The Pharma sector is increasingly under pressure to improve the sustainability of supply chains, as consumers and regulators require greater transparency, efficiency, and accountability. Although Lean 4.0 has created a lot of buzz in the organization, the pharmaceutical sector faces challenges in implementing it. The main goal of this literature review is to identify the challenges of Lean 4.0 for

Kan pedagogiska verksamheter i samhället skapa intresse hos ungdomar så att de väljer att arbeta med vattenfrågor i framtiden? Projektet undersökte utställningen Den hållbara staden på Kretseum i Malmö och Sydvattens kurs Tänk H2O! vid sjön Bolmen i Småland. Bland de positiva effekterna hos eleverna fanns ökad tilltro till den egna kompetensen på området, ökad känsla av att passa in socialt på omr

Fish and other seafood products represent a valuable source of many nutrients and micronutrients for the human diet and contribute significantly to global food security. However, considerable amounts of seafood waste and by-products are generated along the seafood value and supply chain, from the sea to the consumer table, causing severe environmental damage and significant economic loss. Therefor

Cartographic mashup is a powerful tool for users to visualize thematic data together with base maps, and it is increasingly popular due to the better availability of geodata. In current typical mashups, thematic data and base mapscome from different providers without any connection between the data sets, and their scales are not synchronized. In this paper, we firstly explore the problems in such

The idea to create pictorial narratives seems to have occurred long after humans learned to produce iconic images, that is, depictions based on visual similarity to external objects. In Scandinavia, e.g., in Gärde, Sweden or Stykket and Bøla, Norway, early Mesolithic images (e.g., rock carvings from before c. 5000 BCE) often feature animals that are solitary or without suggestion of causal or narr

Mitochondrial dysfunction is a recognized factor in the pathogenesis of deep vein thrombosis (DVT). The role of 7S RNA, a long noncoding RNA that plays an important role in mitochondrial function, in DVT remains unclear. In this study, we aimed to investigate the potential use of 7S RNA as a biomarker in DVT. Plasma samples were obtained from 237 patients (aged 16-95 years) with suspected DVT recr

Very little is known about what family life looked like for settlers in colonial South Africa during the 18th or 19th century, nor how events over these centuries might have affected demographic change. The primary reason for this lacuna is a shortage of adequate data. Historians and genealogists have, over the last century, worked to combine the rich administrative records that are available in t

Polylactic acid nanoparticles (PLA NPs) according to food and drug administration are biodegradable and biocompatible polymers that have received a lot of attention due to their natural degradation mechanism. Although there is already available information concerning the effects of PLA microplastic to aquatic organisms, the knowledge about PLA NPs is still vague. In the present study, we analyzed

The paper embarks on an exploration of how technological advancements are poised to reshape the landscape of future consumption and marketing practices and extend our understanding of whether this trajectory is potentially leading toward a future digital utopia or a dystopia. Drawing upon the theoretical understanding from Marshall McLuhan, this research investigates the metaverse as a novel techn

LPJ-GUESS is an advanced DGVM including detailed forest demography and management, croplands, wetlands, specialised arctic processes, emissions of nonCO2 GHGs and a highly flexible land-use change scheme which tracks transitions between different land-uses. It is the vegetation component of the EC-Earth CMIP6 ESM, the RCA-GUESS regional ESM, and also has a European mode operating at tree species l

Many animals rely on their visual systems to detect, locate or discriminate information in their environment. Environmental ‘visual noise’, however, may interfere with an animal's ability to detect visual information, affecting decision-making processes. A ubiquitous form of visual noise in aquatic environments is caustic flicker: moving light patterns caused by the refraction of light through sur

BACKGROUND: High and low birth weight are independently associated with increased cardiovascular disease risk in adulthood. Clonal hematopoiesis of indeterminate potential (CHIP), the age-related clonal expansion of hematopoietic cells with preleu-kemic somatic mutations, predicts incident cardiovascular disease independent of traditional cardiovascular risk factors. Whether birth weight predicts

Objective To describe the epidemiology of injuries at the Tokyo 2020 Paralympic Games, including injuries sustained in the new sports of badminton and taekwondo. Methods Injury data were obtained daily via the established web-based injury and illness surveillance system (WEB-IISS; 81 countries, 3836 athletes) and local organising committee medical facilities (81 countries, 567 athletes). Univariat

Aims: Despite metformin being used as first-line pharmacological therapy for type 2 diabetes, its underlying mechanisms remain unclear. We aimed to determine whether metformin altered DNA methylation in newly-diagnosed individuals with type 2 diabetes. Methods and Results: We found that metformin therapy is associated with altered methylation of 26 sites in blood from Scandinavian discovery and re

According to Gloger's rule, animal colouration is expected to be darker in wetter and warmer climates. Such environmental clines are predicted to occur in colour polymorphic species and to be shaped by selection if colour morphs represent adaptations to different environments. We studied if the distribution of the colour polymorphic tawny owl (Strix aluco) morphs (a pheomelanic brown and a pale gr

TAR DNA-binding protein-43 (TDP-43) accumulation is the primary pathology underlying several neurodegenerative diseases. Charting the progression and heterogeneity of TDP-43 accumulation is necessary to better characterize TDP-43 proteinopathies, but current TDP-43 staging systems are heuristic and assume each syndrome is homogeneous. Here, we use data-driven disease progression modelling to deriv

How does elite communication influence affective polarization between partisan groups? Drawing on the literature on partisan source cues, we expect that communication from in- or outgroup party representatives will increase affective polarization. We argue that polarized social identities are reinforced by partisan source cues, which bias perceptions of elite communication and result in increased