Background: Anti-citrullinated protein antibodies (ACPA) have been suggested to have a potential role in both bone loss and pain in rheumatoid arthritis (RA), based on studies in vitro and in animal models. Here we addressed if anti-cyclic citrullinated (anti-CCP) antibodies were associated with osteopenia or pain in patients with RA, at the time for diagnosis. Methods: Baseline data from the BARF

Climate change vulnerability and social marginalisation are often interrelated in and through environments. Variations in climate change adaptation practice and research account for such social-ecological relations to varying degrees. Advocates of ecosystem-based approaches to climate change adaptation (EbA) claim that it delivers social co-benefits to marginalised groups, although scant empirical

Objective: To assess function using the Signals of Functional Impairment (SOFI) instrument over 8 years, to study clinical variables associated with the change, and to study change over time of the SOFI items. Methods: In total, 1,223 patients with early rheumatoid arthritis (RA) from the Better Anti-Rheumatic Farmacotherapy (BARFOT) cohort (mean ± SD age 56.9 ± 15.4 years, 67% women) were include

Clinical reasoning is proposed to represent cognitive processes, skills and decision-making aspects of nursing practice and is important for quality care. It has been suggested that the reasoning processes should be practiced during education to develop decision-making competence among nurses. The aim of the study was to explore and describe clinical reasoning processes at different times during s

In this work, Scheimpflug lidar has been combined with the thermometric technique two-line atomic fluorescence, to carry out stand-off, spatially resolved temperature measurements. Indium atoms were seeded into a modified Perkin-Elmer-burner and two tunable single-mode diode lasers with their wavelengths tuned to 410.17 and 451.12 nm were used to excite the seeded atoms. The fluorescence signal wa

OBJECTIVE:: The authors sought to clarify the etiology of the association between pregnancy and reduced risk of alcohol use disorder. METHODS:: The authors used data from longitudinal population-wide Swedish medical, pharmacy, and criminal registries to evaluate whether rates of alcohol use disorder are lower during pregnancy. They compared pregnant women born between 1975 and 1992 (N=322,029) wit

The porous aquifers in the area called Challapampa are the most important groundwater reservoirs that supply drinking water to Oruro city in the highlands of Bolivia. They consist of unconsolidated fluvial–lacustrine deposits, resting on a complex sedimentary bedrock and covered by a thin surficial clay layer. The settings of these geological units and the structures governing the flow patterns ha

There are three main types of inhalers, dry powder inhalers (DPI, single and multidose), metered dose inhalers (pMDI, spray, suspension and solution), and soft mist (SMI). There are major differences in inhalation technique and handling of the different inhaler types. Different inhalers are well suited for different patients and the choice of inhaler may be crucial for the treatment outcome. It is

Neutrophil recruitment and plasma exudation are key elements in the immune response to injury or infection. Activated neutrophils stimulate opening of the endothelial barrier; however, the underlying mechanisms have remained largely unknown. In this study, we identified a pivotal role of the proinflammatory kallikrein-kinin system and consequent formation of bradykinin in neutrophil-evoked vascula

Context. Detailed chemical abundances of Galactic stars are needed in order to improve our knowledge of the formation and evolution of our galaxy, the Milky Way. Aims. We took advantage of the GIANO archive spectra to select a sample of Galactic disc stars in order to derive their chemical inventory and to compare the abundances we derived from these infrared spectra to the chemical pattern derive

Claudin-2 promotes breast cancer liver metastasis by enabling seeding and early cancer cell survival. We now demonstrate that the PDZ-binding motif of Claudin-2 is necessary for anchorage-independent growth of cancer cells and is required for liver metastasis. Several PDZ domain-containing proteins were identified that interact with the PDZ-binding motif of Claudin-2 in liver metastatic breast can

Aridity and seasonality of precipitation are characteristics of the highland region in Bolivia. Groundwater becomes an important and safe source of water when surficial bodies are intermittent and affected by natural and anthropogenic contamination. Decades of exploitation of the Challapampa aquifer, combined with lack of information required to understand the groundwater circulation, represent a

Chronic lymphocytic leukemia (CLL) patients with differential somatic hypermutation status of the immunoglobulin heavy variable genes, namely mutated or unmutated, display fundamental clinico-biological differences. Considering this, we assessed prognosis separately within mutated (M-CLL) and unmutated (U-CLL) CLL in 3015 patients, hypothesizing that the relative significance of relevant indicator

The role of hormonal factors in the etiology of lymphoid neoplasms remains unclear. Previous studies have yielded conflicting results, have lacked sufficient statistical power to assess many lymphoma subtypes, or have lacked detailed information on relevant exposures. Within the European Prospective Investigation Into Cancer and Nutrition cohort, we analyzed comprehensive data on reproductive fact

PurposeQuantitative MRI (qMRI) yields reproducible “maps” of physiological and/or biophysical tissue parameters. These spatially resolved metrics are mainly used in clinical imaging research for cross-sectional and longitudinal studies. The field of qMRI has considerable expanded during the past two decades. Rather than focusing on particular methods, this talk highlights general concepts of accur

Music in different forms is significant in young people’s lives. Due to the media revolution in our modern society, children of today learn a lot about music on their own by taking part in an increasing production of musical cultures. In this paper different forms of play is applied as a way to reach a deeper understanding of children’s creative music making. This article describes a 2-year empiri