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Transition to a circular plastic economy requires rethinking of the entire value chain from the raw materials and energy used for production, to material design, collection and recycling. Our focus has mainly been on polyesters as they span a wide scope of applications and properties ranging from durable to biodegradable. This presentation will highlight our work on designing and developing the bi

The paper is a keynote talk, introducing the problem with texts that are not finished - or maybe not even written at all but - but still haunts the imagination of the writer, specifically the creative writing student.

CONTEXT: Statin use is associated with increased risk of type 2 diabetes and mild hyperglycemia. The underlying mechanisms are not well studied and the effect of statin treatment on GLP-1 secretion or production are unknown.OBJECTIVE: To assess the effects of rosuvastatin on GLP-1 secretion and production.METHODS: We performed association studies in the Malmö Diet and Cancer study cardiovascular c

USP11 is a promising therapeutic target implicated in Alzheimer’s disease and various cancers; however, no specific inhibitors are currently available, with the only known inhibitor being mitoxantrone, which primarily targets topoisomerase II. To identify novel chemical starting points, we conducted high-throughput virtual screening using a USP11 homology model. Screening over 600,000 compounds yi

PARP15 is a mono-ADP-ribosyltransferase that targets an unknown set of proteins as well as RNA. Its evolutionary relationship with PARP14 suggests roles in antiviral defence; its localization to stress granules points to functions in the regulation of translation. Here we show that the transferase domain of PARP15 dimerizes in solution; the formation of dimers is a prerequisite for catalytic activ

Cell type annotation remains a critical bottleneck, with current methods often inaccurate and requiring extensive manual validation, particularly in disease contexts. While large language models (LLMs) show promise, they can be unreliable due to hallucinations. We developed CyteType, a multi-agent framework that generates competing hypotheses grounded in full expression data and study context, val

Accounting for the estimated number of undescribed species, Gelechioidea are thought to be among the most species-rich superfamilies of Lepidoptera, with 18,500 described species, including numerous pests of economically significant crops such as cotton, tomato and wheat. Family-level topology of the superfamily and the extent and the number of accepted families have received important revisions t

Ornamental horticultural plants in domestic gardens can constitute a substantial dispersal pool of potentially invasive species. Understanding garden owners' preferences when selecting plants, their awareness of dispersal pathways and how they manage their gardens is critical for effective invasive species control. This study used a survey to investigate Swedish garden owners' (n = 743) plant seleOrnamental horticultural plants in domestic gardens can constitute a substantial dispersal pool of potentially invasive species. Understanding garden owners' preferences when selecting plants, their awareness of dispersal pathways and how they manage their gardens is critical for effective invasive species control. This study used a survey to investigate Swedish garden owners' (n = 743) plant sele

The BCR::ABL1 tyrosine kinase inhibitors (TKIs) in CML represent a paradigm for molecularly targeted therapy. However, clinical outcomes - rate/depth of response, treatment-free remission (TFR), progression to blast crisis (BC) - and adverse events vary among patients. While additional somatic mutations have been invoked to explain varying clinical outcomes, we here propose a complementary perspec

Personality traits (e.g., the Big Five) shape human behavior, decision-making, and life outcomes. Evidence from various countries suggests that these traits are not randomly distributed but follow systematic regional patterns, fueling interest in their geographical variation. We analyze N = 22,225 geo-coded personality assessments, aggregated at regional levels. Using Hot Spot analysis (Getis-Ord

Previous versions of this paper were presented at seminars at BI Norwegian Business School and Toulouse School of Economics, and at the ANZESG 2024 meeting in Melbourne. The authors would like to thank all seminar and meeting participants, and in particular Anindya Banerjee (Editor), Jan Ditzen, Eric Gautier, Koen Jochmans, Bonsoo Koo, Adam Lee, Wooyong Lee, Thierry Magnac, Luca Margaritella, Simo

International research collaboration stands at a pivotal juncture, shaped by enduring structural inequalities between high-, middle-, and low-income countries and challenged by a trend of withdrawal from international collaboration. These asymmetries can create a misalignment between global scientific progress and the capacity to address pressing societal crises, which often disproportionately aff

Aim: Abiotic environmental conditions shape ecological and evolutionary processes, yet quantifying their influence on organisms remains challenging due to variation among metrics and their intercorrelations. This study evaluates the utility of temporal environmental predictability measures and assesses their explanatory power in phylogenetic comparative analyses. Innovation: We systematically comp

Ferulic acid (FA) is one of the most abundant hydroxycinnamic acids found in plant cell walls. Its dehydrodimers play an important role in maintaining the structural rigidity of the plant cell wall. Ferulic acid esterases (FAEs) act as debranching enzymes, cleaving the ester bond between FA and the substituted carbohydrate moieties in FA-containing polysaccharides in the plant cell wall. This enzy

We present a method for obtaining an initial-state parton shower model where the (backward) evolution fully consistent with the (forward) evolution of the collinear parton density used. As a proof-of-concept we use parton densities obtained with the parton branching (PB) approach, and modify the default initial-state shower in Pythia8 with this method to be consistent with them. PB is ideally suit

Background/objectives: Being overweight increases the predisposition to obesity and type 2 diabetes (T2D), which significantly elevate stroke risk and the likelihood of severe post-stroke disability. Dietary nitrate (NO3−) supplementation can mitigate obesity and metabolic impairments, making it a promising approach to halt overweight people from developing overt obesity/T2D, thereby potentially a