Patients Referred for Bleeding Symptoms of Unknown Cause : Does Evaluation of Thrombin Generation Contribute to Diagnosis?
INTRODUCTION: Patients with mild to moderate bleeding symptoms referred for coagulation investigation sometimes never receive a definitive diagnosis. Bleed assessment tools have been developed and validated to assess the severity of symptoms. Global coagulation assays, e.g., the thrombin generation test (thrombogram) have a potential to identify hemostatic defects that are not detected in specific