminemia. Initi
Background – Air–liquid interface (ALI) cell culture systems have improved the study of host-pathogen interactions in respiratory infections. However, most ALI models lack immune components, limiting their ability to capture epithelial–immune crosstalk. To address this, we developed a dual-cell ALI model incorporating human peripheral blood monocyte-derived macrophages beneath differentiated airwa
We consider the balayage of a measure μ defined on a domain Ω onto its boundary ∂Ω. Assuming that Ω has a corner of opening πα at a point z₀ ∈ ∂Ω for some 0 < α ≤ 2 and that dμ(z) ≅ |z - z₀|²ᵇ⁻² dz² as z → z₀ for some b > 0, we obtain the precise rate of vanishing of the balayage of μ near z₀. The rate of vanishing is universal in the sense that it only depends on α and b. We also treat the case w
Symbioses can be vital on islands, where low species diversity leaves few alternative partners and the failure of associations can cascade into broader community collapse. Key to the functioning of many island ecosystems is the rainforest tree, Pisonia grandis (pisonia). Pisonia attracts nesting seabirds whose guano delivers intense nutrient pulses that fuel coral reef ecosystems. Symbiotic mycorr
The scale of the 21st-century urban housing challenge has prompted state actors in both the Global North and South to adopt increasingly interventionist approaches to ‘affordable’ housing production. This article draws on research in six cities (Shanghai, Nairobi, Paris, Casablanca, Salford and Rome) to discuss the changing relationship between housing, finance and the state through a global compa
The next generation wireless systems will face stringent new requirements, including ultra-low latency, high data rates and enhanced reliability. Large Intelligent Surfaces, is one proposed solution that has the potential to solve these high demands. The real-life deployment of such systems involves different design considerations with non-trivial trade-offs. This paper investigates the trade-off
Strategies that enable ignition of the low cetane alcohol fuels (methanol and ethanol) include intake heating (direct or via hot residual trapping), increased compression ratio (CR), multi-injection strategies, ignition enhancers, and active prechambers. The literature consistently shows alcohol compression ignition (CI) is more efficient than diesel at high loads irrespective of ignition strategy
