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Consequences of APSP, triangle detection, and 3SUM hardness for separation between determinism and non-determinism

Let NDTIME(f(n),g(n)) denote the class of problems solvable in O(g(n)) time by a multi-tape Turing machine using an f(n)-bit non-deterministic oracle, and let DTIME(g(n)) = NDTIME(0, g(n)). We show that if the all-pairs shortest paths problem (APSP) for directed graphs with N vertices and integer edge weights within a super-exponential range { -2Nk+o(1),.,2Nk+o(1)}, k≥1 does not admit a truly subc

Manifestation of panuveitis after intraocular surgery in a child with blau syndrome

Blau syndrome (BS) is a rare granulomatous disease with autosomal dominant inheritance. It is characterized by a triad of dermatitis, arthritis, and recurrent uveitis. This case presents the onset of panuveitis in BS after intraocular surgery. A 10-year-old boy presented to the outpatient clinic with retinal detachment in the left eye after 6 years following early-onset cataract surgery. Bilateral

Enhancing neuronal inhibition by cell and gene therapy as a novel treatment for Epilepsy

Epilepsy is a family of heterogeneous and multifactorial neurological disorders, unified by the occurrence of spontaneous recurrent seizures. Overall, it affects 50 million people worldwide of all ages and genders. Available treatments are only symptomatic and have severe side effects, while they also fail to provide adequate seizure control in a third of the patients. Therefore, a cure is yet to

Coordination during Cholera Outbreak Response : Critical Insights from Yemen

Within the humanitarian arena and since the introduction of the humanitarian reform process in 2005, the cluster approach was introduced to strengthen the cooperation and accountability between agencies working in the same field. Such an integrated approach is particularly needed and relevant in emergencies like cholera, especially in countries undergoing internal conflicts like Yemen. Several are

Let’s move beyond word battles and separatism: Strategies and concerns regarding Universal Design in Sweden

Purpose – Universal design (UD) is defined in the United Nations Convention on the Rights of Persons with Disabilities (UNCRPD) and adopted in Sweden as a guiding principle for the design of new products, facilities, services, etc. This study aims to contribute to knowledge about UD in practice – how it is conceived,experienced and discussed in Sweden, especially regarding education, working life

Four Decades of Air Temperature Data over Iran Reveal Linear and Nonlinear Warming

Spatiotemporal analysis of long-term changes in air temperature is of prime importance for climate change research and the development of effective mitigation and adaptation strategies. Although there is considerable research on air temperature change across the globe, most of it has been on linear trends and time series analysis of nonlinear trends has not received enough attention. Here, we anal

Exceptional fossil preservation: implications for palaeobiology and taphonomy

Although fossils are relatively common in some sedimentary deposits, the majority consists of fragmented or distorted skeletal hard parts (such as shell and bones). However, in rare cases, special burial and diagenetic conditions have allowed a greater portion of the original anatomy to be incorporated into the fossil record. This exceptional type of preservation is characterised by the retention

Preservation and Taphonomy of Fossil Insects from the Earliest Eocene of Denmark

Marine sediments of the lowermost Eocene Stolleklint Clay and Fur Formation of north-western Denmark have yielded abundant well-preserved insects. However, despite a long history of research, in-depth information pertaining to preservational modes and taphonomic pathways of these exceptional animal fossils remains scarce. In this paper, we use a combination of scanning electron microscopy coupled

The Many Faces of Performative Politics : Satires of Statesman Bernhard von Bülow in Wilhelmine Germany

While historical and contemporary thinkers have described politics as theater, this article moves beyond this representation of politics to understand how performance was central to politics around the turn of the twentieth century. It does so through an analysis of a large volume of hitherto unstudied caricatures of the German statesman Bernhard von Bülow. While historians usually describe satire

An Energy-Efficient Near-Memory Computing Architecture for CNN Inference at Cache Level

A non-von Neumann Near-Memory Computing architecture, optimized for CNN inference in edge computing, is integrated in the cache memory sub-system of a microcontroller unit. The NMC co-processor is evaluated using an 8-bit fixed-point quantized CNN model, and achieves an accuracy of 98% on the MNIST dataset. A full inference of the CNN model executed on the NMC processor, demonstrates an improvemen

Unboxing knowledge in collaboration between academia and society : A story about conceptions and epistemic uncertainty

Policymakers increasingly emphasize knowledge collaboration between academia and society as important means to generate innovations and solve complex issues. However, while recent literature on such collaboration suggests that knowledge needs to be integrated and generated across disciplines and sectors, there are surprisingly few studies that define what is meant by ‘knowledge’ or focus on the pr

Penile Intraepithelial Neoplasia and Penile Cancer. Risk Factors and Treatment.

AbstractPenile cancer and its precursor, penile intraepithelial neoplasia (PeIN), are rare malignancies. Data on risk factors, incidence, and treatment of PeIN is scarce. The prevalence of human papillomavirus (HPV) varies substantially between studies of penile cancer.The aims of this thesis were to explore the incidence, risk factors and treatment of PeIN; to analyse the prevalence of HPV and sk

Cross-borehole ERT : Sensitivity, model resolution, and field data quality

Sensitivity, resolution, and data quality are important parameters to consider when designing an ERT cross-borehole survey. We present an open-source algorithm for computing 2D and 3D sensitivity patterns of any borehole setup and use this to compare single-borehole and different cross-borehole electrode configurations, which both show complex patterns. To study the resolution capability of an ent

Three-dimensional time-lapse inversion of TEM data with application in an Icelandic geothermal site

The transient electromagnetic (TEM) method is widely used in resistivity mapping but rarely applied in monitoring experiments. In this study, we present an algorithm to invert time-lapse TEM data, with inversion of both synthetic data and field data. Three main novelties distinguish this new inversion algorithm: i) a multiple-mesh approach is used for the definition of model parameters and forward

Cross-borehole electrical monitoring in groundwater remediation projects : Understanding the flow path of remediation agents

In-situ remediation of contaminated groundwater often relies on the installation of a treatment zone degrading the pollution plume. In such projects, adequate delivery of remediation agents in the whole target volume is not trivial. Monitoring the spatial distribution of injected reagents is important for engineers and decision-makers, in order to determine the need of more careful injection in so

Att flytta förlorade naturvärden : Fungerar ekologisk kompensation för att ersätta naturvärden vid exploatering?

Ekologisk kompensation innebär att naturvärden som går förlorade på en plats tillförs på en annan plats. Tanken är att exploatering av mark- och vattenområden på så vis ska kunna ske samtidigt som värdefull natur bevaras. Fungerar då styrmedlet som avsett? Ekologisk kompensation kan verka vara en enkel lösning på en svår målkonflikt men en lärdom från andra länder är att måluppfyllelsen ofta är lå