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About half of all cancers have somatic integrations of retrotransposons. Here, to characterize their role in oncogenesis, we analyzed the patterns and mechanisms of somatic retrotransposition in 2,954 cancer genomes from 38 histological cancer subtypes within the framework of the Pan-Cancer Analysis of Whole Genomes (PCAWG) project. We identified 19,166 somatically acquired retrotransposition even
Chromatin is folded into successive layers to organize linear DNA. Genes within the same topologically associating domains (TADs) demonstrate similar expression and histone-modification profiles, and boundaries separating different domains have important roles in reinforcing the stability of these features. Indeed, domain disruptions in human cancers can lead to misregulation of gene expression. H
Chromothripsis is a mutational phenomenon characterized by massive, clustered genomic rearrangements that occurs in cancer and other diseases. Recent studies in selected cancer types have suggested that chromothripsis may be more common than initially inferred from low-resolution copy-number data. Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Can
Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, for which whole-genome and-for a subset-whole-transcriptome sequencing data from 2,658 cancers across 38 tumor types was aggregated, we systematically investigated potential viral pathogens using a consensus approach that integrated three independent pipelines. Viruses were detected in 382 genome and 68 transcriptome dat
Aim: To perform an epigenome-wide association study (EWAS) of serum folate in maternal blood. Methods: Cross-ancestry (Europeans = 302, South Asians = 161) and ancestry-specific EWAS in the EPIPREG cohort were performed, followed by methyl quantitative trait loci analysis and association with cardiometabolic phenotypes. Replication was attempted using maternal folate intake and blood methylation d
Hydrous iron oxide materials with a predefined shape, photo-electrochemical activity, low density (estimated to be 0.32 g cm−3), and high fractal porosity (BET ca. 117 m2 g−1) are formed via internal hydrolytic transformation of the crystalline metal-organic framework MIL-53(Fe) in dilute aqueous hydroxide.
A facile polyethylenimine (PEI)-assisted dip-coating method allows crack-free films of MIL-101(Cr) and MIL-101(Cr)-NH2 to be prepared on alumina supports. The presence of PEI enhances the selectivity of the films for CO2 with respect to N2. The film surfaces can be made hydrophobic by further dip-coating with an aliphatic monocarboxylic acid.
The growth of free-standing surfactant-templated films of inorganic oxides at the air-solution interface is an attractive route to manufacture unsupported mesostructured membranes for a range of potential applications. So far this synthesis method has been relatively neglected due to the fragility of the initial films. More recent work to understand the mechanism of formation has led to developmen
Vi utvärderar coronapolitiken tre år efter pandemins utbrott. Effekterna på överdödligheten av de omfattande nedstängningarna var begränsade samtidigt som de ekonomiska, kostnaderna var signifikanta. Såväl den ekonomiska nedgången som följde av nedstängningspolitiken som obalanserna skapade av finans- och penningpolitiken har gjort stort avtryck och kommer att prägla utvecklingen negativt under lå
Background: Microbial production of propionic acid (PA) from renewable resources is limited by the slow growth of the producer bacteria and product-mediated inhibition. The present study evaluates high cell density continuous PA fermentation from glycerol (Gly) using Acidipropionibacterium acidipropionici DSM 4900 in a membrane-based cell recycling system. A ceramic tubular membrane filter of 0.22
BACKGROUND: Predicting major post-operative complications is an important task for which simple and reliable methods are lacking. A simple scoring system based on intraoperative heart rate, blood pressure and blood loss was recently developed to fill this gap. This system, the Surgical Apgar Score, shows promising results both in terms of validity and in terms of usefulness. The goal of this study
This doctoral dissertation comprises three independent essays which cover different aspects of the currency market.The first paper, Long-run and short-run risk premium in currency market, investigates the risk premium of the long-run and short-run volatility component of exchange rate returns in the currency market. The results indicate that the risk price of long-run volatility innovation is sign
PURPOSE: Conventional computed tomography (CT) images are severely affected by metal artifacts in patients with intracranial coils. Monoenergetic images have been suggested to reduce metal artifacts.The aim of this study was to assess metal artifacts in virtual monoenergetic images (VMIs) reconstructed from spectral brain CT.METHODS: Thirty-two consecutive patients with intracranial coils examined
Är doktrinen om ”alla människors lika värde” tillämpbar också på framtida, ännu icke levande personer? Artikeln argumenterar för ett jakande svar och ger därmed ett bidrag till hur denna vanliga moraliska övertygelse ska förstås och ger dessutom nya argument för omsorg gentemot framtida personer. Doktrinen tolkas som en kritik av handlingar och situationer snarare än som en fullständig värdering a
Population ageing is a fact of all advanced economies. Fewer people are born all the while current members live longer. The support which old people have come to depend on, for example through elderly care and pensions, thus becomes increasingly expensive. This accentuates an assurance problem. Although it has been and still is the case that the young are willing to support the currently old, this
Both decades of the 21st century have been categorized as testing the EU constitutional foundations in the course of different crises, that have been challenging the viability of the European integration and causing alterations to EU constitutional design. The rhetoric of crisis/emergency in the EU has been consistently deployed in the areas of public security, environmental protection, migration Both decades of the 21st century have been categorized as testing the EU constitutional foundations in the course of different crises, that have been challenging the viability of the European integration and causing alterations to EU constitutional design. The rhetoric of crisis/emergency in the EU has been consistently deployed in the areas of public security, environmental protection, migration
