BACKGROUND AND PURPOSE: In patients around retirement age controversy exists as to whether to treat displaced femoral neck fracture (dFNF) with internal fixation (IF) or arthroplasty. An arthroplasty in this age group may need revision due to a long expected remaining lifetime. IF carries a higher risk of early failure but a maintained native hip if healing occurs. We aimed to determine the cumula

According to the Intuition of Neutrality, there is a range of well-being levels such that adding people with lives at these levels doesn’t make the world either better or worse. As lives in the neutral range can be good for those who live them, this intuition is in conflict with one of the main tenets of welfarism; it creates a disparity between what is good for a person and what is impersonally g

You can save either David or Peter and Mary. Is there a compelling reason for saving the greater number? Taurek (1977) (in)famously denied it. In providing such reason one might attempt to establish that it is better if more people survive rather than fewer. This would settle the issue for consequentialists, but even non-consequentialists might find it relevant to the question at hand. The standar

AIM: We suggest the top ten tips that any clinician working in a pediatric emergency department should always keep in mind.METHODS: A literature review was conducted using, as a starting point, the previously published Ten Commandments for Emergency Medicine, Pediatric Emergency Medicine, and Perinatal Medicine.RESULTS AND CONCLUSION: A standard curriculum for pediatric emergency physicians is lac

This report aims to identify both barriers that hinder energy-efficient renovation of buildings and drivers enabling the implementation of energy and cost-effective renovation of buildings and energy supply systems at the district level.Fifteen success stories regarding barriers and drivers were analysed in the first step. These success stories consisted of projects from seven European countries (

BACKGROUND: Metabolic alterations contribute to disease onset and prognosis of Huntington's disease (HD). Weight loss in the R6/2 mouse model of HD is a consistent feature, with onset in mid-to-late stage of disease.OBJECTIVE: In the present study, we aimed to investigate molecular and functional changes in white adipose tissue (WAT) that occur at weight loss in R6/2 mice. We further elaborated on

This paper presents new estimates of the material livings standards among the rural population in southern Sweden from the 1680’s up to 1865. Utilizing a newly constructed database of circa 1800 probate inventories from the benchmark periods 1680-1720, 1780-85, and 1860-65, we analyse the development of consumption patterns for rural households. Wefind that that all rural households, no matter the

Integration of fiber modification step with a modern pulp mill is a resource efficient way to produce functional fibers. Motivated by the need to integrate polymer adsorption with the current pulping system, anion-specific effects in carboxymethylcellulose (CMC) adsorption have been studied. The QCM-D adsorption experiments revealed that CMC adsorption to the cellulose model surface is prone to an

This paper studies the nexus between income and wealth inequality, and the ecological footprint in the United States and France from 1962 to 2021. Based on theoretical considerations, we allow the relationship to vary over time. We find some support for income inequality affecting the ecological footprint in the United States and that the relationship has changed over time. We find no such result This paper studies the nexus between income and wealth inequality, and the ecological footprint in the United States and France from 1962 to 2021. Based on theoretical considerations, we allow the relationship to vary over time. We find some support for income inequality affecting the ecological footprint in the United States and that the relationship has changed over time. We find no such result

Optimising waste management is one of the key areas in sustainable development to protect public health and the environment. However, most countries are yet to achieve sustainable waste management due to increasing waste generation, limited landfill space, resource depletion, cost of recycling, public buy-in, etc. These challenges have resulted in poor waste management and environmental pollution

The understanding of small cell lung cancer (SCLC) biology has increased dramatically in recent years, but the processes that allow SCLC to progress rapidly remain poorly understood. Here, we advocate the integration of rapid autopsies and preclinical models into SCLC research as a comprehensive strategy with the potential to revolutionize current treatment paradigms.

In this study we use finite rate chemistry Large Eddy Simulation (LES) to examine flow, injection, mixing, self-ignition and turbulent combustion in a dual-mode ramjet combustor with a cavity flameholder. The target case is the dual-mode ramjet combustor studied experimentally by Micka & Driscoll in a series of publications under different operating conditions characterized by varying air stag

In adaptive immune receptor repertoire analysis, determining the germline variable (V) allele associated with each T- and B-cell receptor sequence is a crucial step. This process is highly impacted by allele annotations. Aligning sequences, assigning them to specific germline alleles, and inferring individual genotypes are challenging when the repertoire is highly mutated, or sequence reads do not

This study explores the challenges and possibilities of using ammonia (NH3) as a carbon-free fuel for marine propulsion in a Wärtsilä ammonia/diesel dual-fuel engine using a reactivity-controlled compression ignition (RCCI) concept. The main issues in ammonia RCCI engines are high ammonia slip and high emissions of nitrogen oxides and nitrous oxide. A joint experimental and computational investiga

BACKGROUND: Breast cancer is, despite screening, not always detected early enough and is together with other tumor types known to shed genetic information in circulation. Unlike single-copy nuclear DNA, mitochondrial DNA (mtDNA) copies range from 100s to 10,000s per cell, thus providing a potentially alternative to identify potential missing cancer information in circulation at an early stage.METH

Microglia have an innate immunity memory (IIM) with divergent functions in different animal models of neurodegenerative diseases, including Alzheimer's disease (AD). AD is characterized by chronic neuroinflammation, neurodegeneration, tau tangles and β-amyloid (Aβ) deposition. Systemic inflammation has been implicated in contributing to the progression of AD. Multiple reports have demonstrated uni

Objective. To investigate the occurrence of cardiovascular events (CVEs) in a large cohort of patients with antineutrophil cytoplasmic antibody (ANCA)-Associated vasculitis (AAV) across the European Union, China, Turkey, Russia, the United Kingdom, and the USA. Methods. Patients with a definite diagnosis of AAV who were followed for ? 3 months and had sufficient documentation were included. Data o