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In a series of papers, we have argued that causal cognition has coevolved with the use of various tools. Animals use tools, but only as extensions of their own bodies, while humans use tools that act at a distance in space and time. This means that we must learn new types of causal mappings between causes and effects. The aim of this article is to account for what is required for such learning of
This article surveys the measurement of historical wealth and income inequality in Germany. We discuss the underlying data sources, the challenges they pose, and the opportunities they create. We also identify two promising avenues for future research. First, we argue that the geographic granularity of German historical statistics provides researchers with the opportunity to investigate the causes
This study analyzes the current state of artificial intelligence (AI) technologies for addressing and mitigating climate change in the manufacturing sector and provides an outlook on future developments. The research is grounded in the concept of general-purpose technologies, motivated by a still limited understanding of innovation patterns for this application context. To this end, we focus on gl
The clinical utility of hemoglobin-based oxygen carriers (HBOC) is limited by adverse heme oxidative chemistry. A variety of tyrosine residues were inserted on the surface of the γ subunit of recombinant fetal hemoglobin to create novel electron transport pathways. This enhanced the ability of the physiological antioxidant ascorbate to reduce ferryl heme and decrease lipid peroxidation. The γL96Y
Consider the quadratic family Ta(x) = ax(1-x) for x ∈ [0, 1] and mixing Collet-Eckmann (CE) parameters a ∈ (2, 4). For bounded φ, set φ˜a := φ-∫ φ dμa, with μa the unique acim of Ta, and put (σa(φ))2 := ∫ φ˜2a dμa + 2Σ i>0 ∫ phi;˜a(φ˜a o T1a) dμa. For any mixing Misiurewicz parameter a∗, we find a positive measure set Ω∗ of mixing CE parameters, containing a∗ as a Lebesgue density point, such that
Northern ecosystems, encompassing boreal forests, tundra, and permafrost areas, are increasingly affected by the amplified impacts of climate change. These ecosystems play a crucial role in determining the global carbon budget. To improve our understanding of carbon uptake in these regions, we evaluate the effectiveness of employing the physically-based Plant Phenology Index (PPI) to estimate gros
In recent years, a vast number of novel antiphage defense mechanisms were uncovered. To facilitate the exploration of mechanistic, ecological, and evolutionary aspects related to antiphage defense systems, we released DefenseFinder in 2021 (Tesson et al., 2022). De-fenseFinder is a bioinformatic program designed for the systematic identification of known antiphage defense mechanisms. The initial r
Diagnosing Alzheimer's disease (AD) poses significant challenges to health care, often resulting in delayed or inadequate patient care. The clinical integration of blood-based biomarkers (BBMs) for AD holds promise in enabling early detection of pathology and timely intervention. However, several critical considerations, such as the lack of consistent guidelines for assessing cognition, limited un
Background and Objectives: Blood services manage the increasingly tight balance between the supply and demand of blood products, and their role in health research is expanding. This review explores the themes that may define the future of blood banking. Materials and Methods: We reviewed the PubMed database for articles on emerging/new blood-derived products and the utilization of blood donors in
Non-invasive prenatal tests (NIPT) to predict fetal red cell or platelet antigen status for alloimmunised women are provided for select antigens. This study reports on massively parallel sequencing (MPS) using a red cell and platelet probe panel targeting multiple nucleotide variants, plus individual identification single nucleotide polymorphisms (IISNPs). Maternal blood samples were provided from
Objective: To evaluate radiographic knee osteoarthritis (OA) progression, development of knee OA, patient-reported outcomes and knee muscle strength at 10-year follow-up after arthroscopic partial meniscectomy (APM) or exercise therapy for degenerative meniscal tears. Methods: Randomised controlled trial including 140 participants, with a degenerative meniscal tear and no or minimal radiographic O
Det här kapitlet fördjupar förståelsen av elevers uppfattningar om läspraktiken shared reading (SR) som ett sätt för dem att utveckla sitt läsengagemang. I kapitlet redovisas en tematisk analys av en fokusgrupp med sju elever i gymnasieskolan som deltagit i sex SR-lektioner inom ramen för SVA1 på ett yrkesprogram. Resultatet relateras till en enkät om deras språkliga bakgrund och läsvanor samt en
None of the global targets for protecting nature are currently met, although humanity is critically dependent on biodiversity. A significant issue is the lack of data for most biodiverse regions of the planet where the use of frugal methods for biomonitoring would be particularly important because the available funding for monitoring is insufficient, especially in low-income countries. We here dis
Background: Multimorbidity is increasingly acknowledged as a significant health concern, particularly among older individuals. It is associated with a decline in quality of life and psychosocial well-being as well as an increased risk of being referred to multiple healthcare providers, including more frequent admissions to emergency departments. Person-centered care interventions tailored to indiv
Background and Objective: Even if treatment with stem cells has been shown to be safe and effective in many patients with stress urinary incontinence (SUI), there is still room for improvement using other regenerative medicine alternatives. Since the beneficial effects of stem cells are probably mediated by secretion of factors rather than by the cells themselves there is a good rationale for furt
Context: The role of glucagon-like peptide-1 (GLP-1) in type 2 diabetes (T2D) and obesity is not fully understood. Objective: We investigate the association of cardiometabolic, diet, and lifestyle parameters on fasting and postprandial GLP-1 in people at risk of, or living with, T2D. Methods: We analyzed cross-sectional data from the two Innovative Medicines Initiative (IMI) Diabetes Research on P
Background: Evidence concerning health care use related to virtual visits is conflicting. More research has been called for regarding the effectiveness of text-based virtual visits (eVisits). Therefore, we investigated patient characteristics, diagnoses, and subsequent health care contacts after eVisits to primary care. Methods: We conducted a register-based cohort study of eVisits to an all-virtu
Background Compression neuropathy, such as carpal tunnel syndrome (CTS), results in changed afferent nerve signaling, which may result in changes in somatosensory brain areas. The purpose of this study was to assess cerebral changes following unilateral CTS and to assess short-term and long-term cerebral effects of guided plasticity treatment using ipsilateral cutaneous forearm deafferentation. M
