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Osteoarthritis (OA) is the most common joint disease, where articular cartilage degradation is often accompanied with sclerosis of the subchondral bone. However, the association between OA and tissue mineralization at the nanostructural level is currently not understood. In particular, it is technically challenging to study calcified cartilage, where relevant but poorly understood pathological pro

The Einstein Telescope (ET), a wide-band, future third generation gravitational wave detector, is expected to have detection rates of ∼105 − 106 binary black hole (BBH) detections and ∼7 × 104 binary neutron star (BNS) detections in one year. The coalescence of compact binaries with a total mass of 20–100 M⊙, typical of BH-BH or BH-NS binaries, will be visible up to redshift z ≈ 20 and even higher

Additive manufacturing (AM) was introduced the 1980's for rapid prototyping (RP) purposes but now AM provides complementary techniques to conventional manufacturing processes and offers advantages when components can be exacting, impossible, and too costly to be produced by conventional methods due to complex structures and geometric configurations, which require tailored designs. They are also of

In this study we introduce a novel extension of an existing Lagrangian particle dispersion model for application over urban areas by explicitly taking into account the urban canopy layer. As commonly done, the original model uses the zero-plane displacement as a lower boundary condition, while the extension reaches to the ground. To achieve this, spatially-averaged parametrizations of flow and tur

This paper introduces a process model of how academics learn to bridge different cognitive scripts, thereby learning to collaborate with non-academic managers in the context of multidisciplinary academic spinoff (ASO) teams. Whereas prior research has taken a static perspective, showing that cooperation in ASO teams is challenging due to differences in cognitive scripts, we take a dynamic perspect

Purpose: To determine the effect of glaucomatous visual field (VF) damage close to the point of fixation, called threat-to-fixation (TTF), on vision-related quality of life (VRQoL) in open-angle glaucoma. Methods: A total of 239 patients from the Glaucoma Intensive Treatment Study (GITS) were included in this analysis. The second VF of patients with newly diagnosed primarily early glaucoma was eva

Connectivity between and within places is one of the cornerstones of geography. However, the data and methodologies used to capture connectivity are limited due to the difficulty in gathering and analysing detailed observations in time and space. Mobile phone data potentially offer a rich and unprecedented source of data, which is exhaustive in time and space following movements and communication

BACKGROUND: Established anatomical classifications of infrapopliteal arterial lesion severity are based on assessment of only one target artery, not including all infrapopliteal arteries although multivessel revascularization is common.PURPOSE: To investigate the reproducibility of one of these classifications and a new aggregated score.MATERIAL AND METHODS: A total of 68 patients undergoing endov

Is it possible to enjoy both economic growth and environmental sustainability? This question is a matter of fierce political debate between green growth and post-growth advocates. Over the past decade, green growth clearly dominated policy making with policy agendas at the United Nations, European Union, and in numerous countries building on the assumption that decoupling environmental pressures f

Uncharacterized side activities of enzymes can have significant negative effects on reaction products and yields. Hence, their identification and characterization is crucial for the development of successful reaction systems. Here, we report the presence of feruloyl esterase activity in CtXyn5A from Acetivibrio thermocellus besides its well-known arabinoxylanase activity for the first time. Both r

BackgroundLow concentrations of serum selenium (Se) and its main transporter selenoprotein P (SELENOP) are associated with a poor prognosis following breast cancer diagnosis. Recently, natural autoantibodies (aAb) with antagonistic properties to SELENOP uptake have been identified in healthy subjects, and in patients with thyroid disease. Given the potential transport disrupting properties, we hyp

Zinc has been suggested to play a role in breast cancer progression; however, no previous study on zinc levels and the potential effect on breast cancer survival has been conducted. This study investigates recurrence-free survival (RFS), breast cancer-specific survival (BCSS) and overall survival (OS) in relation to zinc levels, in serum and diet, overall and stratified for phosphorus and selenium

As a complex hydrological problem, rainfall-runoff (RR) modeling is of importance in runoff studies, water supply, irrigation issues, and environmental management. Among the variety of approaches for RR modeling, conceptual approaches use physical concepts and are appropriate methods for representation of the physics of the problem while may fail in competition with their advanced alternatives. Co