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GFAp and tau protein as predictors of neurological outcome after out-of-hospital cardiac arrest : A post hoc analysis of the COMACARE trial

Aim: To determine the ability of serum glial fibrillary acidic protein (GFAp) and tau protein to predict neurological outcome after out-of-hospital cardiac arrest (OHCA). Methods: We measured plasma concentrations of GFAp and tau of patients included in the previously published COMACARE trial (NCT02698917) on intensive care unit admission and at 24, 48, and 72 h after OHCA, and compared them to ne

Stöd och service till vissa funktionshindrade LSS 2022

Alla som arbetar med myndighetsutövning behöver ha aktuelllagstiftning nära till hands för att garantera klienter och brukareen rättssäker samhällsservice. Motsatsen leder till både personligtlidande för den enskilde och slöseri med tid och pengar för atthantera överklaganden.

China's catching-up in artificial intelligence seen as a co-evolution of corporate and national innovation systems

Inspired by Christopher Freeman's work on how radical technical change opens up for shifts in world leadership and on the role of innovation systems in this process, this paper explores China's emergence as a lead country in artificial intelligence as reflecting a co-evolution of Corporate and National Innovation Systems. Taking Freeman's (1987) work on Japan as our lead, we focus on the domestic

Stöd och service till vissa funktionshindrade LSS 2021

Alla som arbetar med myndighetsutövning behöver ha aktuell lagstiftning nära till hands för att garantera klienter och brukare en rättssäker samhällsservice. Motsatsen leder till både personligt lidande för den enskilde och slöseri med tid och pengar för att hantera överklaganden. LSS 2021 är en nödvändig informations- och lärobok för alla som arbetar med frågor som berör personer med funktionsned

Neurokinins and their receptors in the rat trigeminal system : Differential localization and release with implications for migraine pain

Substance P (SP) and calcitonin gene-related peptide (CGRP) have both been considered potential drug candidates in migraine therapy. In recent years, CGRP receptor inhibition has been established as an effective treatment, in particular as a prophylactic for chronic migraine. Curiously, inhibition of neurokinin receptor 1 (NK1R) failed to alleviate acute migraine attacks in clinical trials, and th

Dietary fatty acids, macronutrient substitutions, food sources and incidence of coronary heart disease: Findings from the EPIC-CVD case-cohort study across nine european countries

BACKGROUND: There is controversy about associations between total dietary fatty acids, their classes (saturated fatty acids [SFAs], monounsaturated fatty acids, and polyunsaturated fatty acids), and risk of coronary heart disease (CHD). Specifically, the relevance of food sources of SFAs to CHD associations is uncertain. METHODS AND RESULTS: We conducted a case-cohort study involving 10 529 incide

Strong Rashba Effect and Different f−d Hybridization Phenomena at the Surface of the Heavy-Fermion Superconductor CeIrIn5

New temperature scales and remarkable differences from bulk properties have increasingly placed the surfaces of strongly correlated f materials into the focus of research activities. Applying first-principles calculations and angle-resolved photoelectron spectroscopy measurements, a strong Rashba effect and spin-split surface states at the CeIn surface of the heavy-fermion superconductor CeIrIn5 a

Using Combinatorial Inkjet Printing for Synthesis and Deposition of Metal Halide Perovskites in Wavelength-Selective Photodetectors

Metal halide perovskites have received great attention in recent years, predominantly due to the high performance of perovskite solar cells. The versatility of the material, which allows the tunability of the bandgap, has led to its use in light-emitting diodes, photo, and X-ray detectors, among other optoelectronic device applications. Specifically in photodetectors, the tunability of the bandgap

Moisture safety in ventilated cathedral roofs

Cathedral roofs are commonly used when constructing small houses in Sweden. In contrast to roof constructions with a cold attic, where frequent moisture damage has been noted, the cathedral roof is difficult to access for inspection. Furthermore, Swedish building regulations sets high demands regarding moisture safety, although there are no clear guidelines for their compliance. Hence, designing a

Early resources lead to persistent benefits for bumble bee colony dynamics

Conditions experienced early in development can affect the future performance of individuals and populations. Demographic theories predict persistent population impacts of past resources, but few studies have experimentally tested such carry-over effects across generations or cohorts. We used bumble bees to test whether resource timing had persistent effects on within-colony dynamics over sequenti

Empowering energy flexibility and climate resilience using collective intelligence based demand side management (CI-DSM)

This work investigates the effectiveness of Collective intelligence (CI) in demand side management (DSM) in urban areas to cope with extreme climate events. CI is a form of distributed intelligence that emerges in collaborative problem solving and decision making. It is used in a simulation platform to control the energy performance of buildings in an urban area in Stockholm, through developing CI

Sex biased expression and co-expression networks in development, using the hymenopteran Nasonia vitripennis

Sexual dimorphism requires regulation of gene expression in developing organisms. These developmental differences are caused by differential expression of genes and isoforms. The effect of expressing a gene is also influenced by which other genes are simultaneously expressed (functional interactions). However, few studies have described how these processes change across development. We compare the

Personalized B cell response to the Lactobacillus rhamnosus GG probiotic in healthy human subjects : a randomized trial

The specific effects of administering live probiotics in the human gut are not well characterized. To this end, we investigated the immediate effect of Lactobacillus rhamnosus GG (LGG) in the jejunum of 27 healthy volunteers 2 h after ingestion using a combination of global RNA sequencing of human biopsies and bacterial DNA sequencing in a multi-visit, randomized, cross-over design (ClinicalTrials

Efficacy and safety of larotrectinib in TRK fusion-positive primary central nervous system tumors

BACKGROUND: Larotrectinib is a first-in-class, highly selective tropomyosin receptor kinase (TRK) inhibitor approved to treat adult and pediatric patients with TRK fusion-positive cancer. The aim of this study was to evaluate the efficacy and safety of larotrectinib in patients with TRK fusion-positive primary central nervous system (CNS) tumors.METHODS: Patients with TRK fusion-positive primary C

How to Enable Collaboration in Open Government Data Ecosystems: A Public Platform Provider’s Perspective

Open Government Data (OGD) is an important driver for open innovation among public entities. However, extant research highlights a need for improved feedback loops, collaboration, and a more demand-driven publication of OGD. In this study, we explore how public platform providers can address this issue by enabling collaboration within OGD ecosystems, both in terms of the OGD, and any related Open