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ObjectivesLack of trust and transparency is stressed as a challenge for clinical implementation of Artificial Intelligence (AI). In breast cancer screening, AI-supported reading shows promising results but more research is needed on how medical experts, that are facing the integration of AI into their work, reason about trust and information needs. From a sociotechnical information practice perspe
It is assumed that nursing is performed on a scientific knowledge-based approach toward patients that considers the wellbeing of the whole person. The meaning and understanding are essentialwhen conceptualizing the idea of caring for the whole person and how this is applied by nurses inhealthcare. However, the meaning and understanding of holism varies widely according to research. The aim of this
It is generally recommended to refrain from taking rectal biopsies in radioproctopathy. Herein we describe the clinical characteristics of urorectal fistulas after such biopsies in five patients. Conservative treatment is rarely successful. Diagnostic difficulties and comorbidities limiting the possibilities for radical surgical treatment options (i e pelvic exenteration) for urorectal fistulas ar
Increasing recognition of germline DDX41 variants in patients with hematological malignancies prompted us to provide DDX41-specific recommendations for diagnosis, surveillance, and treatment. Causative germline variants in the DDX41 predispose to the development of myeloid neoplasms (MNs), especially myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Almost 3%–5% of all patients with
Sub-Saharan Africa has fewer medical workers per capita than any region of the world, and that shortage has been highlighted consistently as a critical constraint to improving health outcomes in the region. This paper draws on newly available, systematic, comparable data from 10 countries in the region to explore the dimensions of this shortage. We find wide variation in human resources performanc
The influence of different preparation methods on the physicochemical properties of amorphous solid forms have gained considerable attention, especially with recent publications on pharmaceutical polyamorphism. In the present study, we have investigated the possible occurrence of polyamorphism in the drug celecoxib (CEL) by investigating the thermal behavior, morphology, structure, molecular mobil
Aims Short-term ambulatory electrocardiogram (ECG) monitoring is often used to assess premature atrial complex (PAC) and premature ventricular complex (PVC) frequency, but the diagnostic reliability is unknown. The objective of this study was to study the day-to-day variability of PAC and PVC frequency. Methods We used 14-day full-disclosure mobile cardiac telemetry recordings without atrial fibri
Generalist plant-feeding insects are characterised by a broad host repertoire that can comprise several families or even different orders of plants. The genetic and physiological mechanisms underlying the use of such a wide host range are still not fully understood. Earlier studies indicate that the consumption of different host plants is associated with host-specific gene expression profiles. It
In this short Briefing Paper we consider a number of issues in response to the Draft Tasmanian Renewable Hydrogen Action Plan, published November 2019. Our research team has been exploring the potential role renewable hydrogen could play in bolstering Australia’s and Tasmania’s energy autonomy and energy security. We are a social science research team, comprising expertise in law, industrial econo
Background: The impulsive choice is characterized by the preference for a small immediate reward over a bigger delayed one. The mechanisms underlying impulsive choices are linked to the activity in the Nucleus Accumbens (NAc), the orbitofrontal cortex (OFC), and the dorsolateral striatum (DLS). While the study of functional connectivity between brain areas has been key to understanding a variety o
Changes in the extracellular matrix of pulmonary arteries (PAs) are a key aspect of vascular remodeling in pulmonary hypertension (PH). Yet, our understanding of the alterations affecting the proteoglycan (PG) family remains limited. We sought to investigate the expression and spatial distribution of major vascular PGs in PAs from healthy individuals and various PH groups (chronic obstructive pulm
In the framework of the RECCAP2 initiative, we present the greenhouse gas (GHG) and carbon (C) budget of Europe. For the decade of the 2010s, we present a bottom-up (BU) estimate of GHG net-emissions of 3.9 Pg CO2-eq. yr−1 (using a global warming potential on a 100 years horizon), which are largely dominated by fossil fuel emissions. In this decade, terrestrial ecosystems acted as a net GHG sink o
This report is a synthesis analysis to a project that has been carried out within the collaborative research program Renewable transportation fuels and systems (Förnybara drivmedel och system), Project no. 40771-1, Environmental and Socio-Economic Benefits from Swedish Biofuel Produc- tion. The project has been financed by the Swedish Energy Agency and f3 – Swedish Knowledge Centre for Renewable T
Background: Identifying factors associated with vaccine uptake among health care workers (HCWs) remains crucial to generating evidence aimed at guiding national COVID-19 vaccination and future infectious disease outbreak strategies. This study aimed to elucidate these factors, focusing on the interplay between socio-demographic, health, knowledge, beliefs and attitudinal indicators. Methods: This
Purpose:To study the incidence, predictive factors, etiology, and visual consequences of postoperative endophthalmitis (PE) in relation to 3 intracameral (IC) antibiotic regimes.Setting:Swedish National Cataract Register entries from 2011 through 2017.Design:Observational retrospective study.Methods:PE incidence, influencing factors, bacteriology, and visual outcome were analyzed regarding the 3 m
We study pair correlation functions for planar Coulomb systems in the pushed phase, near a ring-shaped impenetrable wall. We assume coupling constant Γ=2 and that the number n of particles is large. We find that the correlation functions decay slowly along the edges of the wall, in a narrow interface stretching a distance of order 1/n from the hard edge. At distances much larger than 1/n, the effe
Histidine is a key amino-acid residue in proteins with unique properties engendered by its imidazole side chain that can exist in three different states: two different neutral tautomeric forms and a protonated, positively charged one with a pKa value close to physiological pH. Commonly, two or all three states coexist and interchange rapidly, enabling histidine to act as both donor and acceptor of
It is generally known that, unlike structured proteins, intrinsically disordered proteins, IDPs, exhibit various structures and conformers, the so-called conformational ensemble, CoE. This study aims to better understand the conformers that make up the IDP ensemble by decomposing the CoE into groups separated by their radius of gyration, Rg. A common approach to studying CoE for IDPs is to use low
Aims The European Unified Registries On Heart Care Evaluation and Randomized Trials (EuroHeart) aims to improve the quality of care and clinical outcomes for patients with cardiovascular disease. The collaboration of acute coronary syndrome/percutaneous coronary intervention (ACS/PCI) registries is operational in seven vanguard European Society of Cardiology member countries. Methods and Adults ad
