Cirka 1000 barn föds med hjärtfel i Sverige varje år och idag överlever de flesta och uppnår vuxen ålder. Det finns uppskattningsvis 2.3 miljoner vuxna med medfött hjärtfel i Europa idag, en siffra som förväntas öka. Samtidigt har prevalensen av patienter med komplexa medfödda hjärtfel också ökat de senaste 10 åren. Det finns således ett behov av att öka kunskapen om patofysiologin vid dessa sjukdAround 1000 children are born with a heart disease in Sweden every year and today most of these children survive and reach adult age. There are around 2.3 million grownups with congenital heart disease in Europe today, a number that is expected to continue to increase. Further, the prevalence of patients with complex malformations has been growing significantly the last 10 years. There is thus a n

Aims: The nuclear proliferation marker Ki67 assayed by immunohistochemistry has multiple potential uses in breast cancer, but an unacceptable level of interlaboratory variability has hampered its clinical utility. The International Ki67 in Breast Cancer Working Group has undertaken a systematic programme to determine whether Ki67 measurement can be analytically validated and standardised among lab

This paper aims to answer a simple and elemental question: how do we qualify and quantify thermal comfort in highly glazed spaces with diverse occupants’ use and expectation? And, how can designers achieve enhanced occupant experience with passive measures, minimizing the use of HVAC systems in such spaces? In this study variables, such as air and radiant temperatures, air velocity, relative humid

Stars near the Sun oscillate both horizontally and vertically. In a previous paper by Binney it was assumed that the coupling between these motions can be modelled by determining the horizontal motion without reference to the vertical motion, and recovering the coupling between the motions by assuming that the vertical action is adiabatically conserved as the star oscillates horizontally. Here, we

The recently discovered Kepler circumbinary systems and the circumbinary polar-ring debris disc in the 99 Herculis system call for the study of circumbinary orbits. As an approximation, it is advisable to investigate the problem with the assumption that the outer body is massless. In such a scheme, we briefly summarize the main characteristics of the evolution of the orbits and give the general so

The solar neighbourhood contains disc stars that have recently crossed spiral arms in the Galaxy. We propose that boundaries in local velocity distributions separate stars that have recently crossed and been more strongly perturbed by a particular arm from those that haven't. Ridges in the stellar velocity distributions constructed from the second Gaia data release trace orbits that could have tou

The gravitational interaction between two objects on similar orbits can effect noticeable changes in the orbital evolution even if the ratio of their masses to that of the central body is vanishingly small. Christou (Icarus 174:215–229, 2005) observed an occasional resonant lock in the differential node ΔΩ between two members in the Himalia irregular satellite group of Jupiter in the N-body simula

In extending the analysis of the four secular resonances between close orbits in Li and Christou (Celest Mech Dyn Astron 125:133–160, 2016) (Paper I), we generalise the semianalytical model so that it applies to both prograde and retrograde orbits with a one-to-one map between the resonances in the two regimes. We propose the general form of the critical angle to be a linear combination of apsidal

We explore the connections between stellar age, chemistry, and kinematics across a Galactocentric distance of 7.5 < R(kpc) < 9.0, using a sample of ~12 000 intermediate-mass (FGK) turn-offstars observed with the RAdial Velocity Experiment (RAVE) survey. The kinematics of this sample are determined using radial velocity measurements from RAVE, and parallax and proper motion measurements from the T

Among the irregular satellites orbiting Jupiter, the Himalia family is characterized by a high velocity dispersion dv of several hundred m s-1 among its members, inconsistent with a collisional origin. Efforts to account for this through internecine gravitational interactions do not readily reproduce this feature. Here, we revisit the problem in the context of recent cosmogonical models, where the

More than 50 irregular satellites revolve around Jupiter and more than 30 around Saturn. There, at least three collisional families were identified. Among these, the Himalia family of prograde irregular moons at Jupiter is characterised by a velocity dispersion of several hundred m/s, inconsistent with a collisional origin (Nesvorný et al., 2003). Here we investigate whether the dispersion could s

We characterize the selection function of RAdial Velocity Experiment (RAVE) using 2 Micron All Sky Survey (2MASS) as our underlying population, which we assume represents all stars that could have potentially been observed.We evaluate the completeness fraction as a function of position, magnitude and colour in two ways: first, on a field-by-field basis, and second, in equal-size areas on the sky.

Året är 2053 och den svenska regeringen har just invigt museet FOSSIL och dess första utställning ’Carbon Ruins’. År 2045 uppnådde Sverige nettonollutsläpp av växthusgaser, och blev därmed det första landet i världen att lämna den fossila tidsåldern (1849 - 2049). Två hundra år som förde med sig en otrolig välståndsökning, men också oljerelaterade konflikter och en klimatkatastrof som allvarligt hIt is 2053. The Swedish government has just opened its landmark museum FOSSIL with its first exhibition Carbon Ruins. The exhibition and its grand opening is a celebration of the fact that global net-zero emissions of carbon dioxide were reached in 2050. Sweden, in line with its 2017 targets, reached net-zero emissions of greenhouse gases already in 2045, being the first country in the world to st

Context. Aims. The goal of this paper is to demonstrate the outstanding quality of the second data release of the Gaia mission and its power for constraining many different aspects of the dynamics of the satellites of the Milky Way. We focus here on determining the proper motions of 75 Galactic globular clusters, nine dwarf spheroidal galaxies, one ultra-faint system, and the Large and Small Mage

Context. The ESA Gaia mission provides a unique time-domain survey for more than 1.6 billion sources with G ≲ 21 mag. Aims. We showcase stellar variability in the Galactic colour-absolute magnitude diagram (CaMD). We focus on pulsating, eruptive, and cataclysmic variables, as well as on stars that exhibit variability that is due to rotation and eclipses. Methods. We describe the locations of var